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Review ArticleReview

Fatigue in Cancer Treatment Studies: Analysis of Placebo Arms

HOLGER HAUCH, BIRTE J. WOLFF and JOHANNES E. WOLFF
Anticancer Research January 2022, 42 (1) 45-52; DOI: https://doi.org/10.21873/anticanres.15455
HOLGER HAUCH
1Pediatric Hematology and Oncology, University Children’s Hospital Giessen, Hesse, Germany;
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BIRTE J. WOLFF
2Swedish Covenant Hospital Department of Gynecology, Chicago, IL, U.S.A.;
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JOHANNES E. WOLFF
3AbbVie Inc, North Chicago, IL, U.S.A.
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  • For correspondence: johannesewolff{at}gmail.com
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    Figure 1.

    Fatigue/asthenia reported according to cancer organ. Data were restricted to placebo arms of randomized trials with no other cancer therapeutic. Asthenia and fatigue are combined as one variable, regardless of which term was used in reporting. GIST: Gastrointestinal stroma tumors.

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    Figure 2.

    Correlation of nausea with fatigue/asthenia reported in randomized clinical trials. Asthenia and fatigue were combined as one variable, regardless of which term was used in reporting. Percentage values reflect the sum of all grades (grade 1 or higher). The line of best fit was plotted for the total data. The correlation between nausea and fatigue/asthenia was significant among all data, and among subgroups of both treatment and placebo groups.

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January 2022
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Fatigue in Cancer Treatment Studies: Analysis of Placebo Arms
HOLGER HAUCH, BIRTE J. WOLFF, JOHANNES E. WOLFF
Anticancer Research Jan 2022, 42 (1) 45-52; DOI: 10.21873/anticanres.15455

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Fatigue in Cancer Treatment Studies: Analysis of Placebo Arms
HOLGER HAUCH, BIRTE J. WOLFF, JOHANNES E. WOLFF
Anticancer Research Jan 2022, 42 (1) 45-52; DOI: 10.21873/anticanres.15455
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Keywords

  • meta-analysis
  • systematic review
  • Adverse events
  • asthenia
  • fatigue
  • placebo
  • cancer
  • oncology
  • randomized trials
  • CTCAE
  • review
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