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Research ArticleClinical Studies

Correlation Between Clinical Outcomes and Serum CA-125 Levels After Standard Treatment for Epithelial Ovarian Cancer

JUHUN LEE, JONG MI KIM, YOON HEE LEE, GUN OH CHONG and DAE GY HONG
Anticancer Research January 2022, 42 (1) 349-353; DOI: https://doi.org/10.21873/anticanres.15492
JUHUN LEE
Department of Obstetrics and Gynecology, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea
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JONG MI KIM
Department of Obstetrics and Gynecology, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea
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YOON HEE LEE
Department of Obstetrics and Gynecology, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea
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GUN OH CHONG
Department of Obstetrics and Gynecology, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea
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DAE GY HONG
Department of Obstetrics and Gynecology, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea
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  • For correspondence: dghong@knu.ac.kr
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Abstract

Background/Aim: To analyze the relationship between clinical outcomes for epithelial ovarian cancer and serum CA-125 levels after chemotherapy in Korean women. Patients and Methods: This study included 183 patients who underwent the standard treatment regimen for epithelial ovarian cancer. They were divided into early- (I, II) and advanced-stage (III, IV) groups. Serum CA-125 level after adjuvant chemotherapy completion (post-chemotherapy; PC-CA-125) was measured. Overall survival (OS), progression-free survival (PFS), platinum-free interval (PFI), and platinum resistance were evaluated. Results: In advanced-stage group, OS, PFS, PFI, and platinum resistance were significantly correlated with PC-CA-125. In early-stage group, PFS and platinum resistance differed significantly. Cutoff value for platinum resistance was 10.45 U/ml, 10.40 U/ml, and 15.80 U/ml for study population, early stage, and advanced groups, respectively. Accuracy was 71.1%-77.1%. Conclusion: PC-CA-125 is correlated with clinical outcomes in ovarian cancer. Thus, CA-125 can be used to predict platinum resistance in ovarian cancer treatment.

Key Words
  • Ovarian cancer
  • chemotherapy
  • clinical outcomes
  • overall survival
  • progression-free survival
  • platinum-free interval
  • platinum resistance
  • CA-125
  • Received October 28, 2021.
  • Revision received November 17, 2021.
  • Accepted November 19, 2021.
  • Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 42 (1)
Anticancer Research
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Correlation Between Clinical Outcomes and Serum CA-125 Levels After Standard Treatment for Epithelial Ovarian Cancer
JUHUN LEE, JONG MI KIM, YOON HEE LEE, GUN OH CHONG, DAE GY HONG
Anticancer Research Jan 2022, 42 (1) 349-353; DOI: 10.21873/anticanres.15492

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Correlation Between Clinical Outcomes and Serum CA-125 Levels After Standard Treatment for Epithelial Ovarian Cancer
JUHUN LEE, JONG MI KIM, YOON HEE LEE, GUN OH CHONG, DAE GY HONG
Anticancer Research Jan 2022, 42 (1) 349-353; DOI: 10.21873/anticanres.15492
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Keywords

  • ovarian cancer
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  • Overall survival
  • progression-free survival
  • platinum-free interval
  • platinum resistance
  • CA-125
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