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Research ArticleExperimental Studies
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Pathological Significance and Prognostic Role of WWC1 in Upper Urinary Tract Urothelial Cancer

HIROKI KURATA, KENSUKE MITSUNARI, TSUBASA KONDO, MASAHITO MASATO, HIDENORI ITO, YUTA MUKAE, YUICHIRO NAKAMURA, TOMOHIRO MATSUO, KOJIRO OHBA, YASUSHI MOCHIZUKI, HIDEKI SAKAI and YASUYOSHI MIYATA
Anticancer Research May 2022, 42 (5) 2311-2317; DOI: https://doi.org/10.21873/anticanres.15710
HIROKI KURATA
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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KENSUKE MITSUNARI
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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  • For correspondence: kmitsunari@nagasaki-u.ac.jp
TSUBASA KONDO
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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MASAHITO MASATO
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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HIDENORI ITO
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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YUTA MUKAE
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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YUICHIRO NAKAMURA
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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TOMOHIRO MATSUO
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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KOJIRO OHBA
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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YASUSHI MOCHIZUKI
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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HIDEKI SAKAI
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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YASUYOSHI MIYATA
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
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    Figure 1.

    A representative example of WW and C2 domain-containing 1 (WWC1) immunostaining in normal urothelium (A), upper urinary tract urothelial cancer tissue judged as negative (B) and as positive (C) (magnification ×200).

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    Figure 2.

    The Kaplan–Meier survival curves according to WW and C2 domain-containing 1 (WWC1) expression for urinary tract cancer recurrence (A) and subsequent metastasis (B) after radical surgery.

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Anticancer Research: 42 (5)
Anticancer Research
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May 2022
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Pathological Significance and Prognostic Role of WWC1 in Upper Urinary Tract Urothelial Cancer
HIROKI KURATA, KENSUKE MITSUNARI, TSUBASA KONDO, MASAHITO MASATO, HIDENORI ITO, YUTA MUKAE, YUICHIRO NAKAMURA, TOMOHIRO MATSUO, KOJIRO OHBA, YASUSHI MOCHIZUKI, HIDEKI SAKAI, YASUYOSHI MIYATA
Anticancer Research May 2022, 42 (5) 2311-2317; DOI: 10.21873/anticanres.15710

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Pathological Significance and Prognostic Role of WWC1 in Upper Urinary Tract Urothelial Cancer
HIROKI KURATA, KENSUKE MITSUNARI, TSUBASA KONDO, MASAHITO MASATO, HIDENORI ITO, YUTA MUKAE, YUICHIRO NAKAMURA, TOMOHIRO MATSUO, KOJIRO OHBA, YASUSHI MOCHIZUKI, HIDEKI SAKAI, YASUYOSHI MIYATA
Anticancer Research May 2022, 42 (5) 2311-2317; DOI: 10.21873/anticanres.15710
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Keywords

  • WWC1
  • KIBRA
  • tumor growth
  • matrix metalloproteinases
  • predictive marker
  • upper urinary tract cancer
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