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Research ArticleClinical Studies

Drugs Showing Real-world Efficacy for Nocturia in Patients With Bladder Storage Symptoms

KAZUNA TSUBOUCHI, NAOTAKA GUNGE, WATARU MATSUOKA, TAIKI EMOTO, TAKESHI MIYAZAKI, KOSUKE TOMINAGA, YU OKABE, HIROSHI MATSUZAKI, SHINTARO ASO, MASAHIRO TACHIBANA, CHIZURU NAKAGAWA, AIKO FUJIKAWA, NOBUYUKI NAKAMURA, HIROFUMI MATSUOKA and NOBUHIRO HAGA
Anticancer Research January 2023, 43 (1) 455-461; DOI: https://doi.org/10.21873/anticanres.16182
KAZUNA TSUBOUCHI
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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NAOTAKA GUNGE
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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WATARU MATSUOKA
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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TAIKI EMOTO
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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TAKESHI MIYAZAKI
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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KOSUKE TOMINAGA
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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YU OKABE
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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HIROSHI MATSUZAKI
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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SHINTARO ASO
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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MASAHIRO TACHIBANA
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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CHIZURU NAKAGAWA
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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AIKO FUJIKAWA
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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NOBUYUKI NAKAMURA
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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HIROFUMI MATSUOKA
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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NOBUHIRO HAGA
Department of Urology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
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  • For correspondence: nhaga@fukuoka-u.ac.jp
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Abstract

Background/Aim: Nocturia is defined as the symptom that an individual has to disrupt their sleep at night, for one or several times, in order to void. Nocturia is a bothersome event that markedly reduces a patient’s quality of life. The aim of the study was to elucidate which drugs, prescribed to reduce nocturia, show real-world efficacy in patients with bladder storage symptoms. Patients and Methods: One hundred consecutive patients who visited the Fukuoka University Medical Center were evaluated between May and July 2022. Anticholinergic drugs, β3 adrenoceptor agonists, α1 blockers, desmopressin, and other medicines were prescribed for relieving nocturia. Desmopressin was used as second-line treatment of nocturia only in males with nocturnal polyuria. The association between each drug and actual decrease in nocturia was investigated using multivariate analysis. Results: The number of nocturia episodes was reduced in patients using anticholinergic drugs, β3 adrenoceptor agonists, and desmopressin (−1.4±0.9, −1.3±0.9, −2.0 ±0.8 episodes/night, respectively). Multivariate analysis for the entire cohort showed that anticholinergic drugs and β3 adrenoceptor agonists were associated with significantly decreased nocturia episodes (p=0.01 and p=0.04, respectively). In males, only desmopressin was associated with a significant decrease in nocturia (p=0.03), and combination therapy significantly decreased the number of nocturia episodes compared to monotherapy (p=0.001). Conclusion: In a real-world clinical setting, anticholinergic drugs and β3 adrenoceptor agonists were similarly effective in reducing nocturia. Administration of desmopressin combined with anticholinergic drugs and/or β3 adrenoceptor agonists is the most effective method for reducing nocturia in male patients with both storage symptoms and nocturnal polyuria.

Key Words:
  • Desmopressin
  • nocturia
  • LUTS
  • β3 adrenoceptor agonist
  • Received September 27, 2022.
  • Revision received October 13, 2022.
  • Accepted October 20, 2022.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 43 (1)
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Drugs Showing Real-world Efficacy for Nocturia in Patients With Bladder Storage Symptoms
KAZUNA TSUBOUCHI, NAOTAKA GUNGE, WATARU MATSUOKA, TAIKI EMOTO, TAKESHI MIYAZAKI, KOSUKE TOMINAGA, YU OKABE, HIROSHI MATSUZAKI, SHINTARO ASO, MASAHIRO TACHIBANA, CHIZURU NAKAGAWA, AIKO FUJIKAWA, NOBUYUKI NAKAMURA, HIROFUMI MATSUOKA, NOBUHIRO HAGA
Anticancer Research Jan 2023, 43 (1) 455-461; DOI: 10.21873/anticanres.16182

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Drugs Showing Real-world Efficacy for Nocturia in Patients With Bladder Storage Symptoms
KAZUNA TSUBOUCHI, NAOTAKA GUNGE, WATARU MATSUOKA, TAIKI EMOTO, TAKESHI MIYAZAKI, KOSUKE TOMINAGA, YU OKABE, HIROSHI MATSUZAKI, SHINTARO ASO, MASAHIRO TACHIBANA, CHIZURU NAKAGAWA, AIKO FUJIKAWA, NOBUYUKI NAKAMURA, HIROFUMI MATSUOKA, NOBUHIRO HAGA
Anticancer Research Jan 2023, 43 (1) 455-461; DOI: 10.21873/anticanres.16182
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Keywords

  • Desmopressin
  • nocturia
  • LUTS
  • β3 adrenoceptor agonist
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