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Research ArticleExperimental Studies
Open Access

Therapeutic Efficacy of Prodrug Activator Gene Therapy Using Retroviral Replicating Vectors for Human Ovarian Cancer

LISA ISODA, EMIKO SONODA-FUKUDA, HIROAKI FUJINO, TORU TAKARADA, KOSEI HASEGAWA, NORIYUKI KASAHARA and SHUJI KUBO
Anticancer Research December 2023, 43 (12) 5311-5317; DOI: https://doi.org/10.21873/anticanres.16734
LISA ISODA
1Laboratory of Molecular and Genetic Therapeutics, Institute of Advanced Medical Science, Hyogo Medical University, Nishinomiya, Japan;
2Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Japan;
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EMIKO SONODA-FUKUDA
1Laboratory of Molecular and Genetic Therapeutics, Institute of Advanced Medical Science, Hyogo Medical University, Nishinomiya, Japan;
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HIROAKI FUJINO
1Laboratory of Molecular and Genetic Therapeutics, Institute of Advanced Medical Science, Hyogo Medical University, Nishinomiya, Japan;
2Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Japan;
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TORU TAKARADA
1Laboratory of Molecular and Genetic Therapeutics, Institute of Advanced Medical Science, Hyogo Medical University, Nishinomiya, Japan;
3Laboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University, Kobe, Japan;
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KOSEI HASEGAWA
4Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka, Japan;
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NORIYUKI KASAHARA
5Departments of Neurological Surgery and Radiation Oncology, University of California, San Francisco, CA, U.S.A.
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SHUJI KUBO
1Laboratory of Molecular and Genetic Therapeutics, Institute of Advanced Medical Science, Hyogo Medical University, Nishinomiya, Japan;
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  • For correspondence: s-kubo{at}hyo-med.ac.jp
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Article Information

vol. 43 no. 12 5311-5317
DOI 
https://doi.org/10.21873/anticanres.16734
PMID 
38030176

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received October 17, 2023
  • Revision received November 13, 2023
  • Accepted November 14, 2023
  • Published online November 29, 2023.

Copyright & License 
Copyright © 2023 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. LISA ISODA1,2,
  2. EMIKO SONODA-FUKUDA1,
  3. HIROAKI FUJINO1,2,
  4. TORU TAKARADA1,3,
  5. KOSEI HASEGAWA4,
  6. NORIYUKI KASAHARA5 and
  7. SHUJI KUBO1⇑
  1. 1Laboratory of Molecular and Genetic Therapeutics, Institute of Advanced Medical Science, Hyogo Medical University, Nishinomiya, Japan;
  2. 2Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Japan;
  3. 3Laboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University, Kobe, Japan;
  4. 4Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka, Japan;
  5. 5Departments of Neurological Surgery and Radiation Oncology, University of California, San Francisco, CA, U.S.A.
  1. Correspondence to: Shuji Kubo, Laboratory of Molecular and Genetic Therapeutics, Institute for Advanced Medical Sciences, Hyogo Medical University,1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. Tel: +81 798456844, e-mail: s-kubo{at}hyo-med.ac.jp
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Anticancer Research: 43 (12)
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Therapeutic Efficacy of Prodrug Activator Gene Therapy Using Retroviral Replicating Vectors for Human Ovarian Cancer
LISA ISODA, EMIKO SONODA-FUKUDA, HIROAKI FUJINO, TORU TAKARADA, KOSEI HASEGAWA, NORIYUKI KASAHARA, SHUJI KUBO
Anticancer Research Dec 2023, 43 (12) 5311-5317; DOI: 10.21873/anticanres.16734

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Therapeutic Efficacy of Prodrug Activator Gene Therapy Using Retroviral Replicating Vectors for Human Ovarian Cancer
LISA ISODA, EMIKO SONODA-FUKUDA, HIROAKI FUJINO, TORU TAKARADA, KOSEI HASEGAWA, NORIYUKI KASAHARA, SHUJI KUBO
Anticancer Research Dec 2023, 43 (12) 5311-5317; DOI: 10.21873/anticanres.16734
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Keywords

  • ovarian cancer
  • retroviral replicating vectors
  • prodrug activator gene therapy
  • cancer virotherapy
  • amphotropic murine leukemia virus
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