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Research ArticleClinical Studies

Baseline Modified Glasgow Prognostic Score (mGPS) Predicts Radiologic Response and Overall Survival in Metastatic Hormone-sensitive Prostate Cancer Treated With Docetaxel Chemotherapy

MANUEL NEUBERGER, JANINA SKLADNY, NORA GOLY, FREDERIK WESSELS, CHRISTEL WEIß, LUISA EGEN, PHILIPP ERBEN, MATTHIAS GROß-WEEGE, BRITTA GRÜNE, FRIEDRICH HARTUNG, JONAS HERRMANN, PATRICK HONECK, JONAS JARCZYK, KARL-FRIEDRICH KOWALEWSKI, JULIA MÜHLBAUER, KATJA NITSCHKE, MALIN NIENTIEDT, MARGARETE THERESA WALACH, FRANK WALDBILLIG, NIKLAS WESTHOFF, JOST VON HARDENBERG, MAXIMILIAN KRIEGMAIR, THOMAS S. WORST and PHILIPP NUHN
Anticancer Research April 2022, 42 (4) 1911-1918; DOI: https://doi.org/10.21873/anticanres.15668
MANUEL NEUBERGER
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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  • For correspondence: manuel.neuberger@medma.uni-heidelberg.de
JANINA SKLADNY
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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NORA GOLY
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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FREDERIK WESSELS
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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CHRISTEL WEIß
2Department of Medical Statistics and Biomathematics, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
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LUISA EGEN
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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PHILIPP ERBEN
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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MATTHIAS GROß-WEEGE
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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BRITTA GRÜNE
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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FRIEDRICH HARTUNG
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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JONAS HERRMANN
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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PATRICK HONECK
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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JONAS JARCZYK
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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KARL-FRIEDRICH KOWALEWSKI
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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JULIA MÜHLBAUER
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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KATJA NITSCHKE
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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MALIN NIENTIEDT
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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MARGARETE THERESA WALACH
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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FRANK WALDBILLIG
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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NIKLAS WESTHOFF
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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JOST VON HARDENBERG
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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MAXIMILIAN KRIEGMAIR
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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THOMAS S. WORST
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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PHILIPP NUHN
1Department of Urology and Urologic Surgery, University Medical Center Mannheim (UMM), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany;
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Abstract

Background/Aim: To assess the baseline inflammatory markers modified Glasgow Prognostic Score (mGPS), systemic immune-inflammation index (SII), and neutrophile-to-lymphocyte ratio (NLR) as pragmatic tools for predicting response to chemohormonal therapy (docetaxel plus ADT) and prognosis in men with metastatic hormone-sensitive prostate cancer (mHSPC). Patients and Methods: Male patients who received docetaxel at a tertiary university care center between 2014 and 2019 were screened for completion of 6 cycles. NLR, SII, mGPS, overall survival (OS), three-year survival, and radiologic response were assessed. Complete response (CR), partial response (PR), and stable disease (SD) were analyzed alone and in combination. Results: Thirty-six mHSPC-patients were included. In thirty patients, baseline mGPS was assessed and was either 0 (n=22) or 2 (n=8). In Cochran-Armitage Trend Test, mGPS showed significant association with the combined radiologic endpoint of “CR, PR, or SD” (p=0.01), three-year survival (p=0.02), and OS (p<0.01). Next to prostate-specific antigen (PSA) (HR per 100 units 1.16, 95%CI=1.04-1.30, p<0.01), NLR (HR=1.31, 95%CI=1.03-1.66, p=0.03), and mGPS (2 vs. 0, HR=6.53, 95%CI=1.6-27.0, p<0.01) at baseline showed significant association with OS in univariable cox regression. However, mGPS remained the only independent predictor for OS in multivariable cox regression (p<0.01) and for the combined radiologic endpoint of “CR, PR or SD” (p=0.01) in multivariable logistic regression. SII showed no statistical relevance. Conclusion: Baseline mGPS seems to be a pragmatic tool for clinical decision-making in patients with mHSPC in daily routine.

Key Words:
  • Biomarkers
  • prognosis
  • overall survival
  • systemic immune-inflammation index
  • neutrophile-to-lymphocyte ratio
  • Received February 18, 2022.
  • Revision received March 1, 2022.
  • Accepted March 3, 2022.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 42 (4)
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Baseline Modified Glasgow Prognostic Score (mGPS) Predicts Radiologic Response and Overall Survival in Metastatic Hormone-sensitive Prostate Cancer Treated With Docetaxel Chemotherapy
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Baseline Modified Glasgow Prognostic Score (mGPS) Predicts Radiologic Response and Overall Survival in Metastatic Hormone-sensitive Prostate Cancer Treated With Docetaxel Chemotherapy
MANUEL NEUBERGER, JANINA SKLADNY, NORA GOLY, FREDERIK WESSELS, CHRISTEL WEIß, LUISA EGEN, PHILIPP ERBEN, MATTHIAS GROß-WEEGE, BRITTA GRÜNE, FRIEDRICH HARTUNG, JONAS HERRMANN, PATRICK HONECK, JONAS JARCZYK, KARL-FRIEDRICH KOWALEWSKI, JULIA MÜHLBAUER, KATJA NITSCHKE, MALIN NIENTIEDT, MARGARETE THERESA WALACH, FRANK WALDBILLIG, NIKLAS WESTHOFF, JOST VON HARDENBERG, MAXIMILIAN KRIEGMAIR, THOMAS S. WORST, PHILIPP NUHN
Anticancer Research Apr 2022, 42 (4) 1911-1918; DOI: 10.21873/anticanres.15668

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Baseline Modified Glasgow Prognostic Score (mGPS) Predicts Radiologic Response and Overall Survival in Metastatic Hormone-sensitive Prostate Cancer Treated With Docetaxel Chemotherapy
MANUEL NEUBERGER, JANINA SKLADNY, NORA GOLY, FREDERIK WESSELS, CHRISTEL WEIß, LUISA EGEN, PHILIPP ERBEN, MATTHIAS GROß-WEEGE, BRITTA GRÜNE, FRIEDRICH HARTUNG, JONAS HERRMANN, PATRICK HONECK, JONAS JARCZYK, KARL-FRIEDRICH KOWALEWSKI, JULIA MÜHLBAUER, KATJA NITSCHKE, MALIN NIENTIEDT, MARGARETE THERESA WALACH, FRANK WALDBILLIG, NIKLAS WESTHOFF, JOST VON HARDENBERG, MAXIMILIAN KRIEGMAIR, THOMAS S. WORST, PHILIPP NUHN
Anticancer Research Apr 2022, 42 (4) 1911-1918; DOI: 10.21873/anticanres.15668
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Keywords

  • biomarkers
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  • systemic immune-inflammation index
  • neutrophile-to-lymphocyte ratio
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