Table of Contents

Clinical Studies

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  Pretreatment MRI in Primary Rectal Cancer as a Predictor for Oncological Outcomes After Surgery for Local Recurrence

  ANDERS H. ELLIOT, BARWAR N. OTHMAN, CHIKAKO SUZUKI, LENNART BLOMQVIST, ANNA MARTLING, HEMMING JOHANSSON, BENGT GLIMELIUS, PER J. NILSSON and HENRIK IVERSEN

  Anticancer Research May 2021, 41 (5) 2459-2465; DOI: https://doi.org/10.21873/anticanres.15021
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  Adaptive Radiation Therapy for Intact Thymoma: An Illustrative Report

  NEIL CHEVLI, ROSS E. BLAND, ANDREW M. FARACH, RAMIRO PINO, THOMAS MATHEWS, EKENE I. OKOYE, SHANDA BLACKMON, E. BRIAN BUTLER and BIN S. TEH

  Anticancer Research May 2021, 41 (5) 2467-2471; DOI: https://doi.org/10.21873/anticanres.15022
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  What Is the Clinical Impact of Sending Tissue for Histopathology During Surgery for Known, Diffuse Metastatic Disease to Bone?

  CHARLES A. GUSHO and ALAN T. BLANK

  Anticancer Research May 2021, 41 (5) 2473-2476; DOI: https://doi.org/10.21873/anticanres.15023
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  Diagnostic Role of PET/CT Tracers in the Detection and Localization of Tumours Responsible for Ectopic Cushing’s Syndrome

  LUCIA ZISSER, OANA C. KULTERER, BIANCA ITARIU, BARBARA FUEGER, MICHAEL WEBER, PETER MAZAL, CHRYSOULA VRAKA, VERENA PICHLER, ALEXANDRA KAUTZKY-WILLER, MARCUS HACKER, GEORGIOS KARANIKAS and SAZAN RASUL

  Anticancer Research May 2021, 41 (5) 2477-2484; DOI: https://doi.org/10.21873/anticanres.15024
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  Cutaneous Lesion of the Nose as Initial Presentation of Esophageal Adenocarcinoma

  AARON HAAG, DEANNA HUFFMAN, CHELSEA PETERSON, KARTHIK SHANKAR, LYNNA ALNIMER, YAZAN SAMHOURI and LARISA GREENBERG

  Anticancer Research May 2021, 41 (5) 2485-2488; DOI: https://doi.org/10.21873/anticanres.15025
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  Sleep Disorders in Patients With Breast Cancer Prior to a Course of Radiotherapy – Prevalence and Risk Factors

  DIRK RADES, CARLOS A. NARVAEZ, LIESA DZIGGEL, SOEREN TVILSTED and TROELS W. KJAER

  Anticancer Research May 2021, 41 (5) 2489-2494; DOI: https://doi.org/10.21873/anticanres.15026
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  Karnofsky Performance Score – An Independent Prognostic Factor of Survival After Palliative Irradiation for Sino-nasal Cancer

  DIRK RADES, CHRISTIAN STAACKMANN and STEVEN E. SCHILD

  Anticancer Research May 2021, 41 (5) 2495-2499; DOI: https://doi.org/10.21873/anticanres.15027
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  PD-L1 Expression Status Predicting Survival in Pulmonary Pleomorphic Carcinoma

  KAKERU HISAKANE, MASAHIRO SEIKE, TEPPEI SUGANO, KUNIKO MATSUDA, SHINOBU KUNUGI, SHINJI NAKAMICHI, MASARU MATSUMOTO, AKIHIKO MIYANAGA, RINTARO NORO, YUJI MINEGISHI, KAORU KUBOTA and AKIHIKO GEMMA

  Anticancer Research May 2021, 41 (5) 2501-2509; DOI: https://doi.org/10.21873/anticanres.15028
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  Relevance of CYP3A5 Expression on the Clinical Outcome of Patients With Renal Cell Carcinoma

  JUN MATSUMOTO, YUMI KOTERA, SHOGO WATARI, KOICHI TAKEUCHI, HIDEO UEKI, TOSHIHIRO KOYAMA, KOICHIRO WADA, MASACHIKA FUJIYOSHI, YASUTOMO NASU and NORITAKA ARIYOSHI

  Anticancer Research May 2021, 41 (5) 2511-2521; DOI: https://doi.org/10.21873/anticanres.15029
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  Comparison of Physician-recorded Toxicities and Patient-reported Outcomes of Five Different Radiotherapy Methods for Prostate Cancer

  MAKOTO ITO, KAZUMA SASAMURA, YUUKI TAKASE, TADAYUKI KOTSUMA, YUKIHIKO OSHIMA, YOSHITAKA MINAMI, JUNJI SUZUKI, EIICHI TANAKA, WATARU OHASHI, MASAHIKO OGUCHI, TAKAHITO OKUDA, KOJIRO SUZUKI and YASUO YOSHIOKA

  Anticancer Research May 2021, 41 (5) 2523-2531; DOI: https://doi.org/10.21873/anticanres.15030
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  Impact of Inferior Mesenteric Artery Lymph Node Metastasis on the Prognosis of Left-sided Colorectal Cancer

  KAZUYA TAKABATAKE, TOMOHIRO ARITA, MASAYOSHI NAKANISHI, YOSHIAKI KURIU, YASUTOSHI MURAYAMA, HIROKI SHIMIZU, MICHIHIRO KUDOU, JUN KIUCHI, TOSHIYUKI KOSUGA, HIROTAKA KONISHI, RYO MORIMURA, ATSUSHI SHIOZAKI, HISASHI IKOMA, TAKESHI KUBOTA, HITOSHI FUJIWARA, KAZUMA OKAMOTO and EIGO OTSUJI

  Anticancer Research May 2021, 41 (5) 2533-2542; DOI: https://doi.org/10.21873/anticanres.15031
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  Cytoplasmic-only Expression of Maspin Predicts Unfavorable Prognosis in Patients With Pancreatic Ductal Adenocarcinoma

  EI UCHINAKA, TOMOHIKO SAKABE, TAKEHIKO HANAKI, NARUO TOKUYASU, TERUHISA SAKAMOTO, SOICHIRO HONJO, YOSHIYUKI FUJIWARA and YOSHIHISA UMEKITA

  Anticancer Research May 2021, 41 (5) 2543-2552; DOI: https://doi.org/10.21873/anticanres.15032
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  Regorafenib-to-trifluridine/tipiracil Versus the Reverse Sequence for Refractory Metastatic Colorectal Cancer Patients: A Multicenter Retrospective Real-life Experience

  CARLO SIGNORELLI, DONATELLO GEMMA, ROBERTA GRANDE, SALVATORE DE MARCO, ROSA SALTARELLI, MARIA GRAZIA MORANDI, GIAN PAOLO SPINELLI, FEDERICA ZORATTO, ISABELLA SPERDUTI, MARIO GIOVANNI CHILELLI, ANNA CERIBELLI and ENZO MARIA RUGGERI

  Anticancer Research May 2021, 41 (5) 2553-2561; DOI: https://doi.org/10.21873/anticanres.15033
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  Prognosis of Patients With Interstitial Lung Disease Induced by Different Pharmacological Types of Anticancer Drugs

  KOHEI IWASHITA, TOMOHIRO MIZUNO, SATOMI KUMAZAWA, KAZUYOSHI IMAIZUMI and SHIGEKI YAMADA

  Anticancer Research May 2021, 41 (5) 2563-2568; DOI: https://doi.org/10.21873/anticanres.15034
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  Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs

  TAKAFUMI YAMAMOTO, NORIHIRO IMAI, KENTA YAMAMOTO, TAKANORI ITO, YOJI ISHIZU, TAKASHI HONDA, SHUICHI OKAMOTO, TAKESHI KANEMATSU, NOBUAKI SUZUKI, TADASHI MATSUSHITA, MASATOSHI ISHIGAMI and MITSUHIRO FUJISHIRO

  Anticancer Research May 2021, 41 (5) 2569-2573; DOI: https://doi.org/10.21873/anticanres.15035
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  Effective Control of Brain Metastases Irrespective of Distance from Isocenter in Single-isocenter Multitarget Stereotactic Radiosurgery

  KEN AOKI, YUKIHIRO NAGATANI, KAZUO NOMA, TAKUYA TSUGAWA, NAOAKI KONO, YUKAKO KIDA, NAOKI HARADA, YOSHIHIDE TANOUE and YOSHIYUKI WATANABE

  Anticancer Research May 2021, 41 (5) 2575-2581; DOI: https://doi.org/10.21873/anticanres.15036
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  Brainstem Infiltration Predicts Survival in Patients With High-grade Gliomas Treated With Chemoradiotherapy

  SHIMPEI ANAMI, JUNYA FUKAI, MIZUKI HAMA, AZUSA AWAYA, TAKAYA INAGAKI, TAKAHIRO CHIBA, YASUTAKA NODA, YONEHIRO KANEMURA, NAOYUKI NAKAO and TETSUO SONOMURA

  Anticancer Research May 2021, 41 (5) 2583-2589; DOI: https://doi.org/10.21873/anticanres.15037
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  Switching from Intravenous to Oral Tacrolimus Reduces its Blood Concentration in Paediatric Cancer Patients

  HARUKI UJIIE, SATORU NIHEI, NAOYUKI NISHIYA, SHINPEI GOTO, YOSHIKO ASAKURA, SHOKO MIURA, DAISHI HIRAI, MIKIYA ENDO, TATSUO OYAKE, SHIGEKI ITO, TAKESHI CHIBA and KENZO KUDO

  Anticancer Research May 2021, 41 (5) 2591-2596; DOI: https://doi.org/10.21873/anticanres.15038
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  Comparison of Chemotherapeutic Regimens Frequently Used in Metastatic Non-squamous NSCLC Treatment

  DANIEL KREJCI, PETR OPALKA, JANA KREJCI, MILADA ZEMANOVA, PETRA ZEMANOVA, JURAJ KULTAN, ONDREJ FISCHER, JANA SKRICKOVA, MONIKA BRATOVA, MARKETA CERNOVSKA, MICHAL HRNCIARIK, HELENA COUPKOVA, KAROLINA HURDALKOVA, MAGDA BARINOVA, LEONA KOUBKOVA, DANIEL DOLEZAL, MARTIN SAFANDA, MILOS PESEK and MARTIN SVATON

  Anticancer Research May 2021, 41 (5) 2597-2603; DOI: https://doi.org/10.21873/anticanres.15039
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  Elevated Postoperative Levels of Serum C-reactive Protein Are Associated With Shorter Long-term Survival After Resection of Colorectal Liver Metastases, Regardless of the Occurrence of Infectious Complications

  MASATSUNE SHIBUTANI, KENJIRO KIMURA, SHINICHIRO KASHIWAGI, EN WANG, YUKI OKAZAKI, KIYOSHI MAEDA, KOSEI HIRAKAWA and MASAICHI OHIRA

  Anticancer Research May 2021, 41 (5) 2605-2610; DOI: https://doi.org/10.21873/anticanres.15040
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  Laparoscopic Surgery Is Acceptable for Elderly Patients With Colorectal Cancer: A Propensity Score-matched Study

  MAKOTO TAKAHASHI, KAZUHIRO SAKAMOTO, TAKAHIRO IRIE, SHINGO KAWANO, KIICHI SUGIMOTO, YUTAKA KOJIMA, SHUKO NOJIRI, ATSUSHI OKUZAWA and YUICHI TOMIKI

  Anticancer Research May 2021, 41 (5) 2611-2615; DOI: https://doi.org/10.21873/anticanres.15041
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  Potential Benefits of Minimally Invasive Laparoscopy in Reducing Local Recurrence After Surgery for Low Rectal Cancer

  MASAKATSU NUMATA, HIROSHI TAMAGAWA, KEISUKE KAZAMA, YOSUKE ATSUMI, KENTA IGUCHI, SHO SAWAZAKI, TORU AOYAMA, SUMITO SATO, NOBUHIRO SUGANO, TENI GODAI, AKIO HIGUCHI, YUSUKE SAIGUSA, HIROYUKI SAEKI, TAKANOBU YAMADA, TAKASHI OSHIMA, MANABU SHIOZAWA, NORIO YUKAWA and YASUSHI RINO

  Anticancer Research May 2021, 41 (5) 2617-2623; DOI: https://doi.org/10.21873/anticanres.15042
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  Yttrium-90 Radioembolization for Hepatocellular Carcinoma: Virtual Tumor Absorbed Dose as a Predictor of Complete Response

  HYO-CHEOL KIM, JIN WOO CHOI, MYUNGSU LEE, YOON JUN KIM, JIN CHUL PAENG and JIN WOOK CHUNG

  Anticancer Research May 2021, 41 (5) 2625-2635; DOI: https://doi.org/10.21873/anticanres.15043
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  Heart Rate Variability as a Non-invasive Objective Parameter for Predicting the Occurrence of Chemotherapy-induced Peripheral Neuropathy in Patients With Gastrointestinal Cancer

  AELEE JANG and YOUNG MI SEOL

  Anticancer Research May 2021, 41 (5) 2637-2645; DOI: https://doi.org/10.21873/anticanres.15044
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  Outcome of Surgical Resection and Chemotherapy Versus Chemotherapy Alone for the Treatment of Isolated Primary Adrenal Lymphoma: A Retrospective Cohort Study of 16 Consecutive Patients

  GIULIO ILLUMINATI, PRISCILLA NARDI, CHIARA FRATINI, ROCCO PASQUA, CARLA GIORDANO, MARCO GIROLAMI and FABIO CARBONI

  Anticancer Research May 2021, 41 (5) 2647-2652; DOI: https://doi.org/10.21873/anticanres.15045
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  ERCC1 Is a Predictive Biomarker for Non-small Cell Lung Cancer But Is Antibody-dependent

  TAMIO OKIMOTO, YUKARI TSUBATA, RYOSUKE TANINO, MIKA NAKAO, TAKAMASA HOTTA, MEGUMI HAMAGUCHI, SHUNICHI HAMAGUCHI, ASUKA ARAKI and TAKESHI ISOBE

  Anticancer Research May 2021, 41 (5) 2653-2660; DOI: https://doi.org/10.21873/anticanres.15046
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  Prognostic Significance of EGFR Gene Mutation in Patients With EGFR Mutated Non-small Cell Lung Cancer Who Received Best Supportive Care Alone

  TAKESHI MASUDA, YU WAKABAYASHI, TAKU NAKASHIMA, YOSHIFUMI NISHIMURA, KIYOFUMI SHIMOJI, KAKUHIRO YAMAGUCHI, SHINJIRO SAKAMOTO, YASUSHI HORIMASU, SHINTARO MIYAMOTO, TADASHI SENOO, HIROSHI IWAMOTO, SHINICHIRO OHSHIMO, KAZUNORI FUJITAKA, HIRONOBU HAMADA and NOBORU HATTORI

  Anticancer Research May 2021, 41 (5) 2661-2667; DOI: https://doi.org/10.21873/anticanres.15047
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  Clinicopathological Features of Growth Hormone-producing Pituitary Adenomas and Correlation With Preoperative Laboratory Findings

  IULIA FLORENTINA BURCEA, VALERIA NICOLETA NĂSTASE, ANCA MARIA CÎMPEAN, AMALIA RALUCA CEAUȘU, IONELA BACIU, CRISTINA CĂPĂȚÎNĂ, ROXANA DUSCEAC, SIMONA GĂLOIU, DAN NICULESCU, ȘERBAN RADIAN, RALUCA TRIFĂNESCU, ANDA DUMITRAȘCU, LAURENȚIU CĂTĂLIN COCOȘILĂ, MARIUS RAICA and CĂTĂLINA POIANĂ

  Anticancer Research May 2021, 41 (5) 2669-2680; DOI: https://doi.org/10.21873/anticanres.15048
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  Postoperative Survival in Colitis-associated Colorectal Cancer With Ulcerative Colitis in Japan: A Multicenter Analysis

  AKIRA SUGITA, HIROKI IKEUCHI, YUUJI FUNAYAMA, KITARO FUTAMI, TSUNEO IIAI, MICHIO ITABASHI and YASUO SUZUKI

  Anticancer Research May 2021, 41 (5) 2681-2688; DOI: https://doi.org/10.21873/anticanres.15049
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  Advanced Stages and Increased Need for Adjuvant Treatments in Breast Cancer Patients: The Effect of the One-year COVID-19 Pandemic

  GIANLUCA VANNI, MARCO PELLICCIARO, MARCO MATERAZZO, DOMIZIANA PEDINI, ILARIA PORTARENA, CHIARA BUONOMO, TOMMASO PERRETTA, STEFANO RIZZA, CHIARA ADRIANA PISTOLESE and ORESTE CLAUDIO BUONOMO

  Anticancer Research May 2021, 41 (5) 2689-2696; DOI: https://doi.org/10.21873/anticanres.15050
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  Clinical Outcomes Among Major Breast Cancer Subtypes After Neoadjuvant Chemotherapy: Impact on Breast Cancer Recurrence and Survival

  PAOLO ORSARIA, ANTONELLA GRASSO, EDY IPPOLITO, FRANCESCO PANTANO, MATTEO SAMMARRA, CARLO ALTOMARE, BARBARA CAGLI, FABIO COSTA, GIUSEPPE PERRONE, GEORGETA SOPONARU, LORENZA CAGGIATI, GIANLUCA VANNI, ORESTE CLAUDIO BUONOMO and VITTORIO ALTOMARE

  Anticancer Research May 2021, 41 (5) 2697-2709; DOI: https://doi.org/10.21873/anticanres.15051
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  Alpha-fetoprotein for Gastric Cancer Staging: An Essential or Redundant Tumor Marker?

  CHUN-YI TSAI, KENG-HAO LIU, CHENG-TANG CHIU, SHUN-WEN HSUEH, CHIA-YEN HUNG, JUN-TE HSU, NGAN-MING TSANG, YU-SHIN HUNG and WEN-CHI CHOU

  Anticancer Research May 2021, 41 (5) 2711-2718; DOI: https://doi.org/10.21873/anticanres.15052
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  Dedifferentiated Mesonephric-like Adenocarcinoma of the Uterine Corpus

  SANGJOON CHOI, KIYONG NA, SO-WOON KIM and HYUN-SOO KIM

  Anticancer Research May 2021, 41 (5) 2719-2726; DOI: https://doi.org/10.21873/anticanres.15053
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  Hepatic Inflammatory Pseudotumor Mimicking Malignant Tumor With Rare Onset of Intra-abdominal Hemorrhage

  KENSUKE YAMAMURA, TORU BEPPU, ERI ODA, NOBUTAKA SATO, HIDEAKI YUKI, TOSHIHIKO MOTOHARA, HIDEAKI MIYAMOTO, SHUNICHI MIYAMURA, KOJI ONISHI, YOSHIHIKO KOMOHARA and SHINICHI AKAHOSHI

  Anticancer Research May 2021, 41 (5) 2727-2732; DOI: https://doi.org/10.21873/anticanres.15054