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Research ArticleClinical Studies

Mesonephric-like Differentiation of Ovarian Endometrioid and High-grade Serous Carcinomas: Clinicopathological and Molecular Characteristics Distinct from Those of Mesonephric-like Adenocarcinoma

KYUE-HEE CHOI, HYUNJIN KIM, GO EUN BAE, SANG HWA LEE, HA YOUNG WOO and HYUN-SOO KIM
Anticancer Research September 2021, 41 (9) 4587-4601; DOI: https://doi.org/10.21873/anticanres.15272
KYUE-HEE CHOI
1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
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HYUNJIN KIM
1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
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GO EUN BAE
2Department of Pathology, Chungnam National University School of Medicine, Daejeon, Republic of Korea;
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SANG HWA LEE
3Pathology Center, Seegene Medical Foundation, Seoul, Republic of Korea;
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HA YOUNG WOO
4Department of Pathology, National Cancer Center, Goyang, Republic of Korea
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  • For correspondence: hyun-soo.kim@samsung.com why@ncc.re.kr
HYUN-SOO KIM
1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
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  • For correspondence: hyun-soo.kim@samsung.com why@ncc.re.kr
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Abstract

Background/Aim: Ovarian endometrioid carcinoma (EC) and high-grade serous carcinoma (HGSC) may exhibit various growth patterns and mimic mesonephric-like adenocarcinoma (MLA). We investigated the clinicopathological and molecular features of ovarian carcinomas with mesonephric-like differentiation (MLD). Patients and Methods: We analyzed the electronic medical records and pathology slides of two EC-MLD and three HGSC-MLD patients, and conducted immunostaining and targeted sequencing of their samples. Results: All cases showed architectural diversity, compactly aggregated small tubules and ducts, and eosinophilic intraluminal secretions, indicating the possibility of an ovarian MLA. However, the following histological and immunophenotypical features confirmed the diagnoses of EC-MLD and HGSC-MLD: squamous, tubal, and sertoliform differentiation; serous tubal intraepithelial carcinoma; solid, endometrioid, transitional (SET) feature; solid, transitional, endometrioid, mucinous-like (STEM) feature; diffuse expression of hormone receptors and Wilms tumor 1; mutant p53 immunostaining pattern; and wild-type v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog gene. Conclusion: A subset of ovarian ECs and HGSCs can display MLD and mimic an MLA. A thorough histological examination combined with ancillary tests is crucial to differentiate between these ovarian neoplastic entities.

Key Words:
  • Ovary
  • endometrioid carcinoma
  • high-grade serous carcinoma
  • mesonephric-like differentiation
  • mesonephric-like adenocarcinoma
  • Received June 20, 2021.
  • Revision received July 7, 2021.
  • Accepted July 8, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (9)
Anticancer Research
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September 2021
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Mesonephric-like Differentiation of Ovarian Endometrioid and High-grade Serous Carcinomas: Clinicopathological and Molecular Characteristics Distinct from Those of Mesonephric-like Adenocarcinoma
KYUE-HEE CHOI, HYUNJIN KIM, GO EUN BAE, SANG HWA LEE, HA YOUNG WOO, HYUN-SOO KIM
Anticancer Research Sep 2021, 41 (9) 4587-4601; DOI: 10.21873/anticanres.15272

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Mesonephric-like Differentiation of Ovarian Endometrioid and High-grade Serous Carcinomas: Clinicopathological and Molecular Characteristics Distinct from Those of Mesonephric-like Adenocarcinoma
KYUE-HEE CHOI, HYUNJIN KIM, GO EUN BAE, SANG HWA LEE, HA YOUNG WOO, HYUN-SOO KIM
Anticancer Research Sep 2021, 41 (9) 4587-4601; DOI: 10.21873/anticanres.15272
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Keywords

  • Ovary
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