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Research ArticleClinical Studies

RBM17 Expression Is Associated With the Efficacy of ICI Monotherapy in NSCLC With Low PD-L1 Expression

HIROAKI NAGAMINE, MASAKAZU YASHIRO, NAOKI YOSHIMOTO, MOTOHIRO IZUMI, AKIRA SUGIMOTO, KENJI NAKAHAMA, KOICHI OGAWA, YOSHIYA MATSUMOTO, KENJI SAWA, YOKO TANI, HIROYASU KANEDA, SHIGEKI MITSUOKA, KAZUHIRO YAMADA, TETSUYA WATANABE, KAZUHISA AASAI, KAZUHIRO FUKUMURA, AKILA MAYEDA and TOMOYA KAWAGUCHI
Anticancer Research October 2023, 43 (10) 4663-4672; DOI: https://doi.org/10.21873/anticanres.16662
HIROAKI NAGAMINE
1Department of Respiratory Medicine, Osaka City University, Graduate School of Medicine, Osaka, Japan;
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MASAKAZU YASHIRO
2Molecular Oncology and Therapeutics, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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  • For correspondence: i21496f@omu.ac.jp
NAOKI YOSHIMOTO
3Department of Pulmonary Medicine, Ishikiriseiki Hospital, Higashiosaka, Japan;
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MOTOHIRO IZUMI
4Department of Pulmonary Medicine, Bell land General Hospital, Sakai, Japan;
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AKIRA SUGIMOTO
5Department of Respiratory Medicine, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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KENJI NAKAHAMA
5Department of Respiratory Medicine, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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KOICHI OGAWA
5Department of Respiratory Medicine, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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YOSHIYA MATSUMOTO
5Department of Respiratory Medicine, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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KENJI SAWA
5Department of Respiratory Medicine, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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YOKO TANI
6Department of Clinical Oncology, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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HIROYASU KANEDA
6Department of Clinical Oncology, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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SHIGEKI MITSUOKA
6Department of Clinical Oncology, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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KAZUHIRO YAMADA
5Department of Respiratory Medicine, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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TETSUYA WATANABE
5Department of Respiratory Medicine, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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KAZUHISA AASAI
5Department of Respiratory Medicine, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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KAZUHIRO FUKUMURA
7Division of Gene Expression Mechanism, Center for Medical Science, Fujita Health University, Toyoake, Japan
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AKILA MAYEDA
7Division of Gene Expression Mechanism, Center for Medical Science, Fujita Health University, Toyoake, Japan
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TOMOYA KAWAGUCHI
5Department of Respiratory Medicine, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
6Department of Clinical Oncology, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan;
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Anticancer Research: 43 (10)
Anticancer Research
Vol. 43, Issue 10
October 2023
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RBM17 Expression Is Associated With the Efficacy of ICI Monotherapy in NSCLC With Low PD-L1 Expression
HIROAKI NAGAMINE, MASAKAZU YASHIRO, NAOKI YOSHIMOTO, MOTOHIRO IZUMI, AKIRA SUGIMOTO, KENJI NAKAHAMA, KOICHI OGAWA, YOSHIYA MATSUMOTO, KENJI SAWA, YOKO TANI, HIROYASU KANEDA, SHIGEKI MITSUOKA, KAZUHIRO YAMADA, TETSUYA WATANABE, KAZUHISA AASAI, KAZUHIRO FUKUMURA, AKILA MAYEDA, TOMOYA KAWAGUCHI
Anticancer Research Oct 2023, 43 (10) 4663-4672; DOI: 10.21873/anticanres.16662

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RBM17 Expression Is Associated With the Efficacy of ICI Monotherapy in NSCLC With Low PD-L1 Expression
HIROAKI NAGAMINE, MASAKAZU YASHIRO, NAOKI YOSHIMOTO, MOTOHIRO IZUMI, AKIRA SUGIMOTO, KENJI NAKAHAMA, KOICHI OGAWA, YOSHIYA MATSUMOTO, KENJI SAWA, YOKO TANI, HIROYASU KANEDA, SHIGEKI MITSUOKA, KAZUHIRO YAMADA, TETSUYA WATANABE, KAZUHISA AASAI, KAZUHIRO FUKUMURA, AKILA MAYEDA, TOMOYA KAWAGUCHI
Anticancer Research Oct 2023, 43 (10) 4663-4672; DOI: 10.21873/anticanres.16662
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Keywords

  • Splicing factor
  • RBM17/SPF45
  • non-small cell lung cancer
  • immune checkpoint inhibitor
  • chemotherapy
  • predictive marker
  • chemosensitivity
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