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Research ArticleClinical Studies

PBK Expression Is Associated With Prognosis of Patients With Oral Squamous Cell Carcinoma Treated With Radiotherapy: A Retrospective Study

WAN-NIEN YU, HENG-FU LIN, YI LEE, WEI-CHUNG SHIA, WEN-WEI SUNG, CHUNG-MIN YEH and YUEH-MIN LIN
Anticancer Research April 2021, 41 (4) 2177-2182; DOI: https://doi.org/10.21873/anticanres.14991
WAN-NIEN YU
1Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.;
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HENG-FU LIN
1Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.;
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YI LEE
2School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.;
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WEI-CHUNG SHIA
3Cancer Research Center, Department of Research, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.;
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WEN-WEI SUNG
2School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.;
4Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.;
5Department of Urology, Chung Shan Medical University Hospital, Taichung, Taiwan, R.O.C.;
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CHUNG-MIN YEH
6Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.;
7Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan, R.O.C.
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YUEH-MIN LIN
2School of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.;
6Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.;
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  • For correspondence: 93668@cch.org.tw
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Abstract

Background/Aim: To investigate the impact of PDZ-binding kinase (PBK) on the clinical outcome of patients with oral squamous cell carcinoma (OSCC) who received radiotherapy. Patients and Methods: PBK immunoreactivity of cancer specimens obtained from 179 patients with primary OSCC was analyzed by immunohistochemistry. Results: High PBK expression in tumor cells tended to be associated with advanced N-stage. The 5-year survival rate was greater for patients with high total PBK expression than in those with low PBK expression. After adjustment, high PBK remained associated with a favorable outcome. In subgroups according to tumor stage, the prognostic role was significant in patients with stage III/IV rather than those with stage I/II disease. Conclusion: We suggest that PBK expression should be used as an independent prognostic marker for patients with OSCC treated with radiotherapy, especially for those with advanced-stage disease.

Key Words:
  • PBK
  • PDZ binding kinase
  • prognosis
  • oral cancer
  • radiotherapy
  • Received February 22, 2021.
  • Revision received March 5, 2021.
  • Accepted March 10, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (4)
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PBK Expression Is Associated With Prognosis of Patients With Oral Squamous Cell Carcinoma Treated With Radiotherapy: A Retrospective Study
WAN-NIEN YU, HENG-FU LIN, YI LEE, WEI-CHUNG SHIA, WEN-WEI SUNG, CHUNG-MIN YEH, YUEH-MIN LIN
Anticancer Research Apr 2021, 41 (4) 2177-2182; DOI: 10.21873/anticanres.14991

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PBK Expression Is Associated With Prognosis of Patients With Oral Squamous Cell Carcinoma Treated With Radiotherapy: A Retrospective Study
WAN-NIEN YU, HENG-FU LIN, YI LEE, WEI-CHUNG SHIA, WEN-WEI SUNG, CHUNG-MIN YEH, YUEH-MIN LIN
Anticancer Research Apr 2021, 41 (4) 2177-2182; DOI: 10.21873/anticanres.14991
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Keywords

  • PBK
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