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Research ArticleExperimental Studies

Serum Proteomic Profiling Reveals Differentially Expressed IGHG3 and A1AG1 as Potential Predictors of Chemotherapeutic Response in Advanced Non-small Cell Lung Cancer

MAY MYAT MON, CHANTRAGAN SRISOMSAP, DARANEE CHOKCHAICHAMNANKIT, KAMOLWAN WATCHARATANYATIP, CHURAT WEERAPHAN, JISNUSON SVASTI, KAJORNKIAT MANEECHAI, PARAMEE THONGSUKSAI and PRITSANA RAUNGRUT
Anticancer Research April 2021, 41 (4) 1871-1882; DOI: https://doi.org/10.21873/anticanres.14953
MAY MYAT MON
1Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand;
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CHANTRAGAN SRISOMSAP
2Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand;
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DARANEE CHOKCHAICHAMNANKIT
2Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand;
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KAMOLWAN WATCHARATANYATIP
2Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand;
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CHURAT WEERAPHAN
2Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand;
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JISNUSON SVASTI
2Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand;
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KAJORNKIAT MANEECHAI
3Department of Biology, Faculty of Sciences, Prince of Songkla University, Songkhla, Thailand;
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PARAMEE THONGSUKSAI
4Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
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PRITSANA RAUNGRUT
1Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand;
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  • For correspondence: rpritsan@medicine.psu.ac.th
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Abstract

Background: This study aimed to identify differentially expressed proteins in the serum of advanced non-small cell lung cancer (NSCLC) patients responding to carboplatin (CAR) plus paclitaxel (PTX) chemotherapy compared to non-responders. Materials and Methods: Serum from 8 responders and 6 non-responders was subjected to proteomic analysis by label-free liquid chromatography tandem mass spectrometry and validated by western blotting. CAR/PTX-resistant human H1792 and A549 cells were used for evaluating gene expression. Results: Fifty-two proteins were differentially expressed between responders and non-responders. Alpha 1 antitrypsin antibody, alpha 1 acid glycoprotein (A1AG1), afamin, protein S100-A9 and immunoglobulin heavy constant gamma 3 (IGHG3) were validated. IGHG3 was elevated (p=0.037) while A1AG1 was reduced (p=0.003) in responders as compared to non-responders. Gene expression of IGHG3 and ORM1 in resistant cells showed consistent results with the proteomics profiles. Conclusion: Serum expression levels of IGHG3 and A1AG1 proteins may be useful to recruit an NSCLC subpopulation that can benefit from CAR plus PTX standard therapy.

Key Words:
  • Serum
  • carboplatin
  • paclitaxel
  • proteomic
  • non-small cell lung cancer
  • Received January 25, 2021.
  • Revision received February 20, 2021.
  • Accepted February 22, 2021.
  • Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 41 (4)
Anticancer Research
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April 2021
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Serum Proteomic Profiling Reveals Differentially Expressed IGHG3 and A1AG1 as Potential Predictors of Chemotherapeutic Response in Advanced Non-small Cell Lung Cancer
MAY MYAT MON, CHANTRAGAN SRISOMSAP, DARANEE CHOKCHAICHAMNANKIT, KAMOLWAN WATCHARATANYATIP, CHURAT WEERAPHAN, JISNUSON SVASTI, KAJORNKIAT MANEECHAI, PARAMEE THONGSUKSAI, PRITSANA RAUNGRUT
Anticancer Research Apr 2021, 41 (4) 1871-1882; DOI: 10.21873/anticanres.14953

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Serum Proteomic Profiling Reveals Differentially Expressed IGHG3 and A1AG1 as Potential Predictors of Chemotherapeutic Response in Advanced Non-small Cell Lung Cancer
MAY MYAT MON, CHANTRAGAN SRISOMSAP, DARANEE CHOKCHAICHAMNANKIT, KAMOLWAN WATCHARATANYATIP, CHURAT WEERAPHAN, JISNUSON SVASTI, KAJORNKIAT MANEECHAI, PARAMEE THONGSUKSAI, PRITSANA RAUNGRUT
Anticancer Research Apr 2021, 41 (4) 1871-1882; DOI: 10.21873/anticanres.14953
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Keywords

  • Serum
  • carboplatin
  • paclitaxel
  • proteomic
  • non-small cell lung cancer
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