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Research ArticleExperimental Studies

The Prognostic Significance of Plakophilin-1 Expression in Esophageal Cancer

JUNKI FUJITA, MASANOBU NAKAJIMA, HIROTO MUROI, MAIKO KIKUCHI, KEISUKE IHARA, TAKESHI YAMAGUCHI, MASATOSHI NAKAGAWA, SHINJI MORITA, TAKATOSHI NAKAMURA, TAKASHI TSUCHIOKA and KAZUYUKI KOJIMA
Anticancer Research July 2021, 41 (7) 3401-3407; DOI: https://doi.org/10.21873/anticanres.15127
JUNKI FUJITA
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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MASANOBU NAKAJIMA
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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  • For correspondence: mnakajim@dokkyomed.ac.jp
HIROTO MUROI
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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MAIKO KIKUCHI
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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KEISUKE IHARA
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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TAKESHI YAMAGUCHI
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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MASATOSHI NAKAGAWA
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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SHINJI MORITA
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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TAKATOSHI NAKAMURA
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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TAKASHI TSUCHIOKA
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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KAZUYUKI KOJIMA
First Department of Surgery, Dokkyo Medical University, Mibu, Japan
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Abstract

Background/Aim: Plakophilin 1 (PKP1) expression is inversely related to cancer grade. This study aimed to evaluate whether PKP1 is a prognostic marker for esophageal cancer (EC). Materials and Methods: We tested immunohistochemically for PKP1 in squamous cell carcinoma EC specimens from 99 patients, including cytoplasmic (C), membrane (M), and nuclear (N) cellular areas, and analyzed their relationships with clinicopathological factors. Results: PKP1stains were stratified into strong and weak for all three cellular areas. Staining was inversely related to tumor depth (C: p=0.002, M: p=0.00007, N: p=0.02), lymph node metastasis (C: p=0.003, M: p=0.001, N: p=0.004) and pathological stage (C: p=0.0004, M: p=0.0001, N: p=0.006). Cytoplasmic and membrane staining were inversely related to vessel invasion. Patients with strong C stain had a better overall survival than those with weak C stains (p=0.01). Disease-free survival of patients with strong M stains was better than that of those with weak staining (p=0.01). Conclusion: Cytoplasmic and membrane PKP1 expression is a possible prognostic marker for EC.

Key Words:
  • Esophageal cancer
  • squamous cell carcinoma
  • plakophilin-1
  • prognostic marker
  • Received March 31, 2021.
  • Revision received May 12, 2021.
  • Accepted May 26, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (7)
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July 2021
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The Prognostic Significance of Plakophilin-1 Expression in Esophageal Cancer
JUNKI FUJITA, MASANOBU NAKAJIMA, HIROTO MUROI, MAIKO KIKUCHI, KEISUKE IHARA, TAKESHI YAMAGUCHI, MASATOSHI NAKAGAWA, SHINJI MORITA, TAKATOSHI NAKAMURA, TAKASHI TSUCHIOKA, KAZUYUKI KOJIMA
Anticancer Research Jul 2021, 41 (7) 3401-3407; DOI: 10.21873/anticanres.15127

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The Prognostic Significance of Plakophilin-1 Expression in Esophageal Cancer
JUNKI FUJITA, MASANOBU NAKAJIMA, HIROTO MUROI, MAIKO KIKUCHI, KEISUKE IHARA, TAKESHI YAMAGUCHI, MASATOSHI NAKAGAWA, SHINJI MORITA, TAKATOSHI NAKAMURA, TAKASHI TSUCHIOKA, KAZUYUKI KOJIMA
Anticancer Research Jul 2021, 41 (7) 3401-3407; DOI: 10.21873/anticanres.15127
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Keywords

  • Esophageal cancer
  • squamous cell carcinoma
  • plakophilin-1
  • prognostic marker
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