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Research ArticleClinical Studies

The Efficacy and Safety of a Low Relative Dose Intensity of Cabazitaxel in Patients With Metastatic Castration-resistant Prostate Cancer

FUMIHIKO URABE, DAIGO KOBAYASHI, KOSUKE IWATANI, YU IMAI, HAJIME ONUMA, KOICHI AIKAWA, TAKAFUMI YANAGISAWA, KOJIRO TASHIRO, HIROSHI SASAKI, JUN MIKI, KENTA MIKI and TAKAHIRO KIMURA
Anticancer Research October 2023, 43 (10) 4611-4617; DOI: https://doi.org/10.21873/anticanres.16655
FUMIHIKO URABE
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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DAIGO KOBAYASHI
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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KOSUKE IWATANI
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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YU IMAI
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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HAJIME ONUMA
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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KOICHI AIKAWA
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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TAKAFUMI YANAGISAWA
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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KOJIRO TASHIRO
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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HIROSHI SASAKI
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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JUN MIKI
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
2Department of Urology, The Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan
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KENTA MIKI
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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TAKAHIRO KIMURA
1Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;
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  • For correspondence: tkimura{at}jikei.ac.jp
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    Figure 1.

    Maximum PSA response rate of patients. A) Waterfall plot of maximum PSA response rate in the relative dose intensity (RDI) ≤60% group. B) Waterfall plot of maximum PSA response rate in the RDI >60% group.

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    Figure 2.

    Oncological outcomes of patients. A) Kaplan-Meier curves of progression-free survival (PFS) after initiating cabazitaxel treatment stratified by relative dose intensity (RDI) >60% and RDI ≤60%. The solid and dotted lines indicate a PFS of patients in the RDI >60% and RDI ≤60% groups, respectively. The median PFS of patients in the RDI >60% and RDI ≤60% groups were 5 months and 2 months, respectively (p<0.01). B) Kaplan-Meier curves of overall survival (OS) after initiating cabazitaxel treatment stratified by RDI >60% and RDI ≤60%. The solid and dotted lines indicate OS of patients in the RDI >60% and RDI ≤60% groups, respectively. The median OS of patients in the RDI >60% and RDI ≤60% groups were 15 months and 6 months, respectively (p<0.01).

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Anticancer Research: 43 (10)
Anticancer Research
Vol. 43, Issue 10
October 2023
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The Efficacy and Safety of a Low Relative Dose Intensity of Cabazitaxel in Patients With Metastatic Castration-resistant Prostate Cancer
FUMIHIKO URABE, DAIGO KOBAYASHI, KOSUKE IWATANI, YU IMAI, HAJIME ONUMA, KOICHI AIKAWA, TAKAFUMI YANAGISAWA, KOJIRO TASHIRO, HIROSHI SASAKI, JUN MIKI, KENTA MIKI, TAKAHIRO KIMURA
Anticancer Research Oct 2023, 43 (10) 4611-4617; DOI: 10.21873/anticanres.16655

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The Efficacy and Safety of a Low Relative Dose Intensity of Cabazitaxel in Patients With Metastatic Castration-resistant Prostate Cancer
FUMIHIKO URABE, DAIGO KOBAYASHI, KOSUKE IWATANI, YU IMAI, HAJIME ONUMA, KOICHI AIKAWA, TAKAFUMI YANAGISAWA, KOJIRO TASHIRO, HIROSHI SASAKI, JUN MIKI, KENTA MIKI, TAKAHIRO KIMURA
Anticancer Research Oct 2023, 43 (10) 4611-4617; DOI: 10.21873/anticanres.16655
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  • Risk Factors and Clinical Significance of Grade >=3 Neutropenia During the First Cycle of Cabazitaxel Therapy With Primary Pegfilgrastim Prophylaxis in Metastatic Castration-resistant Prostate Cancer
  • Patients Diagnosed With Metastatic Castration-sensitive Prostate Cancer and High Serum Lactate Dehydrogenase Levels Did Not Receive an Adequate Dose of Cabazitaxel
  • Impact of Novel Agents on Patient Characteristics, Treatment Patterns, and Outcomes in Patients With Metastatic Castration-resistant Prostate Cancer
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Keywords

  • Metastatic castration-resistant prostate cancer
  • cabazitaxel
  • relative dose intensity
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