Impact of Renin–angiotensin System Inhibitors on the Efficacy of Anti-PD-1/PD-L1 Antibodies in NSCLC Patients

TAKEHIRO TOZUKA; NORIKO YANAGITANI; HIROSHI YOSHIDA; RYO MANABE; SHINSUKE OGUSU; RYOSUKE TSUGITOMI; HIROAKI SAKAMOTO; YOSHIAKI AMINO; RYO ARIYASU; KEN UCHIBORI; SATORU KITAZONO; MASAHIRO SEIKE; AKIHIKO GEMMA; MAKOTO NISHIO

doi:10.21873/anticanres.14980

Research ArticleClinical Studies

Impact of Renin–angiotensin System Inhibitors on the Efficacy of Anti-PD-1/PD-L1 Antibodies in NSCLC Patients

TAKEHIRO TOZUKA, NORIKO YANAGITANI, HIROSHI YOSHIDA, RYO MANABE, SHINSUKE OGUSU, RYOSUKE TSUGITOMI, HIROAKI SAKAMOTO, YOSHIAKI AMINO, RYO ARIYASU, KEN UCHIBORI, SATORU KITAZONO, MASAHIRO SEIKE, AKIHIKO GEMMA and MAKOTO NISHIO

Anticancer Research April 2021, 41 (4) 2093-2100; DOI: https://doi.org/10.21873/anticanres.14980

TAKEHIRO TOZUKA

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

2Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan

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NORIKO YANAGITANI

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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HIROSHI YOSHIDA

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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RYO MANABE

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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SHINSUKE OGUSU

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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RYOSUKE TSUGITOMI

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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HIROAKI SAKAMOTO

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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YOSHIAKI AMINO

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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RYO ARIYASU

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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KEN UCHIBORI

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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SATORU KITAZONO

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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MASAHIRO SEIKE

2Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan

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AKIHIKO GEMMA

2Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan

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MAKOTO NISHIO

1Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;

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For correspondence: mnishio@jfcr.or.jp

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Article Information

vol. 41 no. 4 2093-2100

DOI

https://doi.org/10.21873/anticanres.14980

PubMed

33813419

Published By

International Institute of Anticancer Research

Print ISSN

0250-7005

Online ISSN

1791-7530

History

Received February 9, 2021
Revision received February 18, 2021
Accepted February 19, 2021
Published online April 3, 2021.

Author Information

TAKEHIRO TOZUKA¹,²,
NORIKO YANAGITANI¹,
HIROSHI YOSHIDA¹,
RYO MANABE¹,
SHINSUKE OGUSU¹,
RYOSUKE TSUGITOMI¹,
HIROAKI SAKAMOTO¹,
YOSHIAKI AMINO¹,
RYO ARIYASU¹,
KEN UCHIBORI¹,
SATORU KITAZONO¹,
MASAHIRO SEIKE²,
AKIHIKO GEMMA² and
MAKOTO NISHIO¹ ⇑

¹Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;
²Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan

Correspondence to: Dr. Makoto Nishio, Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan. Tel: +81 335200111, Fax: +81 335700343, e-mail: mnishio{at}jfcr.or.jp

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