Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

The INCH Trial – Induction Chemotherapy in Patients With Bulky Anal Canal Cancer: Evaluation of the Pilot Phase

FRANCESCA DE FELICE, ALESSIA FALLARINO, FRANCO IAFRATE, VERONICA MAIURI, GIOVANNI GALLONI, GIOVANNI TURRIZIANI COLONNA, RAFFAELLA DE PIETRO, GIUSEPPINA CHIARELLO, CLAUDIA MARCHETTI, NADIA BULZONETTI, DANIELA MUSIO and VINCENZO TOMBOLINI
Anticancer Research June 2021, 41 (6) 3187-3191; DOI: https://doi.org/10.21873/anticanres.15105
FRANCESCA DE FELICE
1Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: fradefelice@hotmail.it
ALESSIA FALLARINO
1Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
FRANCO IAFRATE
2Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
VERONICA MAIURI
1Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
GIOVANNI GALLONI
1Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
GIOVANNI TURRIZIANI COLONNA
1Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
RAFFAELLA DE PIETRO
1Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
GIUSEPPINA CHIARELLO
1Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CLAUDIA MARCHETTI
3Department of Woman, Child and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
NADIA BULZONETTI
1Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DANIELA MUSIO
1Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
VINCENZO TOMBOLINI
1Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Aim: To assess feasibility, complications and efficacy of induction chemotherapy followed by standard chemoradiotherapy in patients with bulky anal canal cancer. Patients and Methods: Patients with squamous cell carcinoma of the anal canal, staged bulky tumor with or without nodal involvement were prospectively enrolled. Before standard chemoradiotherapy, patients received induction chemotherapy with 3 cycles of 75 mg/m2 cisplatin and 750 mg/m2 5-fluorouracil. Patients were followed-up routinely until recurrence or death. Results: Seven patients with bulky anal canal cancer were evaluable for this pilot phase of the study. All patients had human papillomavirus-negative disease. Five completed the scheduled induction chemotherapy and all patients completed the programmed concomitant chemoradiotherapy. None had severe hematological toxicity. The majority of patients (6/7) had tumor downsizing after induction treatment. Six months after chemoradiotherapy, complete response was documented in three patients and salvage surgery was performed in two cases. With a median follow-up of 38 months (range=28-48 months), two patients are disease-free survivors. Conclusion: Induction chemotherapy has the potential to become a standard approach in patients with bulky human papillomavirus-negative anal canal cancer.

Key Words:
  • Induction chemotherapy
  • anal canal carcinoma
  • chemoradiotherapy
  • cisplatin
  • 5-FU
  • prospective study
  • Received April 7, 2021.
  • Revision received April 24, 2021.
  • Accepted April 27, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
View Full Text

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

patientACCESS

patientACCESS - Patients desiring access to articles
PreviousNext
Back to top

In this issue

Anticancer Research: 41 (6)
Anticancer Research
Vol. 41, Issue 6
June 2021
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The INCH Trial – Induction Chemotherapy in Patients With Bulky Anal Canal Cancer: Evaluation of the Pilot Phase
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
9 + 5 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
The INCH Trial – Induction Chemotherapy in Patients With Bulky Anal Canal Cancer: Evaluation of the Pilot Phase
FRANCESCA DE FELICE, ALESSIA FALLARINO, FRANCO IAFRATE, VERONICA MAIURI, GIOVANNI GALLONI, GIOVANNI TURRIZIANI COLONNA, RAFFAELLA DE PIETRO, GIUSEPPINA CHIARELLO, CLAUDIA MARCHETTI, NADIA BULZONETTI, DANIELA MUSIO, VINCENZO TOMBOLINI
Anticancer Research Jun 2021, 41 (6) 3187-3191; DOI: 10.21873/anticanres.15105

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
The INCH Trial – Induction Chemotherapy in Patients With Bulky Anal Canal Cancer: Evaluation of the Pilot Phase
FRANCESCA DE FELICE, ALESSIA FALLARINO, FRANCO IAFRATE, VERONICA MAIURI, GIOVANNI GALLONI, GIOVANNI TURRIZIANI COLONNA, RAFFAELLA DE PIETRO, GIUSEPPINA CHIARELLO, CLAUDIA MARCHETTI, NADIA BULZONETTI, DANIELA MUSIO, VINCENZO TOMBOLINI
Anticancer Research Jun 2021, 41 (6) 3187-3191; DOI: 10.21873/anticanres.15105
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Patients and Methods
    • Results
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Pelvic Recurrence After Curative Resection for Rectal Adenocarcinoma: Impact of Surgery on Survival
  • Glasgow Prognostic Score Predicts Survival and Recurrence Pattern in Patients With Hepatocellular Carcinoma After Hepatectomy
  • Small Bowel Lipomatosis: An Unusual Radiological Finding in Patients With Renal Cell Cancer on Pazopanib
Show more Clinical Studies

Similar Articles

Keywords

  • induction chemotherapy
  • anal canal carcinoma
  • chemoradiotherapy
  • cisplatin
  • 5-FU
  • Prospective study
Anticancer Research

© 2023 Anticancer Research

Powered by HighWire