Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

Prognostic Value of Copine 1 in Patients With Renal Cell Carcinoma

IMAN M. TALAAT, EMAN ABU-GHARBIEH, AMAL HUSSEIN, MAHMOOD HACHIM, ISRAA SOBHY, MOHAMED ELADL and WASEEM EL-HUNEIDI
Anticancer Research January 2022, 42 (1) 355-362; DOI: https://doi.org/10.21873/anticanres.15493
IMAN M. TALAAT
1College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
2Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
EMAN ABU-GHARBIEH
1College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
AMAL HUSSEIN
1College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MAHMOOD HACHIM
3College of Medicine, Mohammed bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ISRAA SOBHY
2Pathology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MOHAMED ELADL
1College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
WASEEM EL-HUNEIDI
1College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: welhuneidi@sharjah.ac.ae
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Background/Aim: Renal cell carcinoma (RCC) is among the most common renal malignancies and requires reliable biomarkers for optimum diagnosis and prognosis. Copines are a family of calcium-dependent phospholipid-binding proteins that were reported to be associated with various cancers. We aimed to investigate the prognostic value of Copines 1 and 3 in RCC patients. Materials and Methods: Copines 1 and 3 bioinformatics analysis and immunohistochemical (IHC) staining were performed on patients with RCC. Results: The findings revealed significant association between Copine 1 expression and the patients’ age, nuclear grade, and tumor stage. Bioinformatics analysis showed a similar trend for the mRNA expression of CPNE1, the gene that encodes Copine 1. Interestingly, results revealed a positive association between Copine 1 and both EphA and Ki-67 expression levels. Noteworthy, there was no significant association between Copine 3 expression and any parameters. Conclusion: Copine 1 may be used as an independent biomarker or in combination with both EphA2 and Ki-67 to predict disease outcome.

Key Words
  • Copine 1
  • renal cell carcinoma
  • immunohistochemistry
  • prognostic marker
  • bioinformatics
  • Received October 13, 2021.
  • Revision received November 14, 2021.
  • Accepted November 15, 2021.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
View Full Text

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

patientACCESS

patientACCESS - Patients desiring access to articles
PreviousNext
Back to top

In this issue

Anticancer Research: 42 (1)
Anticancer Research
Vol. 42, Issue 1
January 2022
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Prognostic Value of Copine 1 in Patients With Renal Cell Carcinoma
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
15 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Prognostic Value of Copine 1 in Patients With Renal Cell Carcinoma
IMAN M. TALAAT, EMAN ABU-GHARBIEH, AMAL HUSSEIN, MAHMOOD HACHIM, ISRAA SOBHY, MOHAMED ELADL, WASEEM EL-HUNEIDI
Anticancer Research Jan 2022, 42 (1) 355-362; DOI: 10.21873/anticanres.15493

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Prognostic Value of Copine 1 in Patients With Renal Cell Carcinoma
IMAN M. TALAAT, EMAN ABU-GHARBIEH, AMAL HUSSEIN, MAHMOOD HACHIM, ISRAA SOBHY, MOHAMED ELADL, WASEEM EL-HUNEIDI
Anticancer Research Jan 2022, 42 (1) 355-362; DOI: 10.21873/anticanres.15493
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Conclusion
    • Funding
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Pelvic Recurrence After Curative Resection for Rectal Adenocarcinoma: Impact of Surgery on Survival
  • Glasgow Prognostic Score Predicts Survival and Recurrence Pattern in Patients With Hepatocellular Carcinoma After Hepatectomy
  • Small Bowel Lipomatosis: An Unusual Radiological Finding in Patients With Renal Cell Cancer on Pazopanib
Show more Clinical Studies

Similar Articles

Keywords

  • Copine 1
  • Renal cell carcinoma
  • immunohistochemistry
  • prognostic marker
  • bioinformatics
Anticancer Research

© 2023 Anticancer Research

Powered by HighWire