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Research ArticleExperimental Studies

Eupatilin Suppresses Pancreatic Cancer Cells via Glucose Uptake Inhibition, AMPK Activation, and Cell Cycle Arrest

TAE HYUN PARK and HYEON SOO KIM
Anticancer Research January 2022, 42 (1) 483-491; DOI: https://doi.org/10.21873/anticanres.15506
TAE HYUN PARK
Department of Anatomy, Korea University College of Medicine, Seoul, Republic of Korea
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HYEON SOO KIM
Department of Anatomy, Korea University College of Medicine, Seoul, Republic of Korea
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  • For correspondence: anatomykim@korea.ac.kr
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Abstract

Background/Aim: Pancreatic cancer is one of the most devastating malignancies worldwide. Because of the disappointing outcome of traditional treatment, new drug candidates are being investigated. This study analysed the effect of eupatilin on pancreatic cancer cells. Materials and Methods: Cell viability assay, western blot, siRNA transfection, 2-deoxyglucose uptake assay, AMP/ADP/ATP assay, and fluorescent activated cell sorting were performed. Results: Eupatilin decreased cell viability and activated AMPK in MIA-PaCa2 cells. Eupatilin decreased glucose uptake in pancreatic cancer, which led to cell starvation and AMPK activation. It is well known that AMPK induces p21 and cell cycle arrest by activating p53. In MIA-PaCa2 cells, p53 is mutated and wild-type p53 protein is suppressed. Treatment with eupatilin induced p21 expression but inhibited the expression of mutated p53. Eupatilin activated Tap73, a p53 family member, which can substitute wild-type p53’s role. Conclusion: Eupatilin shows an anticancer effect against pancreatic cancer cells via glucose uptake inhibition, AMPK activation, and cell cycle arrest.

Key Words:
  • Eupatilin
  • AMPK
  • glucose uptake
  • cell cycle arrest
  • Tap73
  • Received October 9, 2021.
  • Revision received November 8, 2021.
  • Accepted November 11, 2021.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 42 (1)
Anticancer Research
Vol. 42, Issue 1
January 2022
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Eupatilin Suppresses Pancreatic Cancer Cells via Glucose Uptake Inhibition, AMPK Activation, and Cell Cycle Arrest
TAE HYUN PARK, HYEON SOO KIM
Anticancer Research Jan 2022, 42 (1) 483-491; DOI: 10.21873/anticanres.15506

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Eupatilin Suppresses Pancreatic Cancer Cells via Glucose Uptake Inhibition, AMPK Activation, and Cell Cycle Arrest
TAE HYUN PARK, HYEON SOO KIM
Anticancer Research Jan 2022, 42 (1) 483-491; DOI: 10.21873/anticanres.15506
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Keywords

  • Eupatilin
  • AMPK
  • glucose uptake
  • cell cycle arrest
  • Tap73
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