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Research ArticleExperimental Studies

Proteomic Analysis of Malignant Ascites From Patients With Pancreatic Ductal Adenocarcinoma

FUMIMASA KITAMURA, TATSUNORI MIYATA, NORIO UEMURA, TOMOYUKI UCHIHARA, KATSUNORI IMAI, HIROMITSU HAYASHI, YO-ICHI YAMASHITA, KEISUKE MATSUSAKI, TAKATSUGU ISHIMOTO and HIDEO BABA
Anticancer Research June 2021, 41 (6) 2895-2900; DOI: https://doi.org/10.21873/anticanres.15071
FUMIMASA KITAMURA
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan;
2The Gastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan;
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TATSUNORI MIYATA
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan;
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NORIO UEMURA
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan;
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TOMOYUKI UCHIHARA
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan;
2The Gastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan;
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KATSUNORI IMAI
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan;
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HIROMITSU HAYASHI
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan;
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YO-ICHI YAMASHITA
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan;
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KEISUKE MATSUSAKI
3Kanamecho Hospital, Tokyo, Japan;
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TAKATSUGU ISHIMOTO
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan;
2The Gastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan;
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HIDEO BABA
1Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan;
4Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
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  • For correspondence: hdobaba@kumamoto-u.ac.jp
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Abstract

Background/Aim: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant tumor. Research using an innovative research approach is needed to identify effective biomarkers or therapeutic targets for PDAC. We aimed to identify proteins related to the peritoneal dissemination of PDAC. Materials and Methods: We performed proteomic analysis using ascites samples from patients with advanced PDAC and peritoneal dissemination and patients with liver cirrhosis (LC). Proteins specific to PDAC were identified in comparison to the findings for ascites from patients with LC as a control group. Results: In total, 336 proteins were identified in ascites from patients with PDAC. We identified 18 specific proteins in ascites from patients with advanced PDAC. Among these proteins, CD13, lymphatic vessel endothelial hyaluronan receptor 1, ficolin-3, and V-set and immunoglobulin domain containing 4 were the most frequently detected. In addition, these 18 proteins could be classified into four categories: extracellular matrix, immunity, metabolism, and others. Conclusion: The identified proteins could be informative for developing treatment strategies for patients with PDAC and peritoneal dissemination.

Key Words:
  • Biomarker
  • malignant ascites
  • pancreatic ductal adenocarcinoma
  • proteomics
  • Received April 23, 2021.
  • Revision received May 9, 2021.
  • Accepted May 11, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (6)
Anticancer Research
Vol. 41, Issue 6
June 2021
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Proteomic Analysis of Malignant Ascites From Patients With Pancreatic Ductal Adenocarcinoma
FUMIMASA KITAMURA, TATSUNORI MIYATA, NORIO UEMURA, TOMOYUKI UCHIHARA, KATSUNORI IMAI, HIROMITSU HAYASHI, YO-ICHI YAMASHITA, KEISUKE MATSUSAKI, TAKATSUGU ISHIMOTO, HIDEO BABA
Anticancer Research Jun 2021, 41 (6) 2895-2900; DOI: 10.21873/anticanres.15071

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Proteomic Analysis of Malignant Ascites From Patients With Pancreatic Ductal Adenocarcinoma
FUMIMASA KITAMURA, TATSUNORI MIYATA, NORIO UEMURA, TOMOYUKI UCHIHARA, KATSUNORI IMAI, HIROMITSU HAYASHI, YO-ICHI YAMASHITA, KEISUKE MATSUSAKI, TAKATSUGU ISHIMOTO, HIDEO BABA
Anticancer Research Jun 2021, 41 (6) 2895-2900; DOI: 10.21873/anticanres.15071
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Keywords

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