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Research ArticleExperimental Studies

Heparanase Expression Is Associated With Cancer Stem Cell Features and Radioresistance in Hodgkin’s Lymphoma Cells

FABIAN M. TROSCHEL, MATTHIAS LINSENMAIER, KATRIN BORRMANN, HANS THEODOR EICH, MARTIN GÖTTE and BURKHARD GREVE
Anticancer Research July 2021, 41 (7) 3299-3308; DOI: https://doi.org/10.21873/anticanres.15117
FABIAN M. TROSCHEL
1Department of Radiation Oncology, Münster University Hospital, Münster, Germany;
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  • For correspondence: fabian.troschel@uni-muenster.de
MATTHIAS LINSENMAIER
1Department of Radiation Oncology, Münster University Hospital, Münster, Germany;
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KATRIN BORRMANN
1Department of Radiation Oncology, Münster University Hospital, Münster, Germany;
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HANS THEODOR EICH
1Department of Radiation Oncology, Münster University Hospital, Münster, Germany;
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MARTIN GÖTTE
2Department of Gynecology and Obstetrics, Münster University Hospital, Münster, Germany
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BURKHARD GREVE
1Department of Radiation Oncology, Münster University Hospital, Münster, Germany;
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Abstract

Background/aim: Heparanase (HPSE) is relevant to therapy resistance in many malignancies yet is largely unstudied in Hodgkin’s lymphoma. Here, we investigated links between HPSE, cancer stem cell (CSC) features and radioresistance in KM-H2 and L428 Hodgkin’s lymphoma cells. Materials and Methods: Firstly, HPSE expression in unsorted and sorted CSCs was assessed. Post-irradiation, HPSE and CSC-related gene expression changes were then quantified. Clonogenic ability was investigated with and without artificial changes in HPSE expression pre and post irradiation. Results: HPSE was highly expressed in L428 but barely present in KM-H2 cells. HPSE was overexpressed in sorted L428 CSCs. Irradiation induced HPSE and expression of CSC markers. High HPSE-expressing L428 cells showed higher clonogenic ability than low HPSE-expressing KM-H2 cells after irradiation. Down-regulation of HPSE in L428 cells reduced their clonogenic capability post-radiation, whilst overexpression of HPSE in KM-H2 cells increased colony formation. Conclusion: HPSE expression is associated with CSC features and contributes to radioresistance in Hodgkin’s lymphoma cells.

Key Words:
  • Heparanase
  • HPSE
  • Hodgkin’s lymphoma
  • cancer stem cells
  • radioresistance
  • Received May 25, 2021.
  • Revision received June 12, 2021.
  • Accepted June 15, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (7)
Anticancer Research
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July 2021
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Heparanase Expression Is Associated With Cancer Stem Cell Features and Radioresistance in Hodgkin’s Lymphoma Cells
FABIAN M. TROSCHEL, MATTHIAS LINSENMAIER, KATRIN BORRMANN, HANS THEODOR EICH, MARTIN GÖTTE, BURKHARD GREVE
Anticancer Research Jul 2021, 41 (7) 3299-3308; DOI: 10.21873/anticanres.15117

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Heparanase Expression Is Associated With Cancer Stem Cell Features and Radioresistance in Hodgkin’s Lymphoma Cells
FABIAN M. TROSCHEL, MATTHIAS LINSENMAIER, KATRIN BORRMANN, HANS THEODOR EICH, MARTIN GÖTTE, BURKHARD GREVE
Anticancer Research Jul 2021, 41 (7) 3299-3308; DOI: 10.21873/anticanres.15117
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Keywords

  • Heparanase
  • HPSE
  • Hodgkin’s lymphoma
  • cancer stem cells
  • radioresistance
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