Table of Contents

Clinical Studies

• Open Access

  Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis – A Prospective Three-year Study

  SUVI SIRKKU TUOHINEN, TANJA SKYTTA, HEINI HUHTALA, VESA VIRTANEN, PIRKKO-LIISA KELLOKUMPU-LEHTINEN and PEKKA RAATIKAINEN

  Anticancer Research May 2022, 42 (5) 2507-2517; DOI: https://doi.org/10.21873/anticanres.15729
• Open Access

  A Higher Mean Heart Radiation Dose Induces Higher Frequency of Multiple Cardiac Changes

  SUVI SIRKKU TUOHINEN, HANNA AULA, TANJA SKYTTÄ, HEINI HUHTALA, KONSTA KESKI-PUKKILA, KJELL NIKUS, VESA VIRTANEN, PIRKKO-LIISA KELLOKUMPU-LEHTINEN and PEKKA RAATIKAINEN

  Anticancer Research May 2022, 42 (5) 2519-2529; DOI: https://doi.org/10.21873/anticanres.15730
• Open Access

  Poorly Differentiated Thyroid Carcinoma: Single Institution Series of Outcomes

  SIDDHARTH KUNTE, JONATHAN SHARETT, WEI WEI, CHRISTIAN NASR, BRANDON PRENDES, ERIC LAMARRE, JAMIE KU, ROBERT R. LORENZ, JOSEPH SCHARPF, BRIAN B. BURKEY, AKEESHA SHAH, NIKHIL JOSHI and JESSICA L. GEIGER

  Anticancer Research May 2022, 42 (5) 2531-2539; DOI: https://doi.org/10.21873/anticanres.15731
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  Prognostic Value of Peritoneal Cancer Index After Complete Cytoreductive Surgery in Advanced Ovarian Cancer

  MIHAELA ASP, SUSANNE MALANDER, JOHAN BENGTSSON, HANNA SARTOR and PAIVI KANNISTO

  Anticancer Research May 2022, 42 (5) 2541-2551; DOI: https://doi.org/10.21873/anticanres.15732
• Open Access

  Acute Side-effects of Different Radiotherapy Treatment Schedules in Early Prostate Cancer

  PETRI REINIKAINEN, MIKA KAPANEN, TIINA LUUKKAALA and PIRKKO-LIISA KELLOKUMPU-LEHTINEN

  Anticancer Research May 2022, 42 (5) 2553-2565; DOI: https://doi.org/10.21873/anticanres.15733
• Open Access

  Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease

  YUTARO KUBOTA, QINGHONG HAN, CHIHIRO HOZUMI, NORIYUKI MASAKI, JUN YAMAMOTO, YUSUKE AOKI, TAKUYA TSUNODA and ROBERT M. HOFFMAN

  Anticancer Research May 2022, 42 (5) 2567-2572; DOI: https://doi.org/10.21873/anticanres.15734
• Open Access

  Surgical Indications for Huge Hepatocellular Carcinoma

  TAKAFUMI KUMAMOTO, RYUSEI MATSUYAMA, KAZUHISA TAKEDA, YU SAWADA, KOTA SAHARA, DAISUKE MORIOKA, SHAO-CIAO LUO, YASUHIRO YABUSHITA, YUKI HOMMA and ITARU ENDO

  Anticancer Research May 2022, 42 (5) 2573-2581; DOI: https://doi.org/10.21873/anticanres.15735
• Open Access

  Prognostic Implication of PD-L1 Expression on Osimertinib Treatment for EGFR-mutated Non-small Cell Lung Cancer

  TOSHIHIRO SHIOZAWA, TAKESHI NUMATA, TOMOHIRO TAMURA, TAKEO ENDO, TAKAYUKI KABURAGI, YUSUKE YAMAMOTO, HIDEYASU YAMADA, NORIHIRO KIKUCHI, KAZUHITO SAITO, MASAHARU INAGAKI, KOICHI KURISHIMA, YASUNORI FUNAYAMA, KUNIHIKO MIYAZAKI, NOBUYUKI KOYAMA, KINYA FURUKAWA, HIROYUKI NAKAMURA, SHINJI KIKUCHI, HIDEO ICHIMURA, YUKIO SATO, IKUO SEKINE, HIROAKI SATOH and NOBUYUKI HIZAWA

  Anticancer Research May 2022, 42 (5) 2583-2590; DOI: https://doi.org/10.21873/anticanres.15736
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  Proton Pump Inhibitors Ameliorate Capecitabine-induced Hand-Foot Syndrome in Patients With Breast Cancer: A Retrospective Study

  MIHO TAKEMURA, KENJI IKEMURA, TETSUHIRO YOSHINAMI, YUJI TOYOZUMI, TAKUYA SHINTANI, MIKIKO UEDA, KENZO SHIMAZU and MASAHIRO OKUDA

  Anticancer Research May 2022, 42 (5) 2591-2598; DOI: https://doi.org/10.21873/anticanres.15737
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  p16/Ki-67 Dual Staining Is a Reliable Biomarker for Risk Stratification for Patients With Borderline/Mild Cytology in Cervical Cancer Screening

  MARIA MAGKANA, PANAGIOTA MENTZELOPOULOU, EKATERINI MAGKANA, ANDREAS PAMPANOS, NIKOLAOS VRACHNIS, ELENI KALAFATI, GEORGIOS DASKALAKIS, EKATERINI DOMALI, NIKOLAOS THOMAKOS, ALEXANDROS RODOLAKIS, NICHOLAS P. ANAGNOU and KALLIOPI I. PAPPA

  Anticancer Research May 2022, 42 (5) 2599-2606; DOI: https://doi.org/10.21873/anticanres.15738
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  Posterior-Anterior Cephalometric Study of Neurofibromatosis Type 1 Patients With Facial Plexiform Neurofibroma: Analysis of Skeletal Symmetry Concerning Midfacial and Skull Base Reference Points (Zygomatic Arch, Mastoid, and Juga)

  REINHARD E. FRIEDRICH, GEORG CHRIST and HANNA A. SCHEUER

  Anticancer Research May 2022, 42 (5) 2607-2623; DOI: https://doi.org/10.21873/anticanres.15739
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  Chemotherapy-induced Reversion of Mutant RAS to Wild-type RAS in Metastatic Colorectal Cancer

  SUMITO SATO, YO MIKAYAMA, MANABU SHIOZAWA, SUGURU NUKADA, KENTA IGUCHI, HIRONAO OKAMOTO, TAKASHI KOHMURA, KEISUKE KAZAMA, KUNIYA TANAKA, TAKASHI OSHIMA and YASUSHI RINO

  Anticancer Research May 2022, 42 (5) 2625-2635; DOI: https://doi.org/10.21873/anticanres.15740
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  Bevacizumab-based Salvage Chemotherapy Improves Survival Outcomes for Patients With Brain Metastasis from Ovarian Cancer

  SHINICHI TATE, KYOKO NISHIKIMI, AYUMU MATSUOKA, SATOYO OTSUKA and MAKIO SHOZU

  Anticancer Research May 2022, 42 (5) 2637-2644; DOI: https://doi.org/10.21873/anticanres.15741
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  Impact of Histological Features on Adjuvant Chemotherapy for Invasive Intraductal Papillary Mucinous Carcinoma

  TAKAAKI FURUKAWA, MANABU TAKAMATSU, YOSUKE INOUE, TAKESHI OKAMOTO, TAKAFUMI MIE, YUTO YAMADA, TSUYOSHI TAKEDA, AKIYOSHI KASUGA, MASATO MATSUYAMA, TAKASHI SASAKI, MASATO OZAKA, ATSUSHI OBA, HIROMICHI ITO, YOSHIHIRO ONO, TAKAFUMI SATO, YU TAKAHASHI, AKIO SAIURA and NAOKI SASAHIRA

  Anticancer Research May 2022, 42 (5) 2645-2655; DOI: https://doi.org/10.21873/anticanres.15742
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  Risk Factors for Xerostomia Following Radiotherapy of Head-and-Neck Cancers

  BRITTA WARWAS, FLORIAN CREMERS, KARSTEN GERULL, ANKE LEICHTLE, KARL L. BRUCHHAGE, SAMER G. HAKIM, STEVEN E. SCHILD and DIRK RADES

  Anticancer Research May 2022, 42 (5) 2657-2663; DOI: https://doi.org/10.21873/anticanres.15743
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  Early Metabolic Changes in 1H-MRSI Predictive for Survival in Patients With Newly Diagnosed High-grade Glioma

  MICHAEL H. WANG, WILSON ROA, KEITH WACHOWICZ, ATIYAH YAHYA, ALBERT MURTHA, JOHN AMANIE, JONATHAN CHAINEY, HARVEY QUON, SUNITA GHOSH and SAMIR PATEL

  Anticancer Research May 2022, 42 (5) 2665-2673; DOI: https://doi.org/10.21873/anticanres.15744
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  Phase II Study of S-1 and Irinotecan Plus Bevacizumab as Second-line Treatment for Patients With Metastatic Colorectal Cancer Resistant to the Fluoropyrimidine-oxaliplatin-cetuximab Regimen

  HIROAKI TANIOKA, KEN SHIMADA, AKIHITO TSUJI, MITSUGU KOCHI, HO MIN KIM, TAKAO TAKAHASHI, TADAMICHI DENDA, AKINORI TAKAGANE, TAKANORI WATANABE, MASAHITO KOTAKA, MASATO NAKAMURA, YU SUNAKAWA, MASAHIRO TAKEUCHI, WATARU ICHIKAWA and MASASHI FUJII

  Anticancer Research May 2022, 42 (5) 2675-2681; DOI: https://doi.org/10.21873/anticanres.15745
• Open Access

  Initial Safety Analysis of CapeOx for Elderly Patients With Advanced Gastric Cancer Patients: A Phase II Trial

  KEISHO CHIN, DAISUKE TAKAHARI, RYOHEI KAWABATA, HISASHI HOSAKA, SO SAITOU, TAKESHI SHIRAISHI, HIROSHI YABUSAKI, MASAHIRO GOTO, MASATO NAKAMURA, HIROSHI IMAMURA, YOSHIAKI SHINDO, FUMIO NAGASHIMA, WATARU ICHIKAWA, TAKASHI SAOTOME, WATARU YAMAMOTO, NAOKI ISHIZUKA and KENSEI YAMAGUCHI

  Anticancer Research May 2022, 42 (5) 2683-2687; DOI: https://doi.org/10.21873/anticanres.15746
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  Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma

  WASSAPOL WONGPANUWICH, SOMCHAI YODSANGA, RISA CHAISUPARAT and PANOMWAT AMORNPHIMOLTHAM

  Anticancer Research May 2022, 42 (5) 2689-2699; DOI: https://doi.org/10.21873/anticanres.15747
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  Repeated Stereotactic Body Radiotherapy for Lung Malignancies: Toxicity Can Be Reduced by Sparing Lung Irradiation

  SHOU WATANABE, HIDEYA YAMAZAKI, TAKYUA KIMOTO, GEN SUZUKI and KEI YAMADA

  Anticancer Research May 2022, 42 (5) 2701-2709; DOI: https://doi.org/10.21873/anticanres.15748
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  The Systemic Inflammation Score Is an Independent Prognostic Factor for Esophageal Cancer Patients who Receive Curative Treatment

  TORU AOYAMA, MIHWA JU, KEISUKE KOMORI, HIROSHI TAMAGAWA, AYAKO TAMAGAWA, YUKIO MAEZAWA, ITARU HASHIMOTO, KAZUKI KANO, KENTARO HARA, HARUHIKO CHO, KENKI SEGAMI, DAISUKE MACHIDA, MASATO NAKAZONO, TAKASHI OSHIMA, NORIO YUKAWA and YASUSHI RINO

  Anticancer Research May 2022, 42 (5) 2711-2717; DOI: https://doi.org/10.21873/anticanres.15749
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  Usefulness of Surgical Staging of Gastric Cancer in Neoadjuvant Chemotherapy Candidates: A Single-center Retrospective Study

  KEISUKE KOMORI, KAZUKI KANO, TAKANOBU YAMADA, HAYATO WATANABE, KOSUKE TAKAHASHI, YUKIO MAEZAWA, HIROHITO FUJIKAWA, MASAKATSU NUMATA, TORU AOYAMA, HIROSHI TAMAGAWA, NORIO YUKAWA, YASUSHI RINO, MUNETAKA MASUDA, TAKASHI OGATA and TAKASHI OSHIMA

  Anticancer Research May 2022, 42 (5) 2719-2725; DOI: https://doi.org/10.21873/anticanres.15750
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  Impact of Cytoreductive Nephrectomy Following Nivolumab Plus Ipilimumab Therapy for Patients With Advanced Renal Cell Carcinoma

  SUGURU SHIROTAKE, YU MIYAMA, YASUTAKA BABA, HIROYUKI TAJIMA, YOSHITAKA OKADA, KEN NAKAZAWA, YOKO USAMI, MASANORI YASUDA, DAISUKE IGARASHI, GO KANEKO, KENT KANAO, MASAFUMI OYAMA and KOSHIRO NISHIMOTO

  Anticancer Research May 2022, 42 (5) 2727-2735; DOI: https://doi.org/10.21873/anticanres.15751
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  Time to Onset of Bendamustine-associated Skin Damage Using the Spontaneous Reporting System

  MISUI KASHIWAGI, TADASHI SHIMIZU, RIKA KAWAI, TAKEHIRO KAWASHIRI, YOSHIHIRO UESAWA and MAYAKO UCHIDA

  Anticancer Research May 2022, 42 (5) 2737-2741; DOI: https://doi.org/10.21873/anticanres.15752
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  Diversified Effects of Bile Contamination, Postoperative Infections, and Antimicrobial Resistance Level on the Oncologic Prognosis After Pancreatoduodenectomy for Ductal Adenocarcinoma

  LUCA GIANOTTI, KIM C. HONSELMANN, MARCO ANGRISANI, FRANCESCA GAVAZZI, TOBIAS KECK, ULRICH WELLNER, LOUISA BOLM, NATALIE PETRUCH, GIOVANNI CAPRETTI, GENNARO NAPPO, DAVIDE P. BERNASCONI, MARTA SANDINI and ALESSANDRO ZERBI

  Anticancer Research May 2022, 42 (5) 2743-2752; DOI: https://doi.org/10.21873/anticanres.15753
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  High Receptor-interacting Serine/Threonine-protein Kinase 3 (RIP3) Expression Serves as an Independent Poor Prognostic Factor for Triple-negative Breast Carcinoma

  YUMIN CHUNG, SINAE KIM, HYUN-SOO KIM and SUNG-IM DO

  Anticancer Research May 2022, 42 (5) 2753-2761; DOI: https://doi.org/10.21873/anticanres.15754
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  Impact of Infectious Complications on Survival and Recurrence of Patients With Stage II/III Colorectal Cancer: A Multicenter Retrospective Study

  HIROSHI TAMAGAWA, TORU AOYAMA, MASAKATSU NUMATA, KEISUKE KAZAMA, YOSUKE ATSUMI, KENTA IGUCHI, MIHWA JU, SHO SAWAZAKI, SUMITO SATO, KAZUKI KANO, TAKASHI OHSHIMA, TAKANOBU YAMADA, TENI GODAI, AKIO HIGUCHI, HIROYUKI SAEKI, NORIO YUKAWA and YASUSHI RINO

  Anticancer Research May 2022, 42 (5) 2763-2769; DOI: https://doi.org/10.21873/anticanres.15755
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  Handgrip Strength Predicts Poorly the Surgical Outcome or Length of Hospitalization in Patients With Surgically Operated Oral Cancer

  JUHO SUOJANEN, SATU KAINULAINEN, LAURA TARVAINEN, JYRKI TORNWALL and TOMMY WILKMAN

  Anticancer Research May 2022, 42 (5) 2771-2774; DOI: https://doi.org/10.21873/anticanres.15756
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  Impact of the Platelet-to-Lymphocyte Ratio as a Biomarker for Esophageal Squamous Cell Carcinoma

  TAKASHI KATO, TARO OSHIKIRI, HIRONOBU GOTO, RYUICHIRO SAWADA, HITOSHI HARADA, NAOKI URAKAWA, HIROSHI HASEGAWA, SHINGO KANAJI, KIMIHIRO YAMASHITA, TAKERU MATSUDA and YOSHIHIRO KAKEJI

  Anticancer Research May 2022, 42 (5) 2775-2782; DOI: https://doi.org/10.21873/anticanres.15757
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  Usefulness of Prophylactic Administration of Pegfilgrastim for Esophageal Cancer Chemotherapy: A Single-center Retrospective Study

  KOICHI OKAMOTO, ITASU NINOMIYA, HIROTO SAITO, MARI SHIMADA, TAKAHISA YAMAGUCHI, SHIRO TERAI, HIDEKI MORIYAMA, JUN KINOSHITA, KEISHI NAKAMURA and NORIYUKI INAKI

  Anticancer Research May 2022, 42 (5) 2783-2790; DOI: https://doi.org/10.21873/anticanres.15758
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  Clinical Outcomes of Esophagectomy and Chemoradiotherapy After Endoscopic Resection for Superficial Esophageal Squamous Cell Carcinoma

  MANABU EMI, YOICHI HMAI, TORU YOSHIKAWA, RYOSUKE HIROHATA, MANATO OSAWA, MORIHITO OKADA, YUJI MURAKAMI and IKUNO NISHIBUCHI

  Anticancer Research May 2022, 42 (5) 2791-2795; DOI: https://doi.org/10.21873/anticanres.15759
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  Prognostic Value of the Regional Lymph Node Station in Pancreatic Neuroendocrine Tumor

  KOSEI TAKAGI, YUZO UMEDA, RYUICHI YOSHIDA, KAZUHIRO YOSHIDA, TOMOKAZU FUJI, KENJIRO KUMANO, KAZUYA YASUI, TAKAHITO YAGI and TOSHIYOSHI FUJIWARA

  Anticancer Research May 2022, 42 (5) 2797-2801; DOI: https://doi.org/10.21873/anticanres.15760