Preparation of Micelles Encapsulating Doxorubicin and Their Anticancer Effect in Combination With Tranilast in 3D Spheroids and In Vivo

TERUKI NII; KANJI YOSHIKAWA; ISSEI TAKEUCHI; KIMIKO MAKINO

doi:10.21873/anticanres.15766

Research ArticleExperimental Studies

Preparation of Micelles Encapsulating Doxorubicin and Their Anticancer Effect in Combination With Tranilast in 3D Spheroids and In Vivo

TERUKI NII, KANJI YOSHIKAWA, ISSEI TAKEUCHI and KIMIKO MAKINO

Anticancer Research June 2022, 42 (6) 2847-2857; DOI: https://doi.org/10.21873/anticanres.15766

TERUKI NII

1Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka, Japan;

2Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan;

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For correspondence: nii.teruki.204@m.kyushu-u.ac.jp itakeuchi@iju.ac.jp

KANJI YOSHIKAWA

3Faculty of Pharmaceutical Sciences, Tokyo University of Sciences, Noda, Japan;

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ISSEI TAKEUCHI

3Faculty of Pharmaceutical Sciences, Tokyo University of Sciences, Noda, Japan;

4Center for Drug Delivery Research, Tokyo University of Sciences, Noda, Japan;

5Josai International University, Togane, Japan

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For correspondence: nii.teruki.204@m.kyushu-u.ac.jp itakeuchi@iju.ac.jp

KIMIKO MAKINO

3Faculty of Pharmaceutical Sciences, Tokyo University of Sciences, Noda, Japan;

4Center for Drug Delivery Research, Tokyo University of Sciences, Noda, Japan;

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Anticancer Research

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June 2022

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Preparation of Micelles Encapsulating Doxorubicin and Their Anticancer Effect in Combination With Tranilast in 3D Spheroids and In Vivo

TERUKI NII, KANJI YOSHIKAWA, ISSEI TAKEUCHI, KIMIKO MAKINO

Anticancer Research Jun 2022, 42 (6) 2847-2857; DOI: 10.21873/anticanres.15766

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Preparation of Micelles Encapsulating Doxorubicin and Their Anticancer Effect in Combination With Tranilast in 3D Spheroids and In Vivo

TERUKI NII, KANJI YOSHIKAWA, ISSEI TAKEUCHI, KIMIKO MAKINO

Anticancer Research Jun 2022, 42 (6) 2847-2857; DOI: 10.21873/anticanres.15766

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Keywords

Micelles
pH-responsive
three-dimensional cell culture
tumor microenvironment
anti-fibrotic drug
tumor-bearing mice

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