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Research ArticleExperimental Studies

TrkB/BDNF Signaling Could Be a New Therapeutic Target for Pancreatic Cancer

YASUHIRO OYAMA, SHINJIRO NAGAO, LIN NA, KOSUKE YANAI, MASAYO UMEBAYASHI, KATSUYA NAKAMURA, SHUNTARO NAGAI, AKIKO FUJIMURA, AKIO YAMASAKI, KAZUNORI NAKAYAMA, TAKASHI MORISAKI and HIDEYA ONISHI
Anticancer Research August 2021, 41 (8) 4047-4052; DOI: https://doi.org/10.21873/anticanres.15205
YASUHIRO OYAMA
1Departments of Cancer Therapy and Research, Kyushu University, Fukuoka, Japan;
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SHINJIRO NAGAO
1Departments of Cancer Therapy and Research, Kyushu University, Fukuoka, Japan;
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LIN NA
1Departments of Cancer Therapy and Research, Kyushu University, Fukuoka, Japan;
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KOSUKE YANAI
2Departments of Surgery and Oncologys, Kyushu University, Fukuoka, Japan;
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MASAYO UMEBAYASHI
3Fukuoka General Cancer Clinic, Fukuoka, Japan
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KATSUYA NAKAMURA
2Departments of Surgery and Oncologys, Kyushu University, Fukuoka, Japan;
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SHUNTARO NAGAI
2Departments of Surgery and Oncologys, Kyushu University, Fukuoka, Japan;
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AKIKO FUJIMURA
1Departments of Cancer Therapy and Research, Kyushu University, Fukuoka, Japan;
4Departments of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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AKIO YAMASAKI
1Departments of Cancer Therapy and Research, Kyushu University, Fukuoka, Japan;
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KAZUNORI NAKAYAMA
1Departments of Cancer Therapy and Research, Kyushu University, Fukuoka, Japan;
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TAKASHI MORISAKI
3Fukuoka General Cancer Clinic, Fukuoka, Japan
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HIDEYA ONISHI
1Departments of Cancer Therapy and Research, Kyushu University, Fukuoka, Japan;
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  • For correspondence: ohnishi@surg1.med.kyushu-u.ac.jp
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Abstract

Background/Aim: Tropomyosin-related kinase B (TrkB)/brain-derived neurotrophic factor (BDNF) signaling plays a role in inducing malignant phenotypes in several aggressive types of cancers. To create a conclusive therapy targeting TrkB/BDNF signaling in solid refractory cancers, the biological significance of TrkB/BDNF signaling was analyzed in pancreatic ductal adenocarcinoma (PDAC) cells. Materials and Methods: Three PDAC cell lines were used as target cells to investigate proliferation and invasiveness. Small interfering RNA (siRNA) and the TrkB tyrosine kinase inhibitor k252a were used as TrkB/BDNF signaling inhibitors. Results: All PDAC cell lines expressed TrkB and BDNF. When TrkB and BDNF were inhibited by siRNA or k252a, the invasiveness of PANC-1 and SUIT-2 cells significantly decreased. When TrkB was inhibited by siRNA or k252a, proliferation was significantly inhibited in PDAC cells. Conclusion: TrkB/BDNF signaling may be a new therapeutic target for PDAC. Therapies targeting TrkB/BDNF signaling may be a conclusive cancer therapy for refractory solid cancer.

Key Words:
  • TrkB
  • BDNF
  • pancreatic cancer
  • proliferation
  • invasion
  • Received May 22, 2021.
  • Revision received June 28, 2021.
  • Accepted June 29, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (8)
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TrkB/BDNF Signaling Could Be a New Therapeutic Target for Pancreatic Cancer
YASUHIRO OYAMA, SHINJIRO NAGAO, LIN NA, KOSUKE YANAI, MASAYO UMEBAYASHI, KATSUYA NAKAMURA, SHUNTARO NAGAI, AKIKO FUJIMURA, AKIO YAMASAKI, KAZUNORI NAKAYAMA, TAKASHI MORISAKI, HIDEYA ONISHI
Anticancer Research Aug 2021, 41 (8) 4047-4052; DOI: 10.21873/anticanres.15205

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TrkB/BDNF Signaling Could Be a New Therapeutic Target for Pancreatic Cancer
YASUHIRO OYAMA, SHINJIRO NAGAO, LIN NA, KOSUKE YANAI, MASAYO UMEBAYASHI, KATSUYA NAKAMURA, SHUNTARO NAGAI, AKIKO FUJIMURA, AKIO YAMASAKI, KAZUNORI NAKAYAMA, TAKASHI MORISAKI, HIDEYA ONISHI
Anticancer Research Aug 2021, 41 (8) 4047-4052; DOI: 10.21873/anticanres.15205
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Keywords

  • TrkB
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  • Pancreatic cancer
  • proliferation
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