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Research ArticleClinical Studies

Clinical Significance of Stanniocalcin2 mRNA Expression in Patients With Colorectal Cancer

TAKUO WATANABE, MANABU SHIOZAWA, YAYOI KIMURA, YUKIHIKO HIROSHIMA, ITARU HASHIMOTO, KEISUKE KOMORI, HAYATO WATANABE, KAZUKI KANO, HIROHITO FUJIKAWA, TORU AOYAMA, MASAKATSU NUMATA, TAKANOBU YAMADA, HIROSHI TAMAGAWA, TAKASHI OGATA, NORIO YUKAWA, SOICHIRO MORINAGA, YASUSHI RINO, MUNETAKA MASUDA, YOHEI MIYAGI and TAKASHI OSHIMA
Anticancer Research April 2021, 41 (4) 2117-2122; DOI: https://doi.org/10.21873/anticanres.14983
TAKUO WATANABE
1Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan;
2Department of Surgery, Yokohama City University, Yokohama, Japan;
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MANABU SHIOZAWA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan;
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YAYOI KIMURA
3Advanced Medical Research Centre, Yokohama City University, Yokohama, Japan;
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YUKIHIKO HIROSHIMA
4Kanagawa Cancer Centre Research Institute, Yokohama, Japan
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ITARU HASHIMOTO
2Department of Surgery, Yokohama City University, Yokohama, Japan;
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KEISUKE KOMORI
1Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan;
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HAYATO WATANABE
1Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan;
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KAZUKI KANO
1Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan;
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HIROHITO FUJIKAWA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan;
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TORU AOYAMA
2Department of Surgery, Yokohama City University, Yokohama, Japan;
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MASAKATSU NUMATA
2Department of Surgery, Yokohama City University, Yokohama, Japan;
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TAKANOBU YAMADA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan;
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HIROSHI TAMAGAWA
2Department of Surgery, Yokohama City University, Yokohama, Japan;
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TAKASHI OGATA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan;
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NORIO YUKAWA
2Department of Surgery, Yokohama City University, Yokohama, Japan;
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SOICHIRO MORINAGA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan;
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YASUSHI RINO
2Department of Surgery, Yokohama City University, Yokohama, Japan;
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MUNETAKA MASUDA
2Department of Surgery, Yokohama City University, Yokohama, Japan;
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YOHEI MIYAGI
4Kanagawa Cancer Centre Research Institute, Yokohama, Japan
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TAKASHI OSHIMA
1Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan;
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  • For correspondence: oshimat@kcch.jp
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Abstract

Background/Aim: Stanniocalcin2 (STC2) is associated with proliferation, invasion, and metastasis in various cancers. We examined the clinical significance of STC2 mRNA expression in patients with colorectal cancer (CRC). Patients and Methods: Relative expression levels of STC2 mRNA in CRC tissues and corresponding normal mucosa obtained from 202 patients were measured using quantitative real-time reverse transcriptase-polymerase chain reaction. Results: Expression of STC2 mRNA was higher in the cancer tissue than in the adjacent normal mucosa. STC2 mRNA expression in cancer tissues was associated with tumour size, liver metastasis, venous invasion, and lymph node metastasis. High expression of STC2 mRNA was significantly associated with poorer postoperative survival (p=0.0003). Multivariate analysis showed that high expression of STC2 mRNA was an independent predictor of postoperative survival. Conclusion: High expression of STC2 mRNA in CRC tissue may be a useful prognostic marker in patients with CRC.

Key Words:
  • Stanniocalcin2
  • colorectal cancer
  • prognostic factor
  • Received February 11, 2021.
  • Revision received February 20, 2021.
  • Accepted February 22, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Clinical Significance of Stanniocalcin2 mRNA Expression in Patients With Colorectal Cancer
TAKUO WATANABE, MANABU SHIOZAWA, YAYOI KIMURA, YUKIHIKO HIROSHIMA, ITARU HASHIMOTO, KEISUKE KOMORI, HAYATO WATANABE, KAZUKI KANO, HIROHITO FUJIKAWA, TORU AOYAMA, MASAKATSU NUMATA, TAKANOBU YAMADA, HIROSHI TAMAGAWA, TAKASHI OGATA, NORIO YUKAWA, SOICHIRO MORINAGA, YASUSHI RINO, MUNETAKA MASUDA, YOHEI MIYAGI, TAKASHI OSHIMA
Anticancer Research Apr 2021, 41 (4) 2117-2122; DOI: 10.21873/anticanres.14983

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Clinical Significance of Stanniocalcin2 mRNA Expression in Patients With Colorectal Cancer
TAKUO WATANABE, MANABU SHIOZAWA, YAYOI KIMURA, YUKIHIKO HIROSHIMA, ITARU HASHIMOTO, KEISUKE KOMORI, HAYATO WATANABE, KAZUKI KANO, HIROHITO FUJIKAWA, TORU AOYAMA, MASAKATSU NUMATA, TAKANOBU YAMADA, HIROSHI TAMAGAWA, TAKASHI OGATA, NORIO YUKAWA, SOICHIRO MORINAGA, YASUSHI RINO, MUNETAKA MASUDA, YOHEI MIYAGI, TAKASHI OSHIMA
Anticancer Research Apr 2021, 41 (4) 2117-2122; DOI: 10.21873/anticanres.14983
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Keywords

  • Stanniocalcin2
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