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Research ArticleClinical Studies

Prognostic Role for CYFRA 21-1 in Patients With Advanced-stage NSCLC Treated With Bevacizumab Plus Chemotherapy

MARTIN SVATON, JIRI BLAZEK, GABRIELA KRAKOROVA, MILOS PESEK, MARCELA BURESOVA, ZUZANA TEUFELOVA, JOSEF VODICKA, KAROLINA HURDALKOVA, MAGDA BARINOVA and ONDREJ TOPOLCAN
Anticancer Research April 2021, 41 (4) 2053-2058; DOI: https://doi.org/10.21873/anticanres.14974
MARTIN SVATON
1Department of Pneumology and Phthisiology, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic;
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  • For correspondence: svatonm@fnplzen.cz
JIRI BLAZEK
1Department of Pneumology and Phthisiology, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic;
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GABRIELA KRAKOROVA
1Department of Pneumology and Phthisiology, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic;
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MILOS PESEK
1Department of Pneumology and Phthisiology, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic;
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MARCELA BURESOVA
1Department of Pneumology and Phthisiology, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic;
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ZUZANA TEUFELOVA
1Department of Pneumology and Phthisiology, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic;
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JOSEF VODICKA
2Department of Surgery, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic;
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KAROLINA HURDALKOVA
3Institute of Biostatistics and Analyses, Ltd., Brno, Czech Republic;
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MAGDA BARINOVA
3Institute of Biostatistics and Analyses, Ltd., Brno, Czech Republic;
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ONDREJ TOPOLCAN
4Department of Nuclear Medicine, Charles University, Faculty of Medicine in Pilsen, Pilsen, Czech Republic
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Abstract

Aim: To investigate potential associations between selected oncomarkers [carcinoembryonic antigen (CEA), C-terminus of cytokeratin 19 (CYFRA 21-1, CYFRA), and squamous cell carcinoma antigen (SCC)] and outcomes in patients with NSCLC treated with bevacizumab plus chemotherapy. Patients and Methods: We retrospectively analysed 105 patients with NSCLC from the Czech TULUNG registry treated at University Hospital in Pilsen with bevacizumab plus chemotherapy. Response to therapy was tested by Fisher’s exact test. Survival statistics were evaluated using the Kaplan–Meier method and Cox analysis. Results: Only normal values of CYFRA (not CEA or SCC) were associated with significantly better overall and progression-free survival in univariate analysis. We also observed a trend for a better disease control rate in patients with normal levels of CYFRA. In a multivariate Cox model, only CYFRA was associated with significantly better overall but not progression-free survival. Conclusion: In our retrospective study, we point out the possibility of using CYFRA as a prognostic marker in patients with NSCLC treated with chemotherapy plus bevacizumab.

Key Words:
  • Bevacizumab
  • CEA
  • CYFRA
  • SCC
  • NSCLC
  • predictive
  • prognostic
  • Received January 30, 2021.
  • Revision received February 17, 2021.
  • Accepted February 18, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (4)
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Prognostic Role for CYFRA 21-1 in Patients With Advanced-stage NSCLC Treated With Bevacizumab Plus Chemotherapy
MARTIN SVATON, JIRI BLAZEK, GABRIELA KRAKOROVA, MILOS PESEK, MARCELA BURESOVA, ZUZANA TEUFELOVA, JOSEF VODICKA, KAROLINA HURDALKOVA, MAGDA BARINOVA, ONDREJ TOPOLCAN
Anticancer Research Apr 2021, 41 (4) 2053-2058; DOI: 10.21873/anticanres.14974

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Prognostic Role for CYFRA 21-1 in Patients With Advanced-stage NSCLC Treated With Bevacizumab Plus Chemotherapy
MARTIN SVATON, JIRI BLAZEK, GABRIELA KRAKOROVA, MILOS PESEK, MARCELA BURESOVA, ZUZANA TEUFELOVA, JOSEF VODICKA, KAROLINA HURDALKOVA, MAGDA BARINOVA, ONDREJ TOPOLCAN
Anticancer Research Apr 2021, 41 (4) 2053-2058; DOI: 10.21873/anticanres.14974
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Keywords

  • bevacizumab
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