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Research ArticleClinical Studies

Adjuvant Concurrent Chemoradiotherapy Versus Adjuvant Chemotherapy Only in Locally Advanced Non-small-cell Lung Cancer With Involved Microscopic Resection Margin: A Population-based Cohort Study

CHIH-YEN TU, HUNG-JEN CHEN, TE-CHUN HSIA, HSIN-YUAN FANG, CHIA-CHIN LI and CHUN-RU CHIEN
Anticancer Research June 2022, 42 (6) 3195-3201; DOI: https://doi.org/10.21873/anticanres.15809
CHIH-YEN TU
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
2School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.;
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HUNG-JEN CHEN
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
2School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.;
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TE-CHUN HSIA
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
3Ph.D. Program for Health Science and Industry, College of Health Care, China Medical University, Taichung, Taiwan, R.O.C.;
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HSIN-YUAN FANG
2School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.;
4Department of Chest Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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CHIA-CHIN LI
5Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
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CHUN-RU CHIEN
2School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.;
5Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
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  • For correspondence: d16181@mail.cmu.edu.tw d16181@gmail.com
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Abstract

Background/Aim: The role of adjuvant concurrent chemoradiotherapy (aCCRT) for locally advanced non-small cell lung cancer (LA-NSCLC) treated with radical surgery, with microscopically involved resection margin, has been debated without there being any direct evidence. In this study, we aimed to compare the outcomes between aCCRT and adjuvant chemotherapy (aCT). Patients and Methods: Eligible patients diagnosed within 2011-2018 with LA-NSCLC were identified via the Taiwan Cancer Registry. We used propensity-score weighting to balance observable potential confounders, and then compared the hazard ratios of death between aCCRT-treated vs. aCT-treated groups. We also performed supplementary analyses using propensityscore matching. Results: Our main study population consisted of 82 patients. The propensity score weight-adjusted hazard ratio of death for the aCCRT group was 0.74 (95% confidence interval=0.35-1.56, p=0.43). There was also no statistically significant difference in survival between groups in the supplementary analyses. Conclusion: For patients treated with radical but R1 resection for LA-NSCLC, there was no significant OS benefit from the addition of concurrent radiotherapy.

Key Words:
  • Adjuvant concurrent chemoradiotherapy
  • adjuvant chemotherapy
  • propensity score
  • resection margin
  • Received February 25, 2022.
  • Revision received May 5, 2022.
  • Accepted May 19, 2022.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 42 (6)
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Adjuvant Concurrent Chemoradiotherapy Versus Adjuvant Chemotherapy Only in Locally Advanced Non-small-cell Lung Cancer With Involved Microscopic Resection Margin: A Population-based Cohort Study
CHIH-YEN TU, HUNG-JEN CHEN, TE-CHUN HSIA, HSIN-YUAN FANG, CHIA-CHIN LI, CHUN-RU CHIEN
Anticancer Research Jun 2022, 42 (6) 3195-3201; DOI: 10.21873/anticanres.15809

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Adjuvant Concurrent Chemoradiotherapy Versus Adjuvant Chemotherapy Only in Locally Advanced Non-small-cell Lung Cancer With Involved Microscopic Resection Margin: A Population-based Cohort Study
CHIH-YEN TU, HUNG-JEN CHEN, TE-CHUN HSIA, HSIN-YUAN FANG, CHIA-CHIN LI, CHUN-RU CHIEN
Anticancer Research Jun 2022, 42 (6) 3195-3201; DOI: 10.21873/anticanres.15809
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