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Research ArticleClinical Studies

The Use of CT Pattern in Differentiating Non-invasive, Minimally Invasive and Invasive Variants of Lung Adenocarcinoma

HYNEK MIRKA, JIRI FERDA, GABRIELA KRAKOROVA, JOSEF VODICKA, PETR MUKENSNABL, ONDREJ TOPOLCAN and RADEK KUCERA
Anticancer Research September 2021, 41 (9) 4479-4482; DOI: https://doi.org/10.21873/anticanres.15257
HYNEK MIRKA
1Department of Medical Imaging, Faculty of Medicine and University Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic;
2Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, Pilsen, Czech Republic;
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  • For correspondence: mirka@fnplzen.cz
JIRI FERDA
1Department of Medical Imaging, Faculty of Medicine and University Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic;
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GABRIELA KRAKOROVA
3Department of Pneumology and Ftiseology, Faculty of Medicine and University Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic;
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JOSEF VODICKA
4Department of Surgery, Faculty of Medicine and University Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic;
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PETR MUKENSNABL
5Sikl’s Department of Pathology, Faculty of Medicine and University Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic;
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ONDREJ TOPOLCAN
6Division of Immunochemical Diagnostics, Faculty of Medicine and University Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic
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RADEK KUCERA
6Division of Immunochemical Diagnostics, Faculty of Medicine and University Hospital in Pilsen, Charles University in Prague, Pilsen, Czech Republic
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Abstract

Background/Aim: This study determined whether computed tomography (CT) is an appropriate means by which to differentiate non-invasive and minimally invasive forms of pulmonary adenocarcinoma from the invasive variant. Patients and Methods: A total of 64 patients (38 men and 26 women, aged 42-76, mean age 64), who underwent surgery for pulmonary adenocarcinoma and a chest CT no less than 1 month before surgery, were included in the study. Lesions exhibiting ground glass opacity or ground glass opacity with a solid component of 5 mm or smaller, were defined as minimally invasive or non-invasive adenocarcinomas. CT findings were correlated with histopathological examination. Results: Distinguishing minimally invasive and non-invasive adenocarcinoma from invasive adenocarcinoma using CT was achieved with a sensitivity of 77.7%, a specificity of 97.8%, a positive predictive value of 93.3%, and a negative predictive value of 91.8%. Conclusion: CT can be useful in assessing the degree of invasiveness of pulmonary adenocarcinoma and is a potential tool for the individualization of treatment.

Key Words:
  • Lung
  • tumor
  • pulmonary nodule
  • adenocarcinoma
  • histological type
  • diagnostic imaging
  • computed tomography
  • Received May 2, 2021.
  • Revision received July 15, 2021.
  • Accepted July 16, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (9)
Anticancer Research
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September 2021
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The Use of CT Pattern in Differentiating Non-invasive, Minimally Invasive and Invasive Variants of Lung Adenocarcinoma
HYNEK MIRKA, JIRI FERDA, GABRIELA KRAKOROVA, JOSEF VODICKA, PETR MUKENSNABL, ONDREJ TOPOLCAN, RADEK KUCERA
Anticancer Research Sep 2021, 41 (9) 4479-4482; DOI: 10.21873/anticanres.15257

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The Use of CT Pattern in Differentiating Non-invasive, Minimally Invasive and Invasive Variants of Lung Adenocarcinoma
HYNEK MIRKA, JIRI FERDA, GABRIELA KRAKOROVA, JOSEF VODICKA, PETR MUKENSNABL, ONDREJ TOPOLCAN, RADEK KUCERA
Anticancer Research Sep 2021, 41 (9) 4479-4482; DOI: 10.21873/anticanres.15257
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Keywords

  • Lung
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  • pulmonary nodule
  • adenocarcinoma
  • histological type
  • diagnostic imaging
  • computed tomography
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