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Research ArticleClinical Studies

Preoperative S-1 Therapy for Head and Neck Carcinoma During the Waiting Period Before Surgery

TAKASHI MATSUKI, CHIHIRO FUSHIMI, SHUNSUKE MIYAMOTO, HIDEAKI TAKAHASHI, TATSUO MASUBUCHI, YUICHIRO TADA, KOUKI MIURA, SHIN-ETSU KAMATA, KOICHI KANO, SHOHEI TSUTSUMI, KAHO MOMIYAMA and TAKU YAMASHITA
Anticancer Research June 2022, 42 (6) 3177-3183; DOI: https://doi.org/10.21873/anticanres.15807
TAKASHI MATSUKI
1Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Japan;
2Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan;
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  • For correspondence: matsuki@med.kitasato-u.ac.jp
CHIHIRO FUSHIMI
2Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan;
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SHUNSUKE MIYAMOTO
1Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Japan;
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HIDEAKI TAKAHASHI
3Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University Graduate School of Medical Sciences, Yokohama, Japan
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TATSUO MASUBUCHI
2Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan;
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YUICHIRO TADA
2Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan;
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KOUKI MIURA
2Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan;
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SHIN-ETSU KAMATA
2Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan;
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KOICHI KANO
1Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Japan;
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SHOHEI TSUTSUMI
1Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Japan;
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KAHO MOMIYAMA
1Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Japan;
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TAKU YAMASHITA
1Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Sagamihara, Japan;
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Abstract

Background/Aim: In patients with squamous cell carcinoma of the head and neck (SCCHN), delayed surgery can result in poorer postoperative function and prognosis due to the growth of the tumor and extended surgery. Further, delay may even make the tumor unresectable. To prevent tumor growth during the waiting period before surgery, S-1 has been administrated preoperatively at several facilities in Japan. To date, however, the safety and efficacy of preoperative S-1 remain unclear. Patients and Methods: We conducted a retrospective cohort study of 118 patients with SCCHN treated with S-1 before radical surgery at 2 institutions in Japan. We evaluated the safety of S-1 therapy, which was evaluated by the incidence of grade 3 or greater adverse events (AEs). The rate of achievement of non-growth of tumors was also calculated. Results: Regarding safety, 125 AEs of all grades were recorded in 71 patients (60%). Of these, grade 3 AEs were detected in 3 patients (3%), and no grade 4 or 5 AEs occurred. The nongrowth rate of primary lesions and lymph node metastases was 89% and 85%, respectively. Conclusion: Preoperative S-1 therapy might be useful, with acceptable toxicity, on an outpatient basis in patients with SCCHN.

Key Words:
  • Head and neck squamous cell carcinoma
  • S-1
  • preoperative chemotherapy
  • surgical case
  • adverse event
  • Received April 7, 2022.
  • Revision received May 5, 2022.
  • Accepted May 9, 2022.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 42 (6)
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June 2022
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Preoperative S-1 Therapy for Head and Neck Carcinoma During the Waiting Period Before Surgery
TAKASHI MATSUKI, CHIHIRO FUSHIMI, SHUNSUKE MIYAMOTO, HIDEAKI TAKAHASHI, TATSUO MASUBUCHI, YUICHIRO TADA, KOUKI MIURA, SHIN-ETSU KAMATA, KOICHI KANO, SHOHEI TSUTSUMI, KAHO MOMIYAMA, TAKU YAMASHITA
Anticancer Research Jun 2022, 42 (6) 3177-3183; DOI: 10.21873/anticanres.15807

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Preoperative S-1 Therapy for Head and Neck Carcinoma During the Waiting Period Before Surgery
TAKASHI MATSUKI, CHIHIRO FUSHIMI, SHUNSUKE MIYAMOTO, HIDEAKI TAKAHASHI, TATSUO MASUBUCHI, YUICHIRO TADA, KOUKI MIURA, SHIN-ETSU KAMATA, KOICHI KANO, SHOHEI TSUTSUMI, KAHO MOMIYAMA, TAKU YAMASHITA
Anticancer Research Jun 2022, 42 (6) 3177-3183; DOI: 10.21873/anticanres.15807
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Keywords

  • Head and neck squamous cell carcinoma
  • S-1
  • preoperative chemotherapy
  • surgical case
  • adverse event
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