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Research ArticleClinical Studies

Cutaneous Lesion of the Nose as Initial Presentation of Esophageal Adenocarcinoma

AARON HAAG, DEANNA HUFFMAN, CHELSEA PETERSON, KARTHIK SHANKAR, LYNNA ALNIMER, YAZAN SAMHOURI and LARISA GREENBERG
Anticancer Research May 2021, 41 (5) 2485-2488; DOI: https://doi.org/10.21873/anticanres.15025
AARON HAAG
1Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, U.S.A.;
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  • For correspondence: Aaron.Haag@ahn.org
DEANNA HUFFMAN
1Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, U.S.A.;
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CHELSEA PETERSON
1Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, U.S.A.;
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KARTHIK SHANKAR
1Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, U.S.A.;
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LYNNA ALNIMER
2Department of Internal Medicine, Ascension Providence Hospital, Michigan State University, College of Human Medicine, Southfield, MI, U.S.A.;
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YAZAN SAMHOURI
3Division of Medical Oncology, Allegheny General Hospital, Pittsburgh, PA, U.S.A.
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LARISA GREENBERG
3Division of Medical Oncology, Allegheny General Hospital, Pittsburgh, PA, U.S.A.
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Abstract

Background/Aim: Cutaneous manifestations of disease are exceedingly rare and commonly overlooked in clinical practice. Allergies or contact dermatitis, autoimmune disease or skin cancer are the most common conditions typically associated with skin lesions. Rarely, cutaneous lesions may be the first sign of internal malignancy, or even resemble recurrent disease in those with history of cancer. Case Report: Herein, we report a case of an otherwise healthy male who presented to his primary care provider (PCP) with a skin lesion misdiagnosed as a furuncle, which eventually led to diagnosis of metastatic esophageal cancer. The patient was a 64-year-old male, presenting with a fungating lesion on the tip of his nose which was biopsied, confirming adenocarcinoma likely from a gastrointestinal source. Staging imaging showed extensive lung, liver, and boney metastatic disease. He was initially treated with chemotherapy and trastuzumab. Conclusion: Cutaneous lesions are a rare presenting sign of malignancy, but rapidly growing lesions should be evaluated for possible metastatic disease.

Key Words:
  • Adenocarcinoma
  • esophageal cancer
  • chemotherapy
  • cutaneous lesion
  • metastatic disease
  • Received March 9, 2021.
  • Revision received March 22, 2021.
  • Accepted April 6, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (5)
Anticancer Research
Vol. 41, Issue 5
May 2021
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Cutaneous Lesion of the Nose as Initial Presentation of Esophageal Adenocarcinoma
AARON HAAG, DEANNA HUFFMAN, CHELSEA PETERSON, KARTHIK SHANKAR, LYNNA ALNIMER, YAZAN SAMHOURI, LARISA GREENBERG
Anticancer Research May 2021, 41 (5) 2485-2488; DOI: 10.21873/anticanres.15025

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Cutaneous Lesion of the Nose as Initial Presentation of Esophageal Adenocarcinoma
AARON HAAG, DEANNA HUFFMAN, CHELSEA PETERSON, KARTHIK SHANKAR, LYNNA ALNIMER, YAZAN SAMHOURI, LARISA GREENBERG
Anticancer Research May 2021, 41 (5) 2485-2488; DOI: 10.21873/anticanres.15025
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Keywords

  • adenocarcinoma
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