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Research ArticleClinical Studies

Comparison of Chemotherapeutic Regimens Frequently Used in Metastatic Non-squamous NSCLC Treatment

DANIEL KREJCI, PETR OPALKA, JANA KREJCI, MILADA ZEMANOVA, PETRA ZEMANOVA, JURAJ KULTAN, ONDREJ FISCHER, JANA SKRICKOVA, MONIKA BRATOVA, MARKETA CERNOVSKA, MICHAL HRNCIARIK, HELENA COUPKOVA, KAROLINA HURDALKOVA, MAGDA BARINOVA, LEONA KOUBKOVA, DANIEL DOLEZAL, MARTIN SAFANDA, MILOS PESEK and MARTIN SVATON
Anticancer Research May 2021, 41 (5) 2597-2603; DOI: https://doi.org/10.21873/anticanres.15039
DANIEL KREJCI
1Department of Pneumology, Third Faculty of Medicine and Bulovka University Hospital, Charles University, Prague, Czech Republic;
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PETR OPALKA
1Department of Pneumology, Third Faculty of Medicine and Bulovka University Hospital, Charles University, Prague, Czech Republic;
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JANA KREJCI
1Department of Pneumology, Third Faculty of Medicine and Bulovka University Hospital, Charles University, Prague, Czech Republic;
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MILADA ZEMANOVA
2Department of Oncology, First Faculty of Medicine in Prague, Charles University, Prague, Czech Republic;
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PETRA ZEMANOVA
2Department of Oncology, First Faculty of Medicine in Prague, Charles University, Prague, Czech Republic;
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JURAJ KULTAN
3Department of Respiratory Medicine, Faculty of Medicine and Olomouc University Hospital, Palacky University, Olomouc, Czech Republic;
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ONDREJ FISCHER
3Department of Respiratory Medicine, Faculty of Medicine and Olomouc University Hospital, Palacky University, Olomouc, Czech Republic;
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JANA SKRICKOVA
4Department of Respiratory Diseases and TB, Faculty of Medicine and University Hospital Brno, Masaryk University Brno, Brno, Czech Republic;
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MONIKA BRATOVA
4Department of Respiratory Diseases and TB, Faculty of Medicine and University Hospital Brno, Masaryk University Brno, Brno, Czech Republic;
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MARKETA CERNOVSKA
5Department of Respiratory Medicine, First Faculty of Medicine and Thomayer University Hospital, Charles University, Prague, Czech Republic;
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MICHAL HRNCIARIK
6Department of Pneumology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic;
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HELENA COUPKOVA
7Department of Comprehensive Oncology, Masaryk Institute of Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic;
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KAROLINA HURDALKOVA
8Institute of Biostatistics and Analyses Ltd., Brno, Czech Republic;
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MAGDA BARINOVA
8Institute of Biostatistics and Analyses Ltd., Brno, Czech Republic;
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LEONA KOUBKOVA
9Department of Pneumology, Second Faculty of Medicine and Motol University Hospital, Charles University, Prague, Czech Republic;
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DANIEL DOLEZAL
10Department of Pneumology, Masaryk Hospital Ústí nad Labem, Ústí nad Labem, Czech Republic;
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MARTIN SAFANDA
11Department of Clinical Oncology, Na Homolce Hospital, Prague, Czech Republic;
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MILOS PESEK
12Department of Pneumology and Phthisiology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
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MARTIN SVATON
12Department of Pneumology and Phthisiology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
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  • For correspondence: svatonm@fnplzen.cz
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Abstract

Background/Aim: Platinum-based chemotherapy with pemetrexed or paclitaxel/bevacizumab are regimens used in combination with checkpoint inhibitors in non-squamous non-small cell lung cancer (NSCLC) treatment. We conducted a real-world study to compare the outcomes of these chemotherapeutic regimens. Patients and Methods: We investigated 1,534 patients with advanced non-squamous NSCLC treated with platin/pemetrexed (n=1212) or platin/paclitaxel/bevacizumab (n=322) in 9 cancer centres in the Czech Republic. Results: The regimen containing platin/paclitaxel/bevacizumab showed significantly better overall response rate (ORR) compared to the platin/pemetrexed [40.8% vs. 32.7% (p=0.008)] in the overall population and [55.0% vs. 38.8% (p=0.002)] in the Eastern Cooperative Oncology Group performance status 0 group. There was no significant improvement in progression-free survival (PFS) and overall survival (OS) in either of these two groups of patients. Conclusion: In our real-world data analysis, patients treated with platin/paclitaxel/bevacizumab had better overall response rate (ORR), but not PFS or OS. Thus, both treatment regimens are similarly effective. Their selection should therefore be based on the potential side effects.

Key Words:
  • NSCLC
  • chemotherapy
  • real-world data
  • bevacizumab
  • pemetrexed
  • Received March 31, 2021.
  • Revision received April 11, 2021.
  • Accepted April 12, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (5)
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Comparison of Chemotherapeutic Regimens Frequently Used in Metastatic Non-squamous NSCLC Treatment
DANIEL KREJCI, PETR OPALKA, JANA KREJCI, MILADA ZEMANOVA, PETRA ZEMANOVA, JURAJ KULTAN, ONDREJ FISCHER, JANA SKRICKOVA, MONIKA BRATOVA, MARKETA CERNOVSKA, MICHAL HRNCIARIK, HELENA COUPKOVA, KAROLINA HURDALKOVA, MAGDA BARINOVA, LEONA KOUBKOVA, DANIEL DOLEZAL, MARTIN SAFANDA, MILOS PESEK, MARTIN SVATON
Anticancer Research May 2021, 41 (5) 2597-2603; DOI: 10.21873/anticanres.15039

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Comparison of Chemotherapeutic Regimens Frequently Used in Metastatic Non-squamous NSCLC Treatment
DANIEL KREJCI, PETR OPALKA, JANA KREJCI, MILADA ZEMANOVA, PETRA ZEMANOVA, JURAJ KULTAN, ONDREJ FISCHER, JANA SKRICKOVA, MONIKA BRATOVA, MARKETA CERNOVSKA, MICHAL HRNCIARIK, HELENA COUPKOVA, KAROLINA HURDALKOVA, MAGDA BARINOVA, LEONA KOUBKOVA, DANIEL DOLEZAL, MARTIN SAFANDA, MILOS PESEK, MARTIN SVATON
Anticancer Research May 2021, 41 (5) 2597-2603; DOI: 10.21873/anticanres.15039
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