Research ArticleExperimental Studies

Genetic and Transcriptional Analysis of 8q24.21 Cluster in Gastric Cancer

BRUNNO SANTOS PEREIRA, FERNANDA WISNIESKI, DANIELLE QUEIROZ CALCAGNO, LEONARDO CAIRES SANTOS, CAROLINA OLIVEIRA GIGEK, ELIZABETH SUCHI CHEN, LUCAS TREVIZANI RASMUSSEN, SPENCER LUIZ MARQUES PAYÃO, RENATA SANCHES ALMEIDA, CAMILA ALBUQUERQUE PINTO, BRUNO TAKAO REAL KARIA, RICARDO ARTIGIANI, SAMIA DEMACHKI, PAULO PIMENTEL ASSUMPÇÃO, LAERCIO GOMES LOURENÇO, CARLOS HARUO ARASAKI, ROMMEL RODRÍGUEZ BURBANO, MARIANA FERREIRA LEAL and MARILIA ARRUDA CARDOSO SMITH
Anticancer Research September 2022, 42 (9) 4381-4394; DOI: https://doi.org/10.21873/anticanres.15938

Article Figures & Data

Figures

  • Figure 1.
    Figure 1.

    Analysis of FAM49B, FAM84B, GSDMC and miR-5194 gene expression. (a) Expression of FAM49B in 85 pairs of tumoral and adjacent non-tumoral gastric samples and 29 gastric control samples. (b) Expression of FAM84B in 51 pairs of tumoral and adjacent non-tumoral gastric samples and 29 gastric control samples. (c) Expression of GSDMC in 52 pairs of tumoral and adjacent non-tumoral gastric samples and 26 gastric control samples. (d) Expression of miR-5194 in 77 pairs of tumoral and adjacent non-tumoral gastric samples and 29 gastric control samples. Data are expressed as median±95% confidence interval. *p<0.05 by Mann-Whitney test. **p<0.05 by Wilcoxon test.

  • Figure 2.
    Figure 2.

    Survival analysis. (a) Survival analysis of GC patients with high (N=27) and low (N=25) expression of FAM49B. (b) Survival analysis of GC patients with high (N=16) and low (N=10) expression of FAM84B. (c) Survival analysis of GC patients with high (N=8) and low (N=22) expression of GSDMC. (d) Survival analysis of GC patients with high (N=20) and low (N=26) expression of miR-5194. Data are expressed as 2−ΔCRT.

  • Figure 3.
    Figure 3.

    Analysis of gene expression and clinicopathological associations. (a) Association of higher GSDMC transcriptional levels with tumors T3 and T4 (N=34) compared to tumors T1 and T2 (N=18). (b) Association of higher GSDMC transcriptional levels with tumors on stage III and IV (N=21) compared to tumors on stage I and II (N=31). (c) Association of higher GSDMC transcriptional levels with advanced tumors (N=42) compared to early tumors (N=10). Data are expressed as median±95% confidence interval. *p<0.05 by Mann-Whitney test.

  • Figure 4.
    Figure 4.

    Analysis of copy number variation and clinicopathological associations. (a) Association of increased FAM49B copy number with intestinal type tumors (N=82). (b) Association of increased FAM49B copy number with well/moderately differentiated tumors (N=81). (c) Association of increased FAM84B copy number with well/moderately differentiated tumors (N=49). (d) Association of increased GSDMC copy number with intestinal type tumors (N=50). (e) Association of increased GSDMC copy number with well/moderately differentiated tumors (N=50). Data are expressed as % of samples. *p≤0.05 by Chi-squared test.

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Genetic and Transcriptional Analysis of 8q24.21 Cluster in Gastric Cancer
BRUNNO SANTOS PEREIRA, FERNANDA WISNIESKI, DANIELLE QUEIROZ CALCAGNO, LEONARDO CAIRES SANTOS, CAROLINA OLIVEIRA GIGEK, ELIZABETH SUCHI CHEN, LUCAS TREVIZANI RASMUSSEN, SPENCER LUIZ MARQUES PAYÃO, RENATA SANCHES ALMEIDA, CAMILA ALBUQUERQUE PINTO, BRUNO TAKAO REAL KARIA, RICARDO ARTIGIANI, SAMIA DEMACHKI, PAULO PIMENTEL ASSUMPÇÃO, LAERCIO GOMES LOURENÇO, CARLOS HARUO ARASAKI, ROMMEL RODRÍGUEZ BURBANO, MARIANA FERREIRA LEAL, MARILIA ARRUDA CARDOSO SMITH
Anticancer Research Sep 2022, 42 (9) 4381-4394; DOI: 10.21873/anticanres.15938
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