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Research ArticleClinical Studies

Outcome of Ordinary Polymorphous Adenocarcinomas of the Salivary Glands in Comparison With Papillary and Cribriform Subtypes

STELLA CLAUSEN, MARKUS FALK, FLORIAN OESTERLING, ANDRÉ FEHR, ANDREAS STANG, WERNER BOECKER, STEFAN GESK, STEFANIE SCHATZ, GÖRAN STENMAN, KATHARINA TIEMANN, THOMAS LOENING and REINHARD E. FRIEDRICH
Anticancer Research March 2022, 42 (3) 1455-1463; DOI: https://doi.org/10.21873/anticanres.15616
STELLA CLAUSEN
1Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany;
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MARKUS FALK
2Institute for Hematopathology, Hamburg, Germany;
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  • For correspondence: falk@hp-hamburg.de
FLORIAN OESTERLING
3Cancer Registry North Rhine-Westphalia, Bochum, Germany;
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ANDRÉ FEHR
4Sahlgrenska Center for Cancer Research, Department of Pathology, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden;
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ANDREAS STANG
3Cancer Registry North Rhine-Westphalia, Bochum, Germany;
5Institute of Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany;
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WERNER BOECKER
6Gerhard Seifert Reference-Center - Hansepathnet, Hamburg, Germany;
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STEFAN GESK
7Institute for Tumor Genetics North, Kiel, Germany
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STEFANIE SCHATZ
2Institute for Hematopathology, Hamburg, Germany;
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GÖRAN STENMAN
4Sahlgrenska Center for Cancer Research, Department of Pathology, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden;
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KATHARINA TIEMANN
2Institute for Hematopathology, Hamburg, Germany;
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THOMAS LOENING
6Gerhard Seifert Reference-Center - Hansepathnet, Hamburg, Germany;
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REINHARD E. FRIEDRICH
1Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany;
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Abstract

Background/Aim: Polymorphous adenocarcinoma (PAC) is a low-grade salivary gland malignancy in contrast to variants with papillary (PAP) or cribriform (CASG) architecture and confers the second most common malignancy of minor salivary glands. Our study aimed to identify prognostic factors and to evaluate histomorphological and molecular diagnostic criteria of PACs. Patients and Methods: A series of 155 PACs, including 10 PAPs and 12 CASGs from the population-based Cancer Registry of North Rhine-Westphalia (LKR-NRW) and the Hamburg Salivary Gland Reference Centre (HRC) were analyzed. Results: One fifth of the tumors were located in the major salivary glands and PACS/CASGS invariably lacked p40 expression. Fifty-two percent of PACs showed a PRKD1 E710D mutation. Ordinary PACs had a disease-specific 10-year survival probability of 97% compared to 90% when combining PAPs and CASGs. T-stage at diagnosis was a prognostic factor with 98% for stages T1/T2 versus 75% for T3/T4. Conclusion: Diagnostic algorithms for the PAC/CASG spectrum of tumors need to be improved and should include molecular markers.

Key Words:
  • Salivary gland tumor
  • polymorphous adenocarcinoma
  • polymorphous low-grade adenocarcinoma
  • PRKD1
  • cribriform adenocarcinoma of salivary glands
  • molecular diagnostics
  • Received December 20, 2021.
  • Revision received January 17, 2022.
  • Accepted January 19, 2022.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 42 (3)
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Outcome of Ordinary Polymorphous Adenocarcinomas of the Salivary Glands in Comparison With Papillary and Cribriform Subtypes
STELLA CLAUSEN, MARKUS FALK, FLORIAN OESTERLING, ANDRÉ FEHR, ANDREAS STANG, WERNER BOECKER, STEFAN GESK, STEFANIE SCHATZ, GÖRAN STENMAN, KATHARINA TIEMANN, THOMAS LOENING, REINHARD E. FRIEDRICH
Anticancer Research Mar 2022, 42 (3) 1455-1463; DOI: 10.21873/anticanres.15616

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Outcome of Ordinary Polymorphous Adenocarcinomas of the Salivary Glands in Comparison With Papillary and Cribriform Subtypes
STELLA CLAUSEN, MARKUS FALK, FLORIAN OESTERLING, ANDRÉ FEHR, ANDREAS STANG, WERNER BOECKER, STEFAN GESK, STEFANIE SCHATZ, GÖRAN STENMAN, KATHARINA TIEMANN, THOMAS LOENING, REINHARD E. FRIEDRICH
Anticancer Research Mar 2022, 42 (3) 1455-1463; DOI: 10.21873/anticanres.15616
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Keywords

  • Salivary gland tumor
  • polymorphous adenocarcinoma
  • polymorphous low-grade adenocarcinoma
  • PRKD1
  • cribriform adenocarcinoma of salivary glands
  • molecular diagnostics
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