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Research ArticleExperimental Studies

CJ14939, a Novel JAK Inhibitor, Increases Oxaliplatin-induced Cell Death Through JAK/STAT Pathway in Colorectal Cancer

JUN KI HONG, DO YEON KIM, JAE-SIK SHIN, YEA SEONG RYU, JAI-HEE MOON, DONG-IN KOH, SEUL LEE, JINWOO LEE, WON JUN LEE, EUN YOUNG LEE, SOO-A JUNG, SEUNG CHAN KIM, HA NA YU, MI JIN KIM, SEUNG-WOO HONG, SANG SOO PARK, JOONYEE JUNG, SEUNG MI KIM, EUN HO KIM, HONG-RAE JEONG, JI HEE GONG, JIEUN KIM, TAE WON KIM and DONG-HOON JIN
Anticancer Research April 2022, 42 (4) 1813-1819; DOI: https://doi.org/10.21873/anticanres.15657
JUN KI HONG
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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DO YEON KIM
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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JAE-SIK SHIN
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
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YEA SEONG RYU
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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JAI-HEE MOON
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
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DONG-IN KOH
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
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SEUL LEE
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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JINWOO LEE
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
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WON JUN LEE
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
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EUN YOUNG LEE
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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SOO-A JUNG
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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SEUNG CHAN KIM
3CJ HealthCare R&D Center, Icheon-si, Republic of Korea;
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HA NA YU
3CJ HealthCare R&D Center, Icheon-si, Republic of Korea;
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MI JIN KIM
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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SEUNG-WOO HONG
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
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SANG SOO PARK
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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JOONYEE JUNG
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
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SEUNG MI KIM
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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EUN HO KIM
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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HONG-RAE JEONG
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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JI HEE GONG
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
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JIEUN KIM
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
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TAE WON KIM
4Department of Oncology, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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  • For correspondence: twkimmd{at}amc.seoul.kr inno183{at}amc.seoul.kr
DONG-HOON JIN
1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
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  • For correspondence: twkimmd{at}amc.seoul.kr inno183{at}amc.seoul.kr
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Article Information

vol. 42 no. 4 1813-1819
DOI 
https://doi.org/10.21873/anticanres.15657
PMID 
35346999

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received December 30, 2021
  • Revision received February 6, 2022
  • Accepted February 11, 2022
  • Published online March 28, 2022.

Copyright & Usage 
Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. JUN KI HONG1,2,*,
  2. DO YEON KIM1,2,*,
  3. JAE-SIK SHIN1,*,
  4. YEA SEONG RYU1,2,
  5. JAI-HEE MOON1,
  6. DONG-IN KOH1,
  7. SEUL LEE1,2,
  8. JINWOO LEE1,
  9. WON JUN LEE1,
  10. EUN YOUNG LEE1,2,
  11. SOO-A JUNG1,2,
  12. SEUNG CHAN KIM3,
  13. HA NA YU3,
  14. MI JIN KIM1,2,
  15. SEUNG-WOO HONG1,
  16. SANG SOO PARK1,2,
  17. JOONYEE JUNG1,
  18. SEUNG MI KIM1,2,
  19. EUN HO KIM1,2,
  20. HONG-RAE JEONG1,2,
  21. JI HEE GONG1,
  22. JIEUN KIM1,
  23. TAE WON KIM4⇑ and
  24. DONG-HOON JIN1,2⇑
  1. 1Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea;
  2. 2Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
  3. 3CJ HealthCare R&D Center, Icheon-si, Republic of Korea;
  4. 4Department of Oncology, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
  1. Correspondence to: Tae Won Kim, MD, Ph.D., Department of Oncology, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympicro-43gil, Songpa-gu, Seoul 05505, Republic of Korea. E-mail: twkimmd{at}amc.seoul.kr and Dong-Hoon Jin, Ph.D., Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympicro-43gil, Songpa-gu, Seoul 05505, Republic of Korea. E-mail: inno183{at}amc.seoul.kr
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April 2022
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CJ14939, a Novel JAK Inhibitor, Increases Oxaliplatin-induced Cell Death Through JAK/STAT Pathway in Colorectal Cancer
JUN KI HONG, DO YEON KIM, JAE-SIK SHIN, YEA SEONG RYU, JAI-HEE MOON, DONG-IN KOH, SEUL LEE, JINWOO LEE, WON JUN LEE, EUN YOUNG LEE, SOO-A JUNG, SEUNG CHAN KIM, HA NA YU, MI JIN KIM, SEUNG-WOO HONG, SANG SOO PARK, JOONYEE JUNG, SEUNG MI KIM, EUN HO KIM, HONG-RAE JEONG, JI HEE GONG, JIEUN KIM, TAE WON KIM, DONG-HOON JIN
Anticancer Research Apr 2022, 42 (4) 1813-1819; DOI: 10.21873/anticanres.15657

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CJ14939, a Novel JAK Inhibitor, Increases Oxaliplatin-induced Cell Death Through JAK/STAT Pathway in Colorectal Cancer
JUN KI HONG, DO YEON KIM, JAE-SIK SHIN, YEA SEONG RYU, JAI-HEE MOON, DONG-IN KOH, SEUL LEE, JINWOO LEE, WON JUN LEE, EUN YOUNG LEE, SOO-A JUNG, SEUNG CHAN KIM, HA NA YU, MI JIN KIM, SEUNG-WOO HONG, SANG SOO PARK, JOONYEE JUNG, SEUNG MI KIM, EUN HO KIM, HONG-RAE JEONG, JI HEE GONG, JIEUN KIM, TAE WON KIM, DONG-HOON JIN
Anticancer Research Apr 2022, 42 (4) 1813-1819; DOI: 10.21873/anticanres.15657
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Keywords

  • JAK/STAT
  • CJ14939
  • JAK inhibitor
  • oxaliplatin
  • colorectal cancer
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