Table of Contents

Clinical Studies

• Open Access

  Cytoreductive Surgery and HIPEC for Malignant Peritoneal Mesothelioma: Outcomes and Survival From an Australian Centre

  RAPHAEL SHAMAVONIAN, ERNEST CHENG, JOSH B. KARPES, SHOMA BARAT, NIMA AHMADI and DAVID L. MORRIS

  Anticancer Research June 2022, 42 (6) 2939-2944; DOI: https://doi.org/10.21873/anticanres.15776
• Open Access

  Recurrent Mandibular Giant Cell Lesion in Neurofibromatosis Type 1: Second Hit Mutation on the NF1 Gene in the Osseous Lesion

  REINHARD E. FRIEDRICH, ANDREAS M. LUEBKE, ULRICH SCHÜLLER, CHRISTIAN HAGEL, FELIX K. KOHLRUSCH, ILSE WIELAND and MARTIN ZENKER

  Anticancer Research June 2022, 42 (6) 2945-2952; DOI: https://doi.org/10.21873/anticanres.15777
• Open Access

  Proton Beam Therapy in Elderly Patients With cT1-3N0M0 Non-small Cell Lung Cancer

  MASATOSHI NAKAMURA, HITOSHI ISHIKAWA, KAYOKO OHNISHI, KEIICHIRO BABA, TAKASHI SAITO, TAISUKE SUMIYA, MOTOHIRO MURAKAMI, YUICHI HIROSHIMA, KEI NAKAI, MASASHI MIZUMOTO, TOSHIYUKI OKUMURA and HIDEYUKI SAKURAI

  Anticancer Research June 2022, 42 (6) 2953-2960; DOI: https://doi.org/10.21873/anticanres.15778
• Open Access

  Does the Use of BioZorb^® Result in Smaller Breast Seroma Volume?

  ZEINAB ABOU YEHIA, JENNIFER YOON, MUTLAY SAYAN, SHICHA KUMAR, LARA HATHOUT, MARIA KOWZUN, LINDSAY POTDEVIN, MRIDULA GEORGE, BRUCE G. HAFFTY and NISHA OHRI

  Anticancer Research June 2022, 42 (6) 2961-2965; DOI: https://doi.org/10.21873/anticanres.15779
• Open Access

  Predictive Performance of Prospectively Applied ISUP and Fuhrman Grade in Nonmetastatic Renal Cell Carcinoma

  KRISTINA FLOR GALTUNG, PETER MÆHRE LAURITZEN, EDUARD BACO, ROLF EIGIL BERG, ANCA MIHAELA NAAS and ERIK RUD

  Anticancer Research June 2022, 42 (6) 2967-2975; DOI: https://doi.org/10.21873/anticanres.15780
• Open Access

  Neutrophil-to-Lymphocyte Ratio to Predict the Efficacy of Immune Checkpoint Inhibitor in Upper Gastrointestinal Cancer

  EISUKE BOOKA, HIROTOSHI KIKUCHI, RYOMA HANEDA, WATARU SONEDA, SANSHIRO KAWATA, TOMOHIRO MURAKAMI, TOMOHIRO MATSUMOTO, YOSHIHIRO HIRAMATSU and HIROYA TAKEUCHI

  Anticancer Research June 2022, 42 (6) 2977-2987; DOI: https://doi.org/10.21873/anticanres.15781
• Open Access

  Stereotactic Body Radiotherapy for Stage I Lung Cancer With a New Real-time Tumor Tracking System

  YUICHI HIROSHIMA, YOSHIO TAMAKI, TAKUYA SAWADA, TOSHIKI ISHIDA, KENJI YASUE, KAZUYA SHINODA, TAKASHI SAITO, TAKAYUKI KABURAGI, MORIYUKI KIYOSHIMA, TOSHIYUKI OKUMURA and HIDEYUKI SAKURAI

  Anticancer Research June 2022, 42 (6) 2989-2995; DOI: https://doi.org/10.21873/anticanres.15782
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  Early Versus Late Postoperative Radiotherapy in Patients With Prostate Cancer: Results of a Single-centre Retrospective Study

  FRANCESCO PASQUALETTI, ELISA CALISTRI, TAIUSHA FUENTES, ALDO SAINATO, BRUNO MANFREDI, RICCARDO MORGANTI, LUCA GALLI, CHIARA MERCINELLI, ENRICO SAMMARCO, DAVIDE BALDACCINI, GABRIELE CORAGGIO, MARCO PANICHI, PAOLA ANNA ERBA and FABIOLA PAIAR

  Anticancer Research June 2022, 42 (6) 2997-3001; DOI: https://doi.org/10.21873/anticanres.15783
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  Hearing Loss After Cisplatin-based Chemoradiotherapy for Locally Advanced Head and Neck Cancer: A Prospective Single-institution Study

  DANIELA MUSIO, MARCO DE VINCENTIIS, PASQUALINA D’URSO, ANGELA MUSACCHIO, VERONICA MAIURI, LUCY ZACCARO, MASSIMO RALLI, CLAUDIA MARCHETTI, ROSARIA TURCHETTA, VINCENZO TOMBOLINI and FRANCESCA DE FELICE

  Anticancer Research June 2022, 42 (6) 3003-3009; DOI: https://doi.org/10.21873/anticanres.15784
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  Detection Rate of ⁶⁸Ga-PSMA PET/CT vs. mpMRI Targeted Biopsy for Clinically Significant Prostate Cancer

  PIETRO PEPE, LUDOVICA PEPE, SEBASTIANO COSENTINO, MASSIMO IPPOLITO, MICHELE PENNISI and FILIPPO FRAGGETTA

  Anticancer Research June 2022, 42 (6) 3011-3015; DOI: https://doi.org/10.21873/anticanres.15785
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  Effects of Pegylated Liposomal Doxorubicin and CA125 Level Variability Analysis in Platinum-refractory/resistant Recurrent Ovarian Cancer

  TAKUMA OOYAMA, YUKO SHIMOJI, TADAHARU NAKASONE, YOSHIHISA ARAKAKI, YUSUKE TAIRA, TOMOKO NAKAMOTO, WATARU KUDAKA and YOICHI AOKI

  Anticancer Research June 2022, 42 (6) 3017-3022; DOI: https://doi.org/10.21873/anticanres.15786
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  Risk Stratification of Postoperative Pneumonia in Patients Undergoing Subtotal Esophagectomy for Esophageal Cancer

  KEITA TAKAHASHI, KATSUNORI NISHIKAWA, YUICHIRO TANISHIMA, YOSHITAKA ISHIKAWA, TAKANORI KUROGOCHI, MASAMI YUDA, YUJIRO TANAKA, AKIRA MATSUMOTO, FUMIAKI YANO and KEN ETO

  Anticancer Research June 2022, 42 (6) 3023-3028; DOI: https://doi.org/10.21873/anticanres.15787
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  Large Tumor Size and High Neutrophil-to-lymphocyte Ratio Predicts Poor Prognosis After Pneumonectomy or Sleeve Lobectomy in Patients With Non-small-cell Lung Cancer

  TAKUMA TSUKIOKA, NOBUHIRO IZUMI, HIROAKI KOMATSU, HIDETOSHI INOUE, RYUICHI ITO, SATOSHI SUZUKI and NORITOSHI NISHIYAMA

  Anticancer Research June 2022, 42 (6) 3029-3034; DOI: https://doi.org/10.21873/anticanres.15788
• Open Access

  The First Prognostic Tool to Estimate the Risk of Late Grade ≥3 Xerostomia in Patients Irradiated for Head-and-Neck Cancer

  DIRK RADES, BRITTA WARWAS, FLORIAN CREMERS, KARSTEN GERULL, RALPH PRIES, ANKE LEICHTLE, KARL L. BRUCHHAGE, SAMER G. HAKIM and STEVEN E. SCHILD

  Anticancer Research June 2022, 42 (6) 3035-3039; DOI: https://doi.org/10.21873/anticanres.15789
• Open Access

  Immediate Prostate-specific Antigen Decline After Enzalutamide Following Abiraterone Predicts Survival in Castration-resistant Disease

  NAOHIRO FUJIMOTO, AKINORI MINATO, TSUKASA IGAWA, TASUKU HIROSHIGE, WATARU OBARA, ATSUSHI FUKUDA, YUJIRO NAGATA, YUI MIZUSHIMA, IKKO TOMISAKI and KENICHI HARADA

  Anticancer Research June 2022, 42 (6) 3041-3047; DOI: https://doi.org/10.21873/anticanres.15790
• Open Access

  The Outcome of Conversion Liver Resection Surgery by Lenvatinib Treatment: A Single Center Experience

  MASAAKI HIDAKA, TAKANOBU HARA, AKIHIKO SOYAMA, RYU SASAKI, HAJIME MATSUSHIMA, TAKAYUKI TANAKA, TAKASHI HAMADA, HAJIME IMAMURA, TOMOHIKO ADACHI, KENGO KANETAKA, HISAMITSU MIYAAKI, SHINJI OKANO and SUSUMU EGUCHI

  Anticancer Research June 2022, 42 (6) 3049-3054; DOI: https://doi.org/10.21873/anticanres.15791
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  Preservation of Split Renal Function After Laparoscopic and Robot-assisted Partial Nephrectomy

  KOJIRO OHBA, TOMOHIRO MATSUO, KENSUKE MITSUNARI, YUICHIRO NAKAMURA, HIROMI NAKANISHI, YASUSHI MOCHIZUKI and YASUYOSHI MIYATA

  Anticancer Research June 2022, 42 (6) 3055-3060; DOI: https://doi.org/10.21873/anticanres.15792
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  Survival and Early Death Within Three Months from the Start of Immune Checkpoint Inhibitors in Patients With Different Types of Cancer

  CARSTEN NIEDER, SIV GYDA AANES and ELLINOR C. HAUKLAND

  Anticancer Research June 2022, 42 (6) 3061-3066; DOI: https://doi.org/10.21873/anticanres.15793
• Open Access

  The Effects of Treatment on Peripheral Blood Immune Cell Profile in Pancreatic Ductal Adenocarcinoma (PDAC)

  SKAISTE TULYTE, DAINIUS CHARACIEJUS, REDA MATUZEVICIENE, AUSRA JANIULIONIENE, MANTAS RADZEVICIUS, TADAS ZVIRBLIS and AUDRIUS SILEIKIS

  Anticancer Research June 2022, 42 (6) 3067-3073; DOI: https://doi.org/10.21873/anticanres.15794
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  Adverse Cardiovascular Effects of Anti-tumor Therapies in Patients With Breast Cancer: A Single-center Cross-sectional Analysis

  STEPHANIE ROSENKAIMER, TINA SIEBURG, LAURA WINTER, ATHANASIOS MAVRATZAS, WOLF-KARSTEN HOFMANN, RALF-DIETER HOFHEINZ, IBRAHIM AKIN, DANIEL DUERSCHMIED and ANNA HOHNECK

  Anticancer Research June 2022, 42 (6) 3075-3084; DOI: https://doi.org/10.21873/anticanres.15795
• Open Access

  Improvement of Sleep Disorders During a Course of Radiotherapy for Breast Cancer - Final Results of the Prospective Interventional RADIO-SLEEP Trial

  DIRK RADES, CARLOS A. NARVAEZ, LIESA DZIGGEL, LAURA SPLETTSTÖSSER, STEFAN JANSSEN, DENISE OLBRICH, STEVEN E. SCHILD, SØREN TVILSTED and TROELS W. KJAER

  Anticancer Research June 2022, 42 (6) 3085-3089; DOI: https://doi.org/10.21873/anticanres.15796
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  Utility of Drain Fluid Culture and Gram Stain in Early Intervention for Occult Anastomotic Leakage in Colorectal Cancer

  TETSURO TOMINAGA, TAKASHI NONAKA, SHOSABURO OYAMA, YUMA TAKAMURA, SHINTARO HASHIMOTO, TOSHIO SHIRAISHI, TERUMITSU SAWAI and TAKESHI NAGAYASU

  Anticancer Research June 2022, 42 (6) 3091-3098; DOI: https://doi.org/10.21873/anticanres.15797
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  Efficacy of Androgen Receptor-targeted Drugs After Prostate Cancer Recurrence With Bone Metastases: PROSTAT-BSI Sub-analysis

  TAIKI KAMIJIMA, HIROSHI YAEGASHI, ATSUSHI MIZOKAMI, KENICHI NAKAJIMA, HIDEYASU MATSUYAMA, TOMOHIKO ICHIKAWA, KOSHIRO NISHIMOTO, SATORU TAKAHASHI, HIROAKI SHIINA, HIROYUKI HORIKOSHI, KATSUYOSHI HASHINE, YUTAKA SUGIYAMA, TAKESHI MIYAO, MANABU KAMIYAMA, KENICHI HARADA, AKITO ITO and HIDEKI ENOKIDA

  Anticancer Research June 2022, 42 (6) 3099-3108; DOI: https://doi.org/10.21873/anticanres.15798
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  Evaluation of Lung Toxicity Related to the Treatment With Alectinib Using a Pharmacovigilance Database

  JUNYA SATO, MAYAKO UCHIDA, HARUKA WAKABAYASHI and TADASHI SHIMIZU

  Anticancer Research June 2022, 42 (6) 3109-3116; DOI: https://doi.org/10.21873/anticanres.15799
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  Control and Risk Factors of Nausea and Vomiting in Patients With Cervical Cancer Receiving Radiotherapy

  AKANE UNO, SENRI YAMAMOTO, HIROTOSHI IIHARA, HIRONORI FUJII, CHIYOKO MAKITA, YOH HAYASAKI, YUKINO UEDA, MASAYA ITO, MOTOKI TAKENAKA, TOMOYASU KUMANO, MINAKO MORI, MOEKA YASUE, HIROKO KATO-HAYASHI, RYO KOBAYASHI, KEN-ICHIROU MORISHIGE, MASAYUKI MATSUO, HIDEKI HAYASHI and AKIO SUZUKI

  Anticancer Research June 2022, 42 (6) 3117-3123; DOI: https://doi.org/10.21873/anticanres.15800
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  Difference in the Overall Survival Between Malignant Central Airway Obstruction Patients Treated by Transbronchial Microwave Ablation and Stent Placement: A Single-institution Retrospective Study

  KOSUKE KASHIWABARA, SHINJI FUJII, SHINSUKE TSUMURA and KAZUHIKO SAKAMOTO

  Anticancer Research June 2022, 42 (6) 3125-3131; DOI: https://doi.org/10.21873/anticanres.15801
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  Prognostic Impact of Relative Dose Intensity of Adjuvant Chemotherapy With S-1 on Pancreatic Ductal Adenocarcinoma

  HAJIME MATSUSHIMA, TOMOHIKO ADACHI, MASAAKI HIDAKA, MAMPEI YAMASHITA, TAKASHI HAMADA, SAEKO FUKUI, TAKAYUKI TANAKA, HAJIME IMAMURA, KYOHEI YOSHINO, TOTA KUGIYAMA, AMANE KITASATO, TAKANOBU HARA, AKIHIKO SOYAMA, KAZUMA KOBAYASHI, YORIHISA SUMIDA, TAMOTSU KUROKI and SUSUMU EGUCHI

  Anticancer Research June 2022, 42 (6) 3133-3141; DOI: https://doi.org/10.21873/anticanres.15802
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  Compartment-specific Clinical Outcomes in Patients With Soft Tissue Sarcomas of the Thigh

  SEI MORINAGA, AKIHIKO TAKEUCHI, NORIO YAMAMOTO, KATSUHIRO HAYASHI, SHINJI MIWA, KENTARO IGARASHI, HIROTAKA YONEZAWA, YOHEI ASANO, SHIRO SAITO, TAKAYUKI NOJIMA and HIROYUKI TSUCHIYA

  Anticancer Research June 2022, 42 (6) 3143-3150; DOI: https://doi.org/10.21873/anticanres.15803
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  Efficacy of Cabozantinib for Papillary Compared With Clear-cell Renal Cell Carcinoma Following Immune Checkpoint Inhibitor Treatment

  HIDEKAZU TACHIBANA, TORU INAKAWA, YUKI NEMOTO, HIROKI ISHIHARA, HIRONORI FUKUDA, KAZUHIKO YOSHIDA, JUNPEI IIZUKA, YASUNOBU HASHIMOTO, KAZUNARI TANABE, TSUNENORI KONDO and TOSHIO TAKAGI

  Anticancer Research June 2022, 42 (6) 3151-3158; DOI: https://doi.org/10.21873/anticanres.15804
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  Effect of Postoperative Muscle Loss After Resection of Non-small Cell Lung Cancer on Surgical Outcomes

  RYOTA NAKAMURA, SATOSHI YONEYAMA, RIKA TOBITA, SHUSUKE KURIHARA, TAKASHI HATORI, TAKESHI NUMATA, KYOKO OTA, HIDETOSHI YANAI, TAKEO ENDO, YUKINORI INADOME, HIROAKI SATOH and YOSHIHISA INAGE

  Anticancer Research June 2022, 42 (6) 3159-3168; DOI: https://doi.org/10.21873/anticanres.15805
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  The Prognostic Relevance of Preoperative CEA and CA19-9 for Ampulla of Vater Carcinoma

  SATOSHI MATSUI, YUSUKE YAMAMOTO, YUKIYASU OKAMURA, TAKAAKI ITO, RYO ASHIDA, KATSUHISA OHGI, MIHOKO YAMADA, SHIMPEI OTSUKA, KATSUHIKO UESAKA and TEIICHI SUGIURA

  Anticancer Research June 2022, 42 (6) 3169-3176; DOI: https://doi.org/10.21873/anticanres.15806
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  Preoperative S-1 Therapy for Head and Neck Carcinoma During the Waiting Period Before Surgery

  TAKASHI MATSUKI, CHIHIRO FUSHIMI, SHUNSUKE MIYAMOTO, HIDEAKI TAKAHASHI, TATSUO MASUBUCHI, YUICHIRO TADA, KOUKI MIURA, SHIN-ETSU KAMATA, KOICHI KANO, SHOHEI TSUTSUMI, KAHO MOMIYAMA and TAKU YAMASHITA

  Anticancer Research June 2022, 42 (6) 3177-3183; DOI: https://doi.org/10.21873/anticanres.15807
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  Suitability of Oral Rehydration Solution (ORS) for Use in the Cisplatin Short Hydration Method

  YOSHITAKA SAITO, YOH TAKEKUMA, MASAKI KOBAYASHI, NAOFUMI SHINAGAWA, TAKURO NOGUCHI, SATOSHI TAKEUCHI, YASUSHI SHIMIZU, ICHIRO KINOSHITA, HIROTOSHI DOSAKA-AKITA and MITSURU SUGAWARA

  Anticancer Research June 2022, 42 (6) 3185-3193; DOI: https://doi.org/10.21873/anticanres.15808
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  Adjuvant Concurrent Chemoradiotherapy Versus Adjuvant Chemotherapy Only in Locally Advanced Non-small-cell Lung Cancer With Involved Microscopic Resection Margin: A Population-based Cohort Study

  CHIH-YEN TU, HUNG-JEN CHEN, TE-CHUN HSIA, HSIN-YUAN FANG, CHIA-CHIN LI and CHUN-RU CHIEN

  Anticancer Research June 2022, 42 (6) 3195-3201; DOI: https://doi.org/10.21873/anticanres.15809
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  Contralateral Interhemispheric Transfalcine Approach for Supratentorial Extraventricular Ependymoma Resection

  MATIAS BALDONCINI, GIANLUCA FERINI, GIUSEPPE E. UMANA, BIPIN CHAURASIA, MICKAELA ECHAVARRIA DEMICHELIS, JUAN F. VILLALONGA, PAOLO PALMISCIANO, PAOLO AMICO, SABINO LUZZI, DEREK O. PIPOLO and ALVARO CAMPERO

  Anticancer Research June 2022, 42 (6) 3203-3207; DOI: https://doi.org/10.21873/anticanres.15810
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  Successful Treatment of Intrahepatic Cholangiocarcinoma With Liver/Lung Metastasis and Peritoneal Dissemination After Liver Resection

  KAZUKI MATSUMURA, KENSUKE YAMAMURA, ERI ODA, SHINICHI AKAHOSHI, TAKATOSHI ISHIKO, TATSUNORI MIYATA, HIDEAKI MIYAMOTO, TOSHIHIKO MOTOHARA, AKIRA SASAO, YOSHIHIRO KOMOHARA, HIDECHIKA KAWANO and TORU BEPPU

  Anticancer Research June 2022, 42 (6) 3209-3215; DOI: https://doi.org/10.21873/anticanres.15811
• Open Access

  Republication: Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours

  DANIELLE BOLLER, KATHRIN T. DOEPFNER, ANGELA DE LAURENTIIS, ANA S. GUERREIRO, MARIN MARINOV, TAREK SHALABY, PAUL DEPLEDGE, ANTHONY ROBSON, NAHID SAGHIR, MASAHIKO HAYAKAWA, HIROYUKI KAIZAWA, TOMONOBU KOIZUMI, TAKAHIDE OHISHI, SARAH FATTET, OLIVIER DELATTRE, ANELIA SCHWERI-OLAC, KATRIN HÖLAND, MICHAEL A. GROTZER, KARL FREI, OLIVIER SPERTINI, MICHAEL D. WATERFIELD and ALEXANDRE ARCARO

  Anticancer Research June 2022, 42 (6) 3217-3230; DOI: https://doi.org/10.21873/anticanres.15812