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Research ArticleExperimental Studies

The Prognostic Significance of p16 and its Role as a Surrogate Marker for Human Papilloma Virus in Oral Squamous Cell Carcinoma: An Analysis of 281 Cases

CHRISTIAN DOLL, CLAUDIUS STEFFEN, BENEDICTA BECK-BROICHSITTER, MAXIMILIAN RICHTER, KONRAD NEUMANN, ANNE POHRT, PHILIPP LOHNEIS, ANNIKA LEHMANN, MAX HEILAND, CARMEN STROMBERGER, ANNEKATRIN COORDES, KORINNA JOHRENS and JAN-DIRK RAGUSE
Anticancer Research May 2022, 42 (5) 2405-2413; DOI: https://doi.org/10.21873/anticanres.15719
CHRISTIAN DOLL
1Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Oral and Maxillofacial Surgery, Berlin, Germany;
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  • For correspondence: Christian.Doll@charite.de
CLAUDIUS STEFFEN
1Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Oral and Maxillofacial Surgery, Berlin, Germany;
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BENEDICTA BECK-BROICHSITTER
1Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Oral and Maxillofacial Surgery, Berlin, Germany;
2Katharinenhospital Stuttgart, Department of Oral and Maxillofacial Surgery, Stuttgart, Germany;
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MAXIMILIAN RICHTER
1Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Oral and Maxillofacial Surgery, Berlin, Germany;
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KONRAD NEUMANN
3Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Biometry and Clinical Epidemiology, Berlin, Germany;
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ANNE POHRT
3Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Biometry and Clinical Epidemiology, Berlin, Germany;
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PHILIPP LOHNEIS
4Institute of Pathology, University of Cologne, Cologne, Germany;
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ANNIKA LEHMANN
5Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pathology, Berlin, Germany;
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MAX HEILAND
1Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Oral and Maxillofacial Surgery, Berlin, Germany;
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CARMEN STROMBERGER
6Vivantes Klinikum Neukölln, Department of Radiooncology and Radiotherapy, Berlin, Germany;
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ANNEKATRIN COORDES
7Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Otorhinolaryngology, Berlin, Germany;
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KORINNA JOHRENS
8Institute of Pathology, Technische Universität Dresden, Dresden, Germany;
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JAN-DIRK RAGUSE
9Department of Oral and Maxillofacial Surgery, Fachklinik Hornheide, Münster, Germany
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    Figure 1.

    Immunohistochemical staining images of p16 in oral squamous cell carcinoma (OSCC). A) Weak cytoplasmic staining, the nuclei of the tumor cells are negative (black arrow); B) Strong nuclear staining (Table III, patient no. 2/HPV DNA PCR positive); C) Strong nuclear staining (Table III, patient no. 9 / HPV DNA PCR negative).

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    Figure 2.

    Kaplan–Meier curve showing overall survival of patients in relation to p16 expression ≥70% compared to <70%.

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    Figure 3.

    Kaplan–Meier curves showing overall survival of patients who received primary surgery and adjuvant radio(chemo)therapy in relation to p16 expression greater than 25% compared to ≤25%.

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Anticancer Research: 42 (5)
Anticancer Research
Vol. 42, Issue 5
May 2022
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The Prognostic Significance of p16 and its Role as a Surrogate Marker for Human Papilloma Virus in Oral Squamous Cell Carcinoma: An Analysis of 281 Cases
CHRISTIAN DOLL, CLAUDIUS STEFFEN, BENEDICTA BECK-BROICHSITTER, MAXIMILIAN RICHTER, KONRAD NEUMANN, ANNE POHRT, PHILIPP LOHNEIS, ANNIKA LEHMANN, MAX HEILAND, CARMEN STROMBERGER, ANNEKATRIN COORDES, KORINNA JOHRENS, JAN-DIRK RAGUSE
Anticancer Research May 2022, 42 (5) 2405-2413; DOI: 10.21873/anticanres.15719

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The Prognostic Significance of p16 and its Role as a Surrogate Marker for Human Papilloma Virus in Oral Squamous Cell Carcinoma: An Analysis of 281 Cases
CHRISTIAN DOLL, CLAUDIUS STEFFEN, BENEDICTA BECK-BROICHSITTER, MAXIMILIAN RICHTER, KONRAD NEUMANN, ANNE POHRT, PHILIPP LOHNEIS, ANNIKA LEHMANN, MAX HEILAND, CARMEN STROMBERGER, ANNEKATRIN COORDES, KORINNA JOHRENS, JAN-DIRK RAGUSE
Anticancer Research May 2022, 42 (5) 2405-2413; DOI: 10.21873/anticanres.15719
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Keywords

  • oral squamous cell carcinoma
  • prognostic factors
  • p16
  • HPV
  • adjuvant therapy
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