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Research ArticleClinical Studies

Breast Textured Implants Determine Early T-helper Impairment: BIAL2.20 Study

GIANLUCA VANNI, MARCO MATERAZZO, MARCO PELLICCIARO, SADRI AMIR, FEDERICO TACCONI, VINCENZO AMBROGI and ORESTE CLAUDIO BUONOMO
Anticancer Research April 2021, 41 (4) 2123-2132; DOI: https://doi.org/10.21873/anticanres.14984
GIANLUCA VANNI
1Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy;
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MARCO MATERAZZO
1Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy;
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  • For correspondence: mrcmaterazzo@gmail.com
MARCO PELLICCIARO
1Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy;
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SADRI AMIR
2Plastic Surgery, Great Ormond Street Hospital, London, U.K.;
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FEDERICO TACCONI
3Division of Thoracic Surgery, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy
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VINCENZO AMBROGI
3Division of Thoracic Surgery, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy
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ORESTE CLAUDIO BUONOMO
1Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy;
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Abstract

Background/Aim: Surgical stress has been correlated with higher rate of postoperative complications. Breast implants’ surfaces (textured or smooth) represent an immunological stimulus. Our prospective study (BIAL2.20) evaluated post-operative leukocytes response at baseline and postoperative day (POD) 1 and 2 after implant-based breast reconstruction. Patients and Methods: Between January and July 2020, 41 patients underwent reconstruction with textured (n=23) or smooth (n=18) implants. A full blood count and lymphocyte subsets were collected before surgery, on POD1 and POD2. Data were evaluated as difference and relative difference from baseline by two-way analysis of variance test (2-way-ANOVA). Mann-Whitney U-test was performed at each POD, whenever between-group 2-way-ANOVA reached statistical significance. Results: Within-group-analysis showed statistically significant total leukocytosis in both groups. Within-group-analysis of lymphocytes subsets demonstrated statistically significant lymphopenia in the textured group for T-lymphocytes, and T-helper cells. Between-group-analysis showed statistically significant lymphopenia in T-helper subsets in the textured group at POD1 and POD2, when compared with the smooth group. Conclusion: Textured implants demonstrated a statistically significant impairment of T-helper trend during POD1 and POD2 when compared to smooth implants by between-group 2-way-ANOVA.

Key Words:
  • Breast cancer
  • breast reconstruction
  • breast implant
  • immune function
  • immunological
  • surgery
  • Macrotextured implant
  • lymphocytes
  • leukocytes
  • white blood cell
  • Received February 9, 2021.
  • Revision received February 23, 2021.
  • Accepted February 24, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (4)
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April 2021
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Breast Textured Implants Determine Early T-helper Impairment: BIAL2.20 Study
GIANLUCA VANNI, MARCO MATERAZZO, MARCO PELLICCIARO, SADRI AMIR, FEDERICO TACCONI, VINCENZO AMBROGI, ORESTE CLAUDIO BUONOMO
Anticancer Research Apr 2021, 41 (4) 2123-2132; DOI: 10.21873/anticanres.14984

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Breast Textured Implants Determine Early T-helper Impairment: BIAL2.20 Study
GIANLUCA VANNI, MARCO MATERAZZO, MARCO PELLICCIARO, SADRI AMIR, FEDERICO TACCONI, VINCENZO AMBROGI, ORESTE CLAUDIO BUONOMO
Anticancer Research Apr 2021, 41 (4) 2123-2132; DOI: 10.21873/anticanres.14984
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Keywords

  • Breast cancer
  • Breast reconstruction
  • breast implant
  • immune function
  • immunological
  • surgery
  • Macrotextured implant
  • lymphocytes
  • leukocytes
  • white blood cell
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