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Research ArticleExperimental Studies

Nardostachys jatamansi Root Extract Attenuates Tumor Progression in Hepatocellular Carcinoma via Inhibition of ERK/STAT3 Pathways

GIL WON LEE, WONHEE HUR, JUNG-HEE KIM, DONG JUN PARK, SUNG MIM KIM, BYUNG-YOON KANG, PIL SOO SUNG and SEUNG KEW YOON
Anticancer Research April 2021, 41 (4) 1883-1893; DOI: https://doi.org/10.21873/anticanres.14954
GIL WON LEE
1The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
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WONHEE HUR
1The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
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JUNG-HEE KIM
1The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
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DONG JUN PARK
1The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
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SUNG MIM KIM
1The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
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BYUNG-YOON KANG
1The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
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PIL SOO SUNG
1The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
2Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
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SEUNG KEW YOON
1The Catholic University Liver Research Center, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
2Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
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  • For correspondence: yoonsk@catholic.ac.kr
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Abstract

Background/Aim: Hepatocellular carcinoma (HCC) is a highly prevalent disease and treatment is limited. Therefore, development of new therapeutic agents is urgent. The aim of this study was to investigate the in vitro and in vivo anti-cancer effects of Nardostachys jatamansi root extract (NJRE) against HCC and underlying mechanisms involved in such effects. Materials and Methods: Effects of NJRE on viability of HCC cell lines were determined by MTT analysis and annexin/PI apoptosis assays. Expression levels of proteins in MAPK and STAT3 pathways and caspase-3 and PARP after treatment with NJRE in HCC cell lines were determined by western blotting. In a syngeneic model using mouse HCC cells Hepa1-6, inhibition of tumor formation after oral administration of NJRE was determined and expression levels of phospho-ERK and phospho-STAT3 in liver tissues were analyzed by immunohistochemical staining. Results: NJRE reduced the activation of STAT3 by inhibiting the expression of ERK and finally attenuated the proliferation of HCC. Conclusion: NJRE has anti-cancer effects against HCC. It has potential to be used in the treatment of human HCC.

Key Words:
  • Hepatocellular carcinoma
  • anti-cancer effect
  • Nardostachys jatamansi root extract
  • Received January 25, 2021.
  • Revision received February 26, 2021.
  • Accepted March 1, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (4)
Anticancer Research
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April 2021
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Nardostachys jatamansi Root Extract Attenuates Tumor Progression in Hepatocellular Carcinoma via Inhibition of ERK/STAT3 Pathways
GIL WON LEE, WONHEE HUR, JUNG-HEE KIM, DONG JUN PARK, SUNG MIM KIM, BYUNG-YOON KANG, PIL SOO SUNG, SEUNG KEW YOON
Anticancer Research Apr 2021, 41 (4) 1883-1893; DOI: 10.21873/anticanres.14954

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Nardostachys jatamansi Root Extract Attenuates Tumor Progression in Hepatocellular Carcinoma via Inhibition of ERK/STAT3 Pathways
GIL WON LEE, WONHEE HUR, JUNG-HEE KIM, DONG JUN PARK, SUNG MIM KIM, BYUNG-YOON KANG, PIL SOO SUNG, SEUNG KEW YOON
Anticancer Research Apr 2021, 41 (4) 1883-1893; DOI: 10.21873/anticanres.14954
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