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Research ArticleExperimental Studies

Cytotoxic T Cells Activated by Self-differentiated Monocyte-derived Dendritic Cells Against Multiple Myeloma Cells

WANNASIRI CHIRAPHAPPHAIBOON, PIRIYA LUANGWATTANANUN, AUSSARA PANYA, NIPHAT JIRAPONGWATTANA, PRIMANA PUNNAKITIKASHEM, THAWEESAK CHIEOCHANSIN, MUTITA JUNKING and PA-THAI YENCHITSOMANUS
Anticancer Research April 2022, 42 (4) 1785-1799; DOI: https://doi.org/10.21873/anticanres.15655
WANNASIRI CHIRAPHAPPHAIBOON
1International Graduate Program in Medical Biochemistry and Molecular Biology, Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
2Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
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PIRIYA LUANGWATTANANUN
2Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
3Division of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
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AUSSARA PANYA
2Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
4Research Center in Bioresources for Agriculture, Industry and Medicine, Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand;
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NIPHAT JIRAPONGWATTANA
2Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
5International Graduate Program in Immunology, Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
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PRIMANA PUNNAKITIKASHEM
6Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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THAWEESAK CHIEOCHANSIN
2Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
3Division of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
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MUTITA JUNKING
2Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
3Division of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
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  • For correspondence: mutita.jun@mahidol.ac.th mjunking@gmail.com pathai.yen@mahidol.edu ptyench@gmail.com
PA-THAI YENCHITSOMANUS
2Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
3Division of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
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  • For correspondence: mutita.jun@mahidol.ac.th mjunking@gmail.com pathai.yen@mahidol.edu ptyench@gmail.com
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Abstract

Background/Aim: B cell maturation antigen (BCMA) is an ideal target for adoptive T cell therapy of multiple myeloma (MM). In this study, we evaluated self-differentiated monocyte-derived dendritic cells expressing BCMA (SD-DC-BCMA) to activate T cells for killing MM cells. Materials and Methods: Lentivirus-modified SD-DC-BCMA harboring tri-cistronic cDNAs encoding granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-4 (IL-4), and BCMA was generated. Cytotoxicity of T cells activated by SD-DC-BCMA against MM cells was evaluated. Results: T cells activated by SD-DC-BCMA exhibited a dose-dependent cytotoxicity against BCMA-expressing MM cells and produced high IFN-γ levels, compared to inactivated T cells or control T cells. A significantly higher killing ability of T cells activated by SD-DC-BCMA was further demonstrated in BCMA-overexpressing cells when compared with BCMA-negative cells. Conclusion: The potency of SD-DC-BCMA to activate T cells for antigen-specific cancer killing provides a framework for therapeutic application of adoptive T cell therapy in MM.

Key Words:
  • Multiple myeloma
  • adoptive T cell therapy
  • dendritic cells
  • cytotoxic T cells
  • B cell maturation antigen
  • Received November 4, 2021.
  • Revision received January 15, 2022.
  • Accepted February 10, 2022.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 42 (4)
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Cytotoxic T Cells Activated by Self-differentiated Monocyte-derived Dendritic Cells Against Multiple Myeloma Cells
WANNASIRI CHIRAPHAPPHAIBOON, PIRIYA LUANGWATTANANUN, AUSSARA PANYA, NIPHAT JIRAPONGWATTANA, PRIMANA PUNNAKITIKASHEM, THAWEESAK CHIEOCHANSIN, MUTITA JUNKING, PA-THAI YENCHITSOMANUS
Anticancer Research Apr 2022, 42 (4) 1785-1799; DOI: 10.21873/anticanres.15655

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Cytotoxic T Cells Activated by Self-differentiated Monocyte-derived Dendritic Cells Against Multiple Myeloma Cells
WANNASIRI CHIRAPHAPPHAIBOON, PIRIYA LUANGWATTANANUN, AUSSARA PANYA, NIPHAT JIRAPONGWATTANA, PRIMANA PUNNAKITIKASHEM, THAWEESAK CHIEOCHANSIN, MUTITA JUNKING, PA-THAI YENCHITSOMANUS
Anticancer Research Apr 2022, 42 (4) 1785-1799; DOI: 10.21873/anticanres.15655
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Keywords

  • Multiple myeloma
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