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Research ArticleClinical Studies

A Rare Case of Brain Metastasis of Thymic Carcinoma

TAKAAKI MITSUI, RYOSUKE MATSUDA, KAZUO GODA, HIROE ITAMI, ICHIRO NAKAGAWA and HIROYUKI NAKASE
Anticancer Research February 2022, 42 (2) 1169-1174; DOI: https://doi.org/10.21873/anticanres.15582
TAKAAKI MITSUI
1Department of Neurosurgery, Heisei Memorial Hospital, Kashihara, Japan
2Department of Neurosurgery, Nara Medical University, Kashihara, Japan
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RYOSUKE MATSUDA
2Department of Neurosurgery, Nara Medical University, Kashihara, Japan
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  • For correspondence: rmatsuda@naramed-u.ac.jp
KAZUO GODA
1Department of Neurosurgery, Heisei Memorial Hospital, Kashihara, Japan
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HIROE ITAMI
3Department of Diagnostic Pathology, Nara Medical University, Kashihara, Japan
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ICHIRO NAKAGAWA
2Department of Neurosurgery, Nara Medical University, Kashihara, Japan
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HIROYUKI NAKASE
2Department of Neurosurgery, Nara Medical University, Kashihara, Japan
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Abstract

Background: Thymic carcinoma is a rare cancer that often metastasizes to the liver and kidneys but rarely to the brain. Case Report: We present a rare case of an 81-year-old woman with multiple cerebellar metastases of thymic carcinoma. She was initially diagnosed with stage IVb thymic carcinoma based on biopsy examination of a lesion in the anterior mediastinum. The patient refused to undergo treatment at the time. Six months later, she presented with gait disturbance and nausea. Contrast-enhanced magnetic resonance imaging revealed multiple cerebellar metastases. She underwent craniotomy and resection of the left cerebellar metastasis. Postoperative histological examination confirmed metastasis of the original thymic carcinoma. The patient underwent additional stereotactic radiotherapy for the cavity of the cerebellar metastasis and the small cerebellar metastatic lesions. Seven months after radiotherapy, she died due to progression of the thymic carcinoma. Conclusion: We believe that these findings add important information to the literature on this rare entity.

Key Words:
  • Brain metastasis
  • thymic carcinoma
  • cerebellar metastasis
  • stereotactic radiotherapy
  • Received December 2, 2021.
  • Revision received December 14, 2021.
  • Accepted January 7, 2022.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 42 (2)
Anticancer Research
Vol. 42, Issue 2
February 2022
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A Rare Case of Brain Metastasis of Thymic Carcinoma
TAKAAKI MITSUI, RYOSUKE MATSUDA, KAZUO GODA, HIROE ITAMI, ICHIRO NAKAGAWA, HIROYUKI NAKASE
Anticancer Research Feb 2022, 42 (2) 1169-1174; DOI: 10.21873/anticanres.15582

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A Rare Case of Brain Metastasis of Thymic Carcinoma
TAKAAKI MITSUI, RYOSUKE MATSUDA, KAZUO GODA, HIROE ITAMI, ICHIRO NAKAGAWA, HIROYUKI NAKASE
Anticancer Research Feb 2022, 42 (2) 1169-1174; DOI: 10.21873/anticanres.15582
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Keywords

  • Brain metastasis
  • Thymic carcinoma
  • cerebellar metastasis
  • stereotactic radiotherapy
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