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Research ArticleClinical Studies

Correlation of Pre- and Post-radio-chemotherapy MRI Texture Features With Tumor Response in Rectal Cancer

FABIOLA PAIAR, MICHELA GABELLONI, FRANCESCO PASQUALETTI, PAOLA COCUZZA, SABRINA MONTRONE, CHIARA ARENA, LORENZO FAGGIONI, ZENO FALASCHI, LORENZO DEL SECCO, ANGEL ALBERICH-BAYARRI, LUIS MARTI BONMATI and EMANUELE NERI
Anticancer Research February 2023, 43 (2) 781-788; DOI: https://doi.org/10.21873/anticanres.16218
FABIOLA PAIAR
1Radiation Oncology, Department of Translational Research, University of Pisa, Pisa, Italy;
2Radiation Oncology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy;
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MICHELA GABELLONI
3Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy;
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FRANCESCO PASQUALETTI
2Radiation Oncology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy;
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  • For correspondence: f.pasqualetti@ao-pisa.toscana.it francesco.pasqualetti@oncology.ox.ac.uk
PAOLA COCUZZA
4Radiation Oncology, Area Vasta NordOvest, Lucca, Italy;
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SABRINA MONTRONE
2Radiation Oncology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy;
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CHIARA ARENA
3Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy;
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LORENZO FAGGIONI
3Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy;
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ZENO FALASCHI
3Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy;
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LORENZO DEL SECCO
3Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy;
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ANGEL ALBERICH-BAYARRI
5QUIBIM SL, Quantitative Imaging Biomarkers in Medicine, GIBI230, Biomedical Imaging Research Group, La Fe Health Research Institute, Valencia, Spain;
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LUIS MARTI BONMATI
6Department of Radiology, Quirón Hospital, Valencia, Spain;
7Biomedical Imaging Research Group (GIBI2^30), Hospital Universitari i Politècnic La Fe, Valencia, Spain
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EMANUELE NERI
3Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy;
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Abstract

Background/Aim: The present study aimed to investigate radiomics features derived from magnetic resonance imaging (MRI) in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (CRT). Patients and Methods: We retrospectively evaluated data of 53 patients (32 males, 21 females) with T3/T4 or N+ rectal cancer who underwent MRI before and after CRT. Twenty-seven texture radiomics features were extracted from regions of interest, delimiting the tumor on T2-weighted images. Results: All 27 radiomics features extracted before CRT showed a statistically significant association with the tumor regression grade (TRG) (p<0.05), whereas, after CRT, only the Cluster Prominence value was the only variable to predict TRG (p=0.037, r=0.291). Conclusion: All 27 features extracted before CRT were able to predict response to CRT and Cluster Prominence continued to be statistically significant even after CRT. The impact of radiomics features derived from MRI could be further investigated in patients with locally advanced rectal cancer.

Key Words:
  • Locally advanced rectal cancer
  • radiomics
  • magnetic resonance imaging
  • chemo-radiotherapy
  • Received December 15, 2022.
  • Revision received December 21, 2022.
  • Accepted December 23, 2022.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 43 (2)
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Correlation of Pre- and Post-radio-chemotherapy MRI Texture Features With Tumor Response in Rectal Cancer
FABIOLA PAIAR, MICHELA GABELLONI, FRANCESCO PASQUALETTI, PAOLA COCUZZA, SABRINA MONTRONE, CHIARA ARENA, LORENZO FAGGIONI, ZENO FALASCHI, LORENZO DEL SECCO, ANGEL ALBERICH-BAYARRI, LUIS MARTI BONMATI, EMANUELE NERI
Anticancer Research Feb 2023, 43 (2) 781-788; DOI: 10.21873/anticanres.16218

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Correlation of Pre- and Post-radio-chemotherapy MRI Texture Features With Tumor Response in Rectal Cancer
FABIOLA PAIAR, MICHELA GABELLONI, FRANCESCO PASQUALETTI, PAOLA COCUZZA, SABRINA MONTRONE, CHIARA ARENA, LORENZO FAGGIONI, ZENO FALASCHI, LORENZO DEL SECCO, ANGEL ALBERICH-BAYARRI, LUIS MARTI BONMATI, EMANUELE NERI
Anticancer Research Feb 2023, 43 (2) 781-788; DOI: 10.21873/anticanres.16218
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Keywords

  • Locally advanced rectal cancer
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