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Research ArticleClinical Studies

Analysis of an Unselected Patient Cohort With Advanced Colorectal Carcinoma from a Maximum Care Center

XIN-WEN ZHANG, JUTTA MOHR, NIELS HALAMA and RONALD KOSCHNY
Anticancer Research December 2023, 43 (12) 5589-5596; DOI: https://doi.org/10.21873/anticanres.16761
XIN-WEN ZHANG
1Medical Oncology and Internal Medicine VI, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, INF 460, Heidelberg, Germany;
2Translational Immunotherapy (D240), German Cancer Research Center (DKFZ), INF 280, Heidelberg, Germany;
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JUTTA MOHR
3Department of Gastroenterology, Hepatology, Infectious Diseases and Intoxication, Heidelberg University Hospital, INF 410, Heidelberg, Germany;
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NIELS HALAMA
1Medical Oncology and Internal Medicine VI, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, INF 460, Heidelberg, Germany;
2Translational Immunotherapy (D240), German Cancer Research Center (DKFZ), INF 280, Heidelberg, Germany;
4BioQuant, Faculty of Biosciences, Heidelberg University, INF 267, Heidelberg, Germany
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  • For correspondence: niels.halama@nct-heidelberg.de
RONALD KOSCHNY
3Department of Gastroenterology, Hepatology, Infectious Diseases and Intoxication, Heidelberg University Hospital, INF 410, Heidelberg, Germany;
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  • For correspondence: ronald.koschny@med.uni-heidelberg.de
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Abstract

Background/Aim: Systemic treatment for metastatic colorectal cancer (CRC) includes chemotherapy in combination with a targeted antibody. Novel targeted therapies and immunotherapies are introduced for specific molecular subgroups. Prognostic relevant determinants are still under investigation. Patients and Methods: Systemic therapies of an unselected patient cohort with metastatic CRC were retrospectively analyzed. Treatment outcome was evaluated according to time-to-next-treatment (TTNT) and frequency of conversion surgery and compared between subgroups stratified by primary tumor side, molecular profile, sex and age, and metastases sites. Results: More than 50% of patients with locally advanced or metastatic CRC underwent secondary resection after first-line systemic therapy. Rectum carcinoma had the best prognosis under anti-EGFR-antibody treatment. Female patients had a worse prognosis than male patients in late disease stage. Young patients demonstrated poor response to systemic therapy, but a high rate of conversion surgeries. Conversely, elderly patients benefited from systemic therapy but underwent surgery less frequently. Liver and lung metastases had a worse prognosis than other metastases sites, whereas lung metastases were more likely to be resected than liver metastases in early disease stage. Conclusion: Patient age, sex, primary tumor localization, and metastatic sites are prognostic factors that could guide future treatment decisions for the therapy of metastatic CRC.

Key Words:
  • Colorectal cancer
  • time-to-next-treatment
  • chemotherapy
  • secondary surgery
  • tumor sidedness
  • metastases
  • colorectal liver metastases
  • Received October 9, 2023.
  • Revision received November 10, 2023.
  • Accepted November 14, 2023.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 43 (12)
Anticancer Research
Vol. 43, Issue 12
December 2023
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Analysis of an Unselected Patient Cohort With Advanced Colorectal Carcinoma from a Maximum Care Center
XIN-WEN ZHANG, JUTTA MOHR, NIELS HALAMA, RONALD KOSCHNY
Anticancer Research Dec 2023, 43 (12) 5589-5596; DOI: 10.21873/anticanres.16761

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Analysis of an Unselected Patient Cohort With Advanced Colorectal Carcinoma from a Maximum Care Center
XIN-WEN ZHANG, JUTTA MOHR, NIELS HALAMA, RONALD KOSCHNY
Anticancer Research Dec 2023, 43 (12) 5589-5596; DOI: 10.21873/anticanres.16761
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Keywords

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