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Research ArticleClinical Studies

Prognostic Impact of N2 of the Primary Tumour in Surgical Resection for Colorectal Liver Metastases

KOICHI TOMITA, NAOKAZU CHIBA, SHIGETO OCHIAI, TAKAHIRO GUNJI, TOSHIMICHI KOBAYASHI, TORU SANO, EIJI HIDAKA and SHIGEYUKI KAWACHI
Anticancer Research April 2022, 42 (4) 1997-2001; DOI: https://doi.org/10.21873/anticanres.15678
KOICHI TOMITA
Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan
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NAOKAZU CHIBA
Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan
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SHIGETO OCHIAI
Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan
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TAKAHIRO GUNJI
Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan
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TOSHIMICHI KOBAYASHI
Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan
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TORU SANO
Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan
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EIJI HIDAKA
Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan
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SHIGEYUKI KAWACHI
Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan
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  • For correspondence: skawachi@tokyo-med.ac.jp
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Abstract

Background/Aim: The status of lymph node metastasis of primary tumours remains to be completely investigated. This study investigated the prognostic impact of the degree of primary lymph node metastasis in patients with colorectal liver metastasis. Patients and Methods: We retrospectively analysed the clinical data of 106 patients with colorectal liver metastases who underwent surgical resection. Prognostic factors, including the degree of the positive primary lymph nodes, positive lymph node ratio, and log odds of positive lymph nodes, were evaluated. Results: The T factor and N2 status were independent risk factors for overall survival in patients who underwent surgical resection. Survival was significantly lower in the N2 group than in the N0-1 group. Additionally, ≥N2 status showed better prognostic performance than ≥N1 status. Conclusion: N2 of primary tumours is an independent useful prognostic factor in colorectal liver metastasis and can help determine the indication of surgical resection and pre/post-operative chemotherapy.

Key Words:
  • Colorectal liver metastasis
  • prognostic factor
  • lymph node metastasis
  • N factor
  • TNM classification
  • Received January 4, 2022.
  • Revision received February 4, 2022.
  • Accepted February 21, 2022.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Prognostic Impact of N2 of the Primary Tumour in Surgical Resection for Colorectal Liver Metastases
KOICHI TOMITA, NAOKAZU CHIBA, SHIGETO OCHIAI, TAKAHIRO GUNJI, TOSHIMICHI KOBAYASHI, TORU SANO, EIJI HIDAKA, SHIGEYUKI KAWACHI
Anticancer Research Apr 2022, 42 (4) 1997-2001; DOI: 10.21873/anticanres.15678

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Prognostic Impact of N2 of the Primary Tumour in Surgical Resection for Colorectal Liver Metastases
KOICHI TOMITA, NAOKAZU CHIBA, SHIGETO OCHIAI, TAKAHIRO GUNJI, TOSHIMICHI KOBAYASHI, TORU SANO, EIJI HIDAKA, SHIGEYUKI KAWACHI
Anticancer Research Apr 2022, 42 (4) 1997-2001; DOI: 10.21873/anticanres.15678
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Keywords

  • Colorectal liver metastasis
  • prognostic factor
  • lymph node metastasis
  • N factor
  • TNM classification
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