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Research ArticleClinical Studies

Intraoperative Blood Loss Impacts Recurrence and Survival in Patients With Locally Advanced Esophageal Cancer

HAYATO WATANABE, KAZUKI KANO, ITARU HASHIMOTO, MIE TANABE, SHIZUNE ONUMA, JUNYA MORITA, SHINSUKE NAGASAWA, KYOHEI KANEMATSU, TORU AOYAMA, TAKANOBU YAMADA, TAKASHI OGATA, YASUSHI RINO, AYA SAITO and TAKASHI OSHIMA
Anticancer Research November 2023, 43 (11) 5173-5179; DOI: https://doi.org/10.21873/anticanres.16718
HAYATO WATANABE
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
2Department of Surgery, Yokohama City University, Yokohama, Japan
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KAZUKI KANO
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
2Department of Surgery, Yokohama City University, Yokohama, Japan
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ITARU HASHIMOTO
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
2Department of Surgery, Yokohama City University, Yokohama, Japan
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MIE TANABE
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
2Department of Surgery, Yokohama City University, Yokohama, Japan
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SHIZUNE ONUMA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
2Department of Surgery, Yokohama City University, Yokohama, Japan
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JUNYA MORITA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
2Department of Surgery, Yokohama City University, Yokohama, Japan
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SHINSUKE NAGASAWA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
2Department of Surgery, Yokohama City University, Yokohama, Japan
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KYOHEI KANEMATSU
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
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TORU AOYAMA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
2Department of Surgery, Yokohama City University, Yokohama, Japan
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TAKANOBU YAMADA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
2Department of Surgery, Yokohama City University, Yokohama, Japan
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TAKASHI OGATA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
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YASUSHI RINO
2Department of Surgery, Yokohama City University, Yokohama, Japan
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AYA SAITO
2Department of Surgery, Yokohama City University, Yokohama, Japan
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TAKASHI OSHIMA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
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  • For correspondence: oshimat{at}kcch.jp
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  • Figure 1.
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    Figure 1.

    Flow chart of patient selection. In total, 220 patients diagnosed with clinical stage II or III esophageal squamous cell carcinoma and underwent curative esophagectomy after neoadjuvant chemotherapy were eligible for inclusion. Of these, 22 patients were excluded: 13 patients who received triple chemotherapy in a clinical trial, eight patients who underwent non-curative resection, and one patient whose postoperative pathological diagnosis included neuroendocrine carcinoma. Finally, a total of 198 patients were included in this study. ESCC: Esophageal squamous cell carcinoma.

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    Figure 2.

    Recurrence-free survival (RFS) in the high and low IBL groups. The RFS in the high intraoperative blood loss (IBL) group was significantly poorer than that in the low IBL group (p=0.002, log-rank test).

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    Figure 3.

    Overall survival (OS) in the high and low intraoperative blood loss (IBL) groups. The OS in the high IBL group was significantly poorer than that in the low IBL group (p=0.010, log-rank test).

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Anticancer Research: 43 (11)
Anticancer Research
Vol. 43, Issue 11
November 2023
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Intraoperative Blood Loss Impacts Recurrence and Survival in Patients With Locally Advanced Esophageal Cancer
HAYATO WATANABE, KAZUKI KANO, ITARU HASHIMOTO, MIE TANABE, SHIZUNE ONUMA, JUNYA MORITA, SHINSUKE NAGASAWA, KYOHEI KANEMATSU, TORU AOYAMA, TAKANOBU YAMADA, TAKASHI OGATA, YASUSHI RINO, AYA SAITO, TAKASHI OSHIMA
Anticancer Research Nov 2023, 43 (11) 5173-5179; DOI: 10.21873/anticanres.16718

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Intraoperative Blood Loss Impacts Recurrence and Survival in Patients With Locally Advanced Esophageal Cancer
HAYATO WATANABE, KAZUKI KANO, ITARU HASHIMOTO, MIE TANABE, SHIZUNE ONUMA, JUNYA MORITA, SHINSUKE NAGASAWA, KYOHEI KANEMATSU, TORU AOYAMA, TAKANOBU YAMADA, TAKASHI OGATA, YASUSHI RINO, AYA SAITO, TAKASHI OSHIMA
Anticancer Research Nov 2023, 43 (11) 5173-5179; DOI: 10.21873/anticanres.16718
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Keywords

  • esophageal squamous cell carcinoma
  • Intraoperative blood loss
  • survival
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