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Research ArticleClinical Studies
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Cisplatin Plus Capecitabine After Adjuvant S-1 in Metastatic Gastric Cancer: A Phase II T-CORE1102 Trial

TAKASHI YOSHIOKA, MASANOBU TAKAHASHI, YASUHIRO SAKAMOTO, AKIRA OKITA, TADAHISA FUKUI, YASUKO MURAKAWA, YOSHIAKI SHINDO, HIROO IMAI, HISATSUGU OHORI, HIDEKAZU SHIROTA, NATSUKO CHIBA, YURIKO (ITO) SASAHARA, TAKASHI NOMURA, NORIMASA FUKUSHIMA, TAKUHIRO YAMAGUCHI, HIDEKI SHIMODAIRA and CHIKASHI ISHIOKA
Anticancer Research April 2022, 42 (4) 2009-2015; DOI: https://doi.org/10.21873/anticanres.15680
TAKASHI YOSHIOKA
1Department of Clinical Oncology, Yamagata University School of Medicine, Yamagata, Japan;
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MASANOBU TAKAHASHI
2Department of Medical Oncology, Tohoku University Hospital, Sendai, Japan;
3Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;
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YASUHIRO SAKAMOTO
4Department of Medical Oncology, Osaki Citizen Hospital, Osaki, Japan;
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AKIRA OKITA
4Department of Medical Oncology, Osaki Citizen Hospital, Osaki, Japan;
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TADAHISA FUKUI
1Department of Clinical Oncology, Yamagata University School of Medicine, Yamagata, Japan;
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YASUKO MURAKAWA
5Department of Medical Oncology, Miyagi Cancer Center, Medeshima, Japan;
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YOSHIAKI SHINDO
6Department of Gastroenterological Surgery, Nakadori General Hospital, Akita, Japan;
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HIROO IMAI
7Department of Clinical Oncology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan;
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HISATSUGU OHORI
7Department of Clinical Oncology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan;
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HIDEKAZU SHIROTA
1Department of Clinical Oncology, Yamagata University School of Medicine, Yamagata, Japan;
2Department of Medical Oncology, Tohoku University Hospital, Sendai, Japan;
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NATSUKO CHIBA
1Department of Clinical Oncology, Yamagata University School of Medicine, Yamagata, Japan;
8Department of Cancer Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;
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YURIKO (ITO) SASAHARA
9Department of Medical Oncology, Yamagata Prefectural Central Hospital, Yamagata, Japan;
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TAKASHI NOMURA
10Department of Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan;
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NORIMASA FUKUSHIMA
10Department of Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan;
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TAKUHIRO YAMAGUCHI
11Division of Biostatistics, Tohoku University Graduate School of Medicine, Sendai, Japan;
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HIDEKI SHIMODAIRA
1Department of Clinical Oncology, Yamagata University School of Medicine, Yamagata, Japan;
2Department of Medical Oncology, Tohoku University Hospital, Sendai, Japan;
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CHIKASHI ISHIOKA
2Department of Medical Oncology, Tohoku University Hospital, Sendai, Japan;
3Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan;
12Department of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan
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  • For correspondence: chikashi{at}tohoku.ac.jp
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    Figure 1.

    Progression-free survival, overall survival, and time to treatment failure of patients enrolled in this study. (A) Kaplan–Meier curve for progression-free survival among patients enrolled in this study. (B) Kaplan–Meier curve for overall survival among patients enrolled in this study. (C) Kaplan–Meier curve for time to treatment failure among patients enrolled in this study.

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    Figure 2.

    Progression-free survival and overall survival of patients with early recurrence within 6 months after the completion of S-1 adjuvant therapy and those with late recurrence more than 6 months or later after the completion of S-1 adjuvant therapy. (A) Kaplan–Meier curves for progression-free survival among patients with early recurrence within 6 months after the completion of S-1 adjuvant therapy and those with late recurrence more than 6 months or later after the completion of S-1 adjuvant therapy. (B) Kaplan–Meier curves for overall survival among patients with early recurrence within 6 months after completion of S-1 adjuvant therapy and those with late recurrence more than 6 months after the completion of S-1 adjuvant therapy.

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April 2022
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Cisplatin Plus Capecitabine After Adjuvant S-1 in Metastatic Gastric Cancer: A Phase II T-CORE1102 Trial
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Cisplatin Plus Capecitabine After Adjuvant S-1 in Metastatic Gastric Cancer: A Phase II T-CORE1102 Trial
TAKASHI YOSHIOKA, MASANOBU TAKAHASHI, YASUHIRO SAKAMOTO, AKIRA OKITA, TADAHISA FUKUI, YASUKO MURAKAWA, YOSHIAKI SHINDO, HIROO IMAI, HISATSUGU OHORI, HIDEKAZU SHIROTA, NATSUKO CHIBA, YURIKO (ITO) SASAHARA, TAKASHI NOMURA, NORIMASA FUKUSHIMA, TAKUHIRO YAMAGUCHI, HIDEKI SHIMODAIRA, CHIKASHI ISHIOKA
Anticancer Research Apr 2022, 42 (4) 2009-2015; DOI: 10.21873/anticanres.15680

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Cisplatin Plus Capecitabine After Adjuvant S-1 in Metastatic Gastric Cancer: A Phase II T-CORE1102 Trial
TAKASHI YOSHIOKA, MASANOBU TAKAHASHI, YASUHIRO SAKAMOTO, AKIRA OKITA, TADAHISA FUKUI, YASUKO MURAKAWA, YOSHIAKI SHINDO, HIROO IMAI, HISATSUGU OHORI, HIDEKAZU SHIROTA, NATSUKO CHIBA, YURIKO (ITO) SASAHARA, TAKASHI NOMURA, NORIMASA FUKUSHIMA, TAKUHIRO YAMAGUCHI, HIDEKI SHIMODAIRA, CHIKASHI ISHIOKA
Anticancer Research Apr 2022, 42 (4) 2009-2015; DOI: 10.21873/anticanres.15680
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Keywords

  • Cisplatin
  • Capecitabine
  • Gastric cancer
  • Adjuvant chemotherapy
  • metastasis
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