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Research ArticleClinical Studies

Differences in Patterns of Recurrence Between Primary and Interval Debulking Surgery for Advanced Ovarian Cancer

VASILEIOS MITSOPOULOS, ANNI INNAMAA, JONATHAN LIPPIATT, SARAH COLLINS and IOANNIS BILIATIS
Anticancer Research April 2022, 42 (4) 2003-2008; DOI: https://doi.org/10.21873/anticanres.15679
VASILEIOS MITSOPOULOS
1Gynaecological Oncology Department, University Hospitals Dorset, NHS Foundation Trust, Poole, U.K.;
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ANNI INNAMAA
1Gynaecological Oncology Department, University Hospitals Dorset, NHS Foundation Trust, Poole, U.K.;
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JONATHAN LIPPIATT
1Gynaecological Oncology Department, University Hospitals Dorset, NHS Foundation Trust, Poole, U.K.;
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SARAH COLLINS
2Salisbury Hospital, NHS Foundation Trust, Salisbury, U.K.
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IOANNIS BILIATIS
1Gynaecological Oncology Department, University Hospitals Dorset, NHS Foundation Trust, Poole, U.K.;
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  • For correspondence: Ioannis.Biliatis@uhd.nhs.uk giannisbil@hotmail.com
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Abstract

Background/Aim: This study aimed to identify differences in the pattern and timing of recurrence in patients with advanced ovarian cancer undergoing primary (PDS) or interval debulking surgery after neoadjuvant chemotherapy (NACT). Patients and Methods: Data were prospectively collected on 105 patients from June 2016 to March 2020. Results: There were 30 (50%) recurrences in the PDS group compared to 32 (72.7%) in the NACT group (p=0.020). An intra-abdominal relapse was more common in NACT compared to PDS patients (64.4% vs. 38.3%, p=0.008) and a recurrence in two or more sites (NACT: 44.4% vs. PDS: 23.3%, p=0.010). Among completely cytoreduced patients, a pelvic recurrence was more frequent in NACT patients (NACT: 50% vs. 22.4% in PDS, p=0.011). Progression-free survival (PFS) was longer in PDS compared to NACT (27 vs. 16 months, p=0.039). Conclusion: NACT patients experienced an unfavorable distribution and timing of recurrent disease compared to patient who underwent PDS.

Key Words:
  • Recurrence of ovarian cancer
  • primary debulking surgery
  • interval debulking surgery
  • progression-free survival
  • metastasis
  • Received January 13, 2022.
  • Revision received February 12, 2022.
  • Accepted February 14, 2022.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 42 (4)
Anticancer Research
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April 2022
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Differences in Patterns of Recurrence Between Primary and Interval Debulking Surgery for Advanced Ovarian Cancer
VASILEIOS MITSOPOULOS, ANNI INNAMAA, JONATHAN LIPPIATT, SARAH COLLINS, IOANNIS BILIATIS
Anticancer Research Apr 2022, 42 (4) 2003-2008; DOI: 10.21873/anticanres.15679

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Differences in Patterns of Recurrence Between Primary and Interval Debulking Surgery for Advanced Ovarian Cancer
VASILEIOS MITSOPOULOS, ANNI INNAMAA, JONATHAN LIPPIATT, SARAH COLLINS, IOANNIS BILIATIS
Anticancer Research Apr 2022, 42 (4) 2003-2008; DOI: 10.21873/anticanres.15679
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Keywords

  • Recurrence of ovarian cancer
  • primary debulking surgery
  • interval debulking surgery
  • progression-free survival
  • metastasis
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