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Research ArticleExperimental Studies

The Association of MMP9 Promoter Rs3918242 Genotype With Gastric Cancer

CHUN-KAI FU, WEN-SHIN CHANG, CHIA-WEN TSAI, YUN-CHI WANG, MEI-DUE YANG, HUA-SHAI HSU, CHE-YI CHAO, CHIEN-CHIH YU, JAW-CHYUN CHEN, JEN-SHENG PEI and DA-TIAN BAU
Anticancer Research July 2021, 41 (7) 3309-3315; DOI: https://doi.org/10.21873/anticanres.15118
CHUN-KAI FU
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
2Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.;
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
4National Defense Medical Center, Taipei, Taiwan, R.O.C.;
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WEN-SHIN CHANG
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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CHIA-WEN TSAI
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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YUN-CHI WANG
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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MEI-DUE YANG
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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HUA-SHAI HSU
5Department of Medical Imaging, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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CHE-YI CHAO
6Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.;
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CHIEN-CHIH YU
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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JAW-CHYUN CHEN
7Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.;
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JEN-SHENG PEI
8Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.;
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DA-TIAN BAU
1Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
3Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
9Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
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  • For correspondence: artbau2@gmail.com
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Abstract

Background/Aim: Matrix metalloproteinase 9 (MMP9) is highly expressed in gastric cancer but the role of MMP9 is unclear. This study aimed at revealing the association of MMP9 promoter rs3918242 genotypes with gastric cancer risk. Materials and Methods: MMP9 rs3918242 genotypes of 121 patients with gastric cancer and 363 healthy individuals were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using serum samples. Results: MMP9 rs3918242 TT genotype carriers had an elevated gastric cancer risk compared to wild-type CC carriers (odds ratio=3.92, 95% confidence interval=1.28-11.99; p=0.0103). Patients with CT/TT genotypes were at higher risk of metastasis (p=0.0178) than those with CC. No correlation was found between MMP9 rs3918242 genotype and gastric cancer risk with smoking or alcohol behavior, nor Helicobacter pylori infection. No correlation was observed for MMP9 rs3918242 genotypic distributions with age, gender, or body mass index. Conclusion: Carrying a T allele for MMP9 rs3918242 may be predictive for higher gastric cancer risk, and as a predictor for higher risk of metastasis.

Key Words:
  • Gastric cancer
  • genotype
  • MMP9
  • polymorphism
  • Taiwan
  • Received May 26, 2021.
  • Revision received June 9, 2021.
  • Accepted June 10, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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The Association of MMP9 Promoter Rs3918242 Genotype With Gastric Cancer
CHUN-KAI FU, WEN-SHIN CHANG, CHIA-WEN TSAI, YUN-CHI WANG, MEI-DUE YANG, HUA-SHAI HSU, CHE-YI CHAO, CHIEN-CHIH YU, JAW-CHYUN CHEN, JEN-SHENG PEI, DA-TIAN BAU
Anticancer Research Jul 2021, 41 (7) 3309-3315; DOI: 10.21873/anticanres.15118

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The Association of MMP9 Promoter Rs3918242 Genotype With Gastric Cancer
CHUN-KAI FU, WEN-SHIN CHANG, CHIA-WEN TSAI, YUN-CHI WANG, MEI-DUE YANG, HUA-SHAI HSU, CHE-YI CHAO, CHIEN-CHIH YU, JAW-CHYUN CHEN, JEN-SHENG PEI, DA-TIAN BAU
Anticancer Research Jul 2021, 41 (7) 3309-3315; DOI: 10.21873/anticanres.15118
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Keywords

  • gastric cancer
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