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Research ArticleClinical Studies

Value of Panendoscopy in the Identification of Synchronous Malignancies in Patients Suffering from Oral Squamous Cell Carcinoma Without Clinical Signs of a Second Primary Tumor

STEFFEN KOERDT, JAN-DIRK RAGUSE, FELIX NEUMANN, BENEDICTA BECK-BROICHSITTER, KILIAN KREUTZER, KONRAD NEUMANN, MAX HEILAND and CHRISTIAN DOLL
Anticancer Research April 2021, 41 (4) 2039-2044; DOI: https://doi.org/10.21873/anticanres.14972
STEFFEN KOERDT
1Department of Oral and Maxillofacial Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany;
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  • For correspondence: steffen.koerdt@charite.de
JAN-DIRK RAGUSE
2Department of Oral and Maxillofacial Surgery, Fachklinik Hornheide, Münster, Germany;
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FELIX NEUMANN
1Department of Oral and Maxillofacial Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany;
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BENEDICTA BECK-BROICHSITTER
1Department of Oral and Maxillofacial Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany;
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KILIAN KREUTZER
1Department of Oral and Maxillofacial Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany;
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KONRAD NEUMANN
3Department for Biostatistics and Clinical Epidemiology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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MAX HEILAND
1Department of Oral and Maxillofacial Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany;
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CHRISTIAN DOLL
1Department of Oral and Maxillofacial Surgery, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany;
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Abstract

Background/Aim: The aim of the present study was to assess the value of panendoscopy of the upper aero-digestive tract in the identification of synchronous tumors in OSCC patients without clinical signs of a second primary tumor. Patients and Methods: In this retrospective study, patients diagnosed with a primary OSCC who received surgical therapy between January 1st, 2012 and December 31st, 2017 were included. Participants must have undergone panendoscopy during the staging process. None of these patients showed clinical signs of a second primary tumor. Results: A total of 265 patients (99 females and 166 males; mean age=63.3 years, range=26-96 years) were included. The mean (SD) follow-up was 25.88 (±20.479 SD) months. Five synchronous secondary tumors (1.9%) could be identified within this cohort. Of these, only two (0.8%) were located within the area of panendoscopy and were diagnosed in patients with regular alcohol and/or tobacco abuse. Eighteen metachronous second primary tumors were diagnosed, 10 being located within the upper aero-digestive tract. Conclusion: The relevance of routinely performed panendoscopy in patients suffering from an oral squamous cell carcinoma without clinical signs of a secondary tumor should be critically re-evaluated, especially in patients without typical risk factors.

Key Words:
  • Panendoscopy
  • oral squamous cell carcinoma
  • head and neck cancer
  • synchronous malignancy
  • staging
  • Received January 18, 2021.
  • Revision received February 24, 2021.
  • Accepted February 25, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (4)
Anticancer Research
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Value of Panendoscopy in the Identification of Synchronous Malignancies in Patients Suffering from Oral Squamous Cell Carcinoma Without Clinical Signs of a Second Primary Tumor
STEFFEN KOERDT, JAN-DIRK RAGUSE, FELIX NEUMANN, BENEDICTA BECK-BROICHSITTER, KILIAN KREUTZER, KONRAD NEUMANN, MAX HEILAND, CHRISTIAN DOLL
Anticancer Research Apr 2021, 41 (4) 2039-2044; DOI: 10.21873/anticanres.14972

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Value of Panendoscopy in the Identification of Synchronous Malignancies in Patients Suffering from Oral Squamous Cell Carcinoma Without Clinical Signs of a Second Primary Tumor
STEFFEN KOERDT, JAN-DIRK RAGUSE, FELIX NEUMANN, BENEDICTA BECK-BROICHSITTER, KILIAN KREUTZER, KONRAD NEUMANN, MAX HEILAND, CHRISTIAN DOLL
Anticancer Research Apr 2021, 41 (4) 2039-2044; DOI: 10.21873/anticanres.14972
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Keywords

  • Panendoscopy
  • oral squamous cell carcinoma
  • head and neck cancer
  • synchronous malignancy
  • staging
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