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Research ArticleClinical Studies

Highly Advanced Colorectal Liver Metastases Successfully Treated With Fluorouracil Plus Leucovorin Monotherapy and Microwave Ablation

KAZUKI MATSUMURA, KENSUKE YAMAMURA, HIDEAKI MIYAMOTO, YOSHIHIRO HARA, ERI ODA, SHINICHI AKAHOSHI, KENICHIRO YOSHIDA, HIDEAKI YUKI, TOSHIHIKO MOTOHARA, KATSUNORI SAKAMOTO, YOSHIHIRO KOMOHARA and TORU BEPPU
Anticancer Research March 2022, 42 (3) 1645-1651; DOI: https://doi.org/10.21873/anticanres.15641
KAZUKI MATSUMURA
1Department of Surgery, Yamaga City Medical Center, Yamaga, Japan
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KENSUKE YAMAMURA
1Department of Surgery, Yamaga City Medical Center, Yamaga, Japan
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HIDEAKI MIYAMOTO
2Department of Medical Oncology, Yamaga City Medical Center, Yamaga, Japan
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YOSHIHIRO HARA
1Department of Surgery, Yamaga City Medical Center, Yamaga, Japan
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ERI ODA
1Department of Surgery, Yamaga City Medical Center, Yamaga, Japan
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SHINICHI AKAHOSHI
1Department of Surgery, Yamaga City Medical Center, Yamaga, Japan
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KENICHIRO YOSHIDA
3Department of Radiology, Yamaga City Medical Center, Yamaga, Japan
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HIDEAKI YUKI
3Department of Radiology, Yamaga City Medical Center, Yamaga, Japan
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TOSHIHIKO MOTOHARA
4Department of Gastroenterology, Yamaga City Medical Center, Kumamoto, Japan
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KATSUNORI SAKAMOTO
5Department of Hepato-Biliary-Pancreatic and Breast Surgery, Ehime University Graduate School of Medicine, Toon, Japan
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YOSHIHIRO KOMOHARA
6Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
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TORU BEPPU
1Department of Surgery, Yamaga City Medical Center, Yamaga, Japan
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  • For correspondence: tbeppu@yamaga-mc.jp
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Abstract

Background: Fluorouracil plus leucovorin (5-FU/LV) is a less toxic but mild chemotherapy. Case Report: A 63-year-old male patient with rectal cancer and multiple colorectal liver metastases (CRLM, total volume of 1,826 ml) was hospitalized. He had several poor prognostic factors, including elevated levels of tumor markers, with carcinoembryonic antigen and carbohydrate antigen 19-9 levels of 17,119 ng/ml and 7,617 U/ml, respectively. Additionally, the patient had a low body mass index, poor performance status, and a history of apparent weight loss. After capecitabine and oxaliplatin for four cycles, 5-FU/LV has been lasting for nine months. Interestingly, tumor marker levels returned close to normal limits, and the total CRLM volume decreased to 154 ml without any enhancements. The patient’s general condition clearly improved after a year of chemotherapy. Conclusion: Chemotherapy with 5-FU/LV and percutaneous microwave ablation is beneficial to achieve tumor control in patients with highly advanced liver-only CRLM and poor general condition.

Key Words:
  • Colorectal liver metastases
  • fluorouracil plus leucovorin
  • microwave ablation
  • systemic chemotherapy
  • Received December 31, 2021.
  • Revision received January 17, 2022.
  • Accepted January 18, 2022.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 42 (3)
Anticancer Research
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Highly Advanced Colorectal Liver Metastases Successfully Treated With Fluorouracil Plus Leucovorin Monotherapy and Microwave Ablation
KAZUKI MATSUMURA, KENSUKE YAMAMURA, HIDEAKI MIYAMOTO, YOSHIHIRO HARA, ERI ODA, SHINICHI AKAHOSHI, KENICHIRO YOSHIDA, HIDEAKI YUKI, TOSHIHIKO MOTOHARA, KATSUNORI SAKAMOTO, YOSHIHIRO KOMOHARA, TORU BEPPU
Anticancer Research Mar 2022, 42 (3) 1645-1651; DOI: 10.21873/anticanres.15641

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Highly Advanced Colorectal Liver Metastases Successfully Treated With Fluorouracil Plus Leucovorin Monotherapy and Microwave Ablation
KAZUKI MATSUMURA, KENSUKE YAMAMURA, HIDEAKI MIYAMOTO, YOSHIHIRO HARA, ERI ODA, SHINICHI AKAHOSHI, KENICHIRO YOSHIDA, HIDEAKI YUKI, TOSHIHIKO MOTOHARA, KATSUNORI SAKAMOTO, YOSHIHIRO KOMOHARA, TORU BEPPU
Anticancer Research Mar 2022, 42 (3) 1645-1651; DOI: 10.21873/anticanres.15641
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Keywords

  • Colorectal liver metastases
  • fluorouracil plus leucovorin
  • microwave ablation
  • systemic chemotherapy
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