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Research ArticleClinical Studies

A Novel Filtration Membrane for Clustered Circulating Tumor Cell Extraction: A Prospective Feasibility Study

NORIYOSHI SAWABATA, KOHEI MORITA, SHIGENOBU TATSUMI, TOMOMI FUJII, TAKESHI NISHIKAWA, TAKESHI KAWAGUCHI, TORU ARAKANE, YOSHIAKI TOMINAGA, HIROKAZU SAKAGUCHI, TARO KOBAYASHI, SHIGETO HONTSU, YOSHIFUMI YAMAMOTO, NOBUHIRO FUJIOKA, NORIKO OUJI-SAGESHIMA, TOSHIHIRO ITO and CHIHO OHBAYASHI
Anticancer Research October 2023, 43 (10) 4683-4690; DOI: https://doi.org/10.21873/anticanres.16664
NORIYOSHI SAWABATA
1Department of Thoracic and Cardio-Vascular Surgery, Nara Medical University School of Medicine, Kashihara, Japan;
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  • For correspondence: nsawabata@hotmail.com
KOHEI MORITA
2Department of Diagnostic Pathology, Nara Medical University School of Medicine, Kashihara, Japan;
3Department of Diagnostic Pathology, Nara Prefecture General Medical Center, Nara, Japan;
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SHIGENOBU TATSUMI
4Department of Pathology and Diagnosis, Nara Medical University Hospital, Kashihara, Japan;
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TOMOMI FUJII
2Department of Diagnostic Pathology, Nara Medical University School of Medicine, Kashihara, Japan;
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TAKESHI NISHIKAWA
4Department of Pathology and Diagnosis, Nara Medical University Hospital, Kashihara, Japan;
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TAKESHI KAWAGUCHI
1Department of Thoracic and Cardio-Vascular Surgery, Nara Medical University School of Medicine, Kashihara, Japan;
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TORU ARAKANE
5Toray Industries, Inc., Tokyo, Japan;
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YOSHIAKI TOMINAGA
5Toray Industries, Inc., Tokyo, Japan;
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HIROKAZU SAKAGUCHI
5Toray Industries, Inc., Tokyo, Japan;
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TARO KOBAYASHI
6Ikeda Scientific co., Ltd., Tokyo, Japan;
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SHIGETO HONTSU
7Department of Respiratory Medicine, Nara Medical University School of Medicine, Kashihara, Japan;
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YOSHIFUMI YAMAMOTO
7Department of Respiratory Medicine, Nara Medical University School of Medicine, Kashihara, Japan;
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NOBUHIRO FUJIOKA
7Department of Respiratory Medicine, Nara Medical University School of Medicine, Kashihara, Japan;
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NORIKO OUJI-SAGESHIMA
8Department of Immunology, Nara Medical University School of Medicine, Kashihara, Japan
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TOSHIHIRO ITO
8Department of Immunology, Nara Medical University School of Medicine, Kashihara, Japan
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CHIHO OHBAYASHI
2Department of Diagnostic Pathology, Nara Medical University School of Medicine, Kashihara, Japan;
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Abstract

Background/Aim: Circulating tumor cells (CTCs) have garnered attention as biomarkers for therapeutic response and prognosis in malignant neoplasms. Nonetheless, existing literature predominantly relies on surrogate markers of tumor cells or focuses on single-cell CTC, failing to adequately address the challenge of detecting cluster-forming CTCs, which bear considerable prognostic implications. This prospective study aims to validate the efficacy of a novel filtration membrane, namely Soft Micro Pore Filter (S-MPF®), for rare cell recovery in detecting CTCs through the analysis of clinical samples. Patients and Methods: Patients with confirmed lung cancer or highly suspected lung cancer based on specific criteria (solid tumor size >2.0 cm, serum carcinoembryonic level >7.5 ng/ml, maximum standard uptake value derived from fluorodeoxyglucose-position emission tomography >2.9) were included in the study. CTCs were extracted from preoperative peripheral arterial blood samples using S-MPF®, and the validity of the filtration system was positively verified. Results: Out of the 25 enrolled patients, 23 had lung cancer. CTC positivity was observed in 17 cases (73.9%), whereas cluster CTC positivity was observed in 16 cases (69.6%), with a median count of two clusters. Single CTC positivity was observed in 11 cases (52.1%), with a median count of one cell. Conclusion: The utilization of the newly developed S-MPF® filtration membrane exhibited a high rate of CTC identification, demonstrating its suitability for clinical applications.

Key Words:
  • Circulating tumor cell
  • lung cancer
  • size selection
  • filter
  • validation test
  • Received July 29, 2023.
  • Revision received August 26, 2023.
  • Accepted August 28, 2023.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 43 (10)
Anticancer Research
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October 2023
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A Novel Filtration Membrane for Clustered Circulating Tumor Cell Extraction: A Prospective Feasibility Study
NORIYOSHI SAWABATA, KOHEI MORITA, SHIGENOBU TATSUMI, TOMOMI FUJII, TAKESHI NISHIKAWA, TAKESHI KAWAGUCHI, TORU ARAKANE, YOSHIAKI TOMINAGA, HIROKAZU SAKAGUCHI, TARO KOBAYASHI, SHIGETO HONTSU, YOSHIFUMI YAMAMOTO, NOBUHIRO FUJIOKA, NORIKO OUJI-SAGESHIMA, TOSHIHIRO ITO, CHIHO OHBAYASHI
Anticancer Research Oct 2023, 43 (10) 4683-4690; DOI: 10.21873/anticanres.16664

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A Novel Filtration Membrane for Clustered Circulating Tumor Cell Extraction: A Prospective Feasibility Study
NORIYOSHI SAWABATA, KOHEI MORITA, SHIGENOBU TATSUMI, TOMOMI FUJII, TAKESHI NISHIKAWA, TAKESHI KAWAGUCHI, TORU ARAKANE, YOSHIAKI TOMINAGA, HIROKAZU SAKAGUCHI, TARO KOBAYASHI, SHIGETO HONTSU, YOSHIFUMI YAMAMOTO, NOBUHIRO FUJIOKA, NORIKO OUJI-SAGESHIMA, TOSHIHIRO ITO, CHIHO OHBAYASHI
Anticancer Research Oct 2023, 43 (10) 4683-4690; DOI: 10.21873/anticanres.16664
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Keywords

  • Circulating tumor cell
  • Lung cancer
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  • validation test
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