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Research ArticleExperimental Studies

miR-877-3p as a Potential Tumour Suppressor of Oesophageal Squamous Cell Carcinoma

TAKUMA FUKUDA, HAYATO BABA, TOMOYUKI OKUMURA, MITSURO KANDA, TAKAHISA AKASHI, HARUYOSHI TANAKA, TAKESHI MIWA, TORU WATANABE, KATSUHISA HIRANO, SHINICHI SEKINE, ISAYA HASHIMOTO, KAZUTO SHIBUYA, SHOZO HOJO, ISAKU YOSHIOKA, KOSHI MATSUI, YASUHIRO KODERA and TSUTOMU FUJII
Anticancer Research January 2023, 43 (1) 35-43; DOI: https://doi.org/10.21873/anticanres.16131
TAKUMA FUKUDA
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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HAYATO BABA
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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  • For correspondence: hayato.bb@gmail.com
TOMOYUKI OKUMURA
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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MITSURO KANDA
2Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
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TAKAHISA AKASHI
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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HARUYOSHI TANAKA
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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TAKESHI MIWA
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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TORU WATANABE
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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KATSUHISA HIRANO
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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SHINICHI SEKINE
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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ISAYA HASHIMOTO
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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KAZUTO SHIBUYA
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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SHOZO HOJO
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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ISAKU YOSHIOKA
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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KOSHI MATSUI
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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YASUHIRO KODERA
2Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
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TSUTOMU FUJII
1Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan;
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Abstract

Background/Aim: MicroRNAs (miRNAs) are abnormally expressed and involved in the pathogenesis of various carcinomas. The present study aimed to identify novel miRNA genes associated with the pathogenesis and prognosis of oesophageal squamous cell carcinoma (ESCC). Materials and Methods: The miRNA profiling of 873 genes was performed using surgically resected oesophageal tissues from 35 patients with ESCC to identify candidate miRNAs. To examine the biological activities of candidate miRNAs, their proliferative, invasive, and migratory abilities were evaluated in ESCC cells subjected to miRNA mimic-mediated over-expression. The miRNA expression levels of the selected candidate miRNAs were analysed in the resected oesophageal tissues of 76 patients with ESCC from the two cohorts and correlated with the clinicopathological parameters. Results: Among the four candidate miRNAs identified by miRNA profiling, miR-877-3p was selected for subsequent analyses. In vitro analyses showed that the over-expression of miR-877-3p significantly suppressed the proliferation, invasion, and migration of ESCC cell lines compared with those of control cells. In the analyses of clinical specimens, the expression of miR-877-3p was down-regulated in ESCC tissues compared with that in adjacent normal oesophageal tissues. The down-regulation of miR-877-3p expression in ESCC tissues was significantly associated with advanced local progression and lymphatic involvement. The miR-877-3p down-regulation was also significantly associated with poor disease-free and disease-specific survival. Conclusion: miR-877-3p acts as a tumour suppressor gene in ESCC cells, and its down-regulation in ESCC tissues is associated with a poor prognosis. Thus, miR-877-3p may serve as a novel prognostic marker and promising therapeutic target.

Key Words:
  • Oesophageal Squamous Cell Carcinoma
  • miR-877-3p
  • Received November 3, 2022.
  • Revision received November 10, 2022.
  • Accepted November 11, 2022.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 43 (1)
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miR-877-3p as a Potential Tumour Suppressor of Oesophageal Squamous Cell Carcinoma
TAKUMA FUKUDA, HAYATO BABA, TOMOYUKI OKUMURA, MITSURO KANDA, TAKAHISA AKASHI, HARUYOSHI TANAKA, TAKESHI MIWA, TORU WATANABE, KATSUHISA HIRANO, SHINICHI SEKINE, ISAYA HASHIMOTO, KAZUTO SHIBUYA, SHOZO HOJO, ISAKU YOSHIOKA, KOSHI MATSUI, YASUHIRO KODERA, TSUTOMU FUJII
Anticancer Research Jan 2023, 43 (1) 35-43; DOI: 10.21873/anticanres.16131

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miR-877-3p as a Potential Tumour Suppressor of Oesophageal Squamous Cell Carcinoma
TAKUMA FUKUDA, HAYATO BABA, TOMOYUKI OKUMURA, MITSURO KANDA, TAKAHISA AKASHI, HARUYOSHI TANAKA, TAKESHI MIWA, TORU WATANABE, KATSUHISA HIRANO, SHINICHI SEKINE, ISAYA HASHIMOTO, KAZUTO SHIBUYA, SHOZO HOJO, ISAKU YOSHIOKA, KOSHI MATSUI, YASUHIRO KODERA, TSUTOMU FUJII
Anticancer Research Jan 2023, 43 (1) 35-43; DOI: 10.21873/anticanres.16131
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Keywords

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