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Research ArticleClinical Studies

Elevated Postoperative Levels of Serum C-reactive Protein Are Associated With Shorter Long-term Survival After Resection of Colorectal Liver Metastases, Regardless of the Occurrence of Infectious Complications

MASATSUNE SHIBUTANI, KENJIRO KIMURA, SHINICHIRO KASHIWAGI, EN WANG, YUKI OKAZAKI, KIYOSHI MAEDA, KOSEI HIRAKAWA and MASAICHI OHIRA
Anticancer Research May 2021, 41 (5) 2605-2610; DOI: https://doi.org/10.21873/anticanres.15040
MASATSUNE SHIBUTANI
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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  • For correspondence: fbxbj429@ybb.ne.jp
KENJIRO KIMURA
2Department of Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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SHINICHIRO KASHIWAGI
3Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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EN WANG
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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YUKI OKAZAKI
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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KIYOSHI MAEDA
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
4Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka, Japan
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KOSEI HIRAKAWA
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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MASAICHI OHIRA
1Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
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Abstract

Background/Aim: Recently, elevated levels of postoperative inflammatory markers have been reported to be associated with poorer long-term survival outcomes, regardless of the occurrence of infectious complications, in gastroenterological malignancies. The aim of this study was to evaluate the association between postoperative inflammation and shorter long-term survival after resection of colorectal liver metastases. Patients and Methods: A total of 104 patients who underwent R0 resection for colorectal liver metastases were enrolled. The CRPmax levels were defined as the highest postoperative serum C-reactive protein levels during hospital stay. Results: The high-CRPmax group had a significantly lower relapse-free survival rate than the low-CRPmax group, regardless of the occurrence of infectious complications. Conclusion: In colorectal liver metastasis as well as other malignancies, elevated postoperative levels of serum C-reactive protein are associated with shorter long-term survival, regardless of the occurrence of infectious complications.

Key Words:
  • Colorectal liver metastasis
  • inflammation
  • C-reactive protein
  • prognosis
  • Received February 24, 2021.
  • Revision received April 4, 2021.
  • Accepted April 5, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (5)
Anticancer Research
Vol. 41, Issue 5
May 2021
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Elevated Postoperative Levels of Serum C-reactive Protein Are Associated With Shorter Long-term Survival After Resection of Colorectal Liver Metastases, Regardless of the Occurrence of Infectious Complications
MASATSUNE SHIBUTANI, KENJIRO KIMURA, SHINICHIRO KASHIWAGI, EN WANG, YUKI OKAZAKI, KIYOSHI MAEDA, KOSEI HIRAKAWA, MASAICHI OHIRA
Anticancer Research May 2021, 41 (5) 2605-2610; DOI: 10.21873/anticanres.15040

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Elevated Postoperative Levels of Serum C-reactive Protein Are Associated With Shorter Long-term Survival After Resection of Colorectal Liver Metastases, Regardless of the Occurrence of Infectious Complications
MASATSUNE SHIBUTANI, KENJIRO KIMURA, SHINICHIRO KASHIWAGI, EN WANG, YUKI OKAZAKI, KIYOSHI MAEDA, KOSEI HIRAKAWA, MASAICHI OHIRA
Anticancer Research May 2021, 41 (5) 2605-2610; DOI: 10.21873/anticanres.15040
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